Apple Polyphenol Improves Lipid Metabolism and Insulin Independence in Obese Rats

• Ohta Yutaka

  Fundamental Research Laboratory, Asahi Breweries, Ltd.

• Funayama Makoto

  Faculty of Agriculture and Life Science, Hirosaki University

• Seino Hirotake

  Faculty of Agriculture and Life Science, Hirosaki University

• Sami Manabu

  Fundamental Research Laboratory, Asahi Breweries, Ltd.

• Kanda Tomomasa

  Fundamental Research Laboratory, Asahi Breweries, Ltd.

• Shoji Toshihiko

  Fundamental Research Laboratory, Asahi Breweries, Ltd.

• Ohtake Yasuyuki

  Fundamental Research Laboratory, Asahi Breweries, Ltd.

• Osada Kyoichi

  Faculty of Agriculture and Life Science, Hirosaki University

Bibliographic Information

Other Title

• リンゴポリフェノールによる易肥満性ラットの脂質代謝およびインスリン非依存性の改善
• リンゴ ポリフェノール ニ ヨル イヒマンセイ ラット ノ シシツ タイシャ オヨビ インスリン ヒイソンセイ ノ カイゼン

Abstract

We evaluated the effects of apple polyphenol (AP), of which the major components are procyanidins, on obesity and glucose tolerance using Zucker fatty rats (fa/fa). In this study, Zucker fatty rats were fed diets containing 0.2% or 1.0% apple polyphenol for 12 weeks. Visceral fat weight and triglyceride levels in blood and liver were reduced by AP intake. Glucose and insulin levels in blood also decreased, and the amount of fatty acids excreted into feces increased in dose-dependent manner. Furthermore, suppression of fatty acid synthase gene expression in the liver and increase of adiponectin gene expression in white adipose tissues were observed. These results indicate that AP improves lipid metabolism and insulin resistance.

Journal

• Nippon Shokuhin Kagaku Kogaku Kaishi

  Nippon Shokuhin Kagaku Kogaku Kaishi 54 (6), 287-294, 2007

  Japanese Society for Food Science and Technology

Keywords

• apple
• procyanidins
• obesity
• Zucker fatty rat
• insulin resistance

Details

• CRID: 1390282681384787200
• NII Article ID: 130000051520
• NII Book ID: AN10467499
• DOI: 10.3136/nskkk.54.287
• COI: 1:CAS:528:DC%2BD2sXnsFemu7o%3D
• ISSN: 18816681
• ISSN: 1341027X
• NDL BIB ID: 8762854
• Web Site: http://id.ndl.go.jp/bib/8762854
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8762854
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed