A Simple Synthetic Route for the Preparation of Tetramethylglycolide from Lactic Acid

• Watanabe, Kohtaro

• Ando, Yoshito

• Shirai, Yoshihito

• Nishida, Haruo

Abstract

Poly(tetramethylglycolide), a chemical recyclable polymer, is currently attracting a lot of interest as a substitute for poly(L-lactic acid). We report here a simple and convenient route for the synthesis of tetramethylglycolide (TMG) from lactic acid. This method involves three steps: (1) one-step protection of lactic acid by cyclic acetalization employing acetone; (2) α-methylation of the obtained 2,2,5-trimethyl-1,3-dioxolan-4-one; and (3) one-pot synthesis of TMG including the hydrolysis of 2,2,5,5-tetramethyl-1,3-dioxolan-4-one. We found significant advantages of the incorporation of existing reactions in the synthesis of TMG.

Journal

• Chemistry Letters

  Chemistry Letters 42 (2), 159-161, 2013-02-01

  公益社団法人日本化学会

Keywords

• General Chemistry

Details

• CRID: 1050564288865360896
• NII Article ID: 10031143831
• NII Book ID: AA00603318
• ISSN: 03667022
• ISSN: 13480715
• DOI: 10.1246/cl.2013.159
• HANDLE: 10228/00006648
• Web Site: https://kyutech.repo.nii.ac.jp/records/5437
• Web Site: https://academic.oup.com/chemlett/article-pdf/42/2/159/55637223/cl.2013.159.pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN