Inhibition of Cell Motility by Fucoidan Derived from <I>Cladosiphon Okamuranus</I>

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  • Yamasaki Yumi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University Department of Biochemistry and Applied Bioscience, Faculty of Agriculture, University of Miyazaki
  • Ando Yoshiko
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • Yamasaki Masao
    Department of Biochemistry and Applied Bioscience, Faculty of Agriculture, University of Miyazaki
  • Tachibana Hirofumi
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
  • Yamada Koji
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University

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Other Title
  • オキナワモズク由来フコイダンの細胞運動阻害作用
  • オキナワモズク ユライ フコイダン ノ サイボウ ウンドウ ソガイ サヨウ
  • Inhibition of Cell Motility by Fucoidan Derived from Cladosiphon Okamuranus

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Abstract

Fucoidan is an active component of seaweed that has been shown to exhibit a number of biological regulation effects, such as inhibition of proliferation and induction of apoptosis, in various tumor cells. In this study, we demonstrated that fucoidan isolated from Cladosiphon okamuranus significantly inhibited cell motility in several cancer cells in a dose-dependent manner. Fucoidan induced the disruption of stress fibers at concentrations greater than 10μg/mL. However, fucoidan was not shown to decrease the phosphorylation of the myosin II regulatory light chain (MRLC) at Thr18/Ser19 in B16 cells. These data suggested that the inhibition of cell motility by treatment with fucoidan was induced via a pathway other than MRLC.

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