Neural oscillatory dynamics in psychiatry

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  • Onitsuka Toshiaki
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University
  • PJ Uhlhaas
    Institute of Neuroscience and Psychology, University of Glasgow.
  • Tada Mariko
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo
  • KM Spencer
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School
  • Hirano Yoji
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School
  • RW McCarley
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School

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Other Title
  • 精神科領域における Neural Oscillation 研究
  • セイシンカ リョウイキ ニ オケル Neural Oscillation ケンキュウ

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Abstract

In patients with schizophrenia, the synchronisation of beta- and gamma- band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and symptoms of the disorder. Dysfunctional oscillations may arise due to anomalies in the brainʼs rhythm generating networks of γ- aminobutyric acid (GABA) interneurons and deficits in NMDA - receptor functioning. In this symposium, McCarley et al. described findings on optogenetic studies in mice and MRS studies in the schizophrenia spectrum. Uhlhaas et al. presented perspectives for high gamma - band oscillations in schizophrenia and ketamine - induced psychosis in MEG. Tada et al. reported results of electroencephalographic auditory steady state responses (ASSR) in subjects at ultra - high risk and first - episode schizophrenia. Finally, Onitsuka et al. showed MEG - ASSR in patients with schizophrenia and bipolar disorder. Neural oscillations are possible translational paradigms, since they can be recorded from animals, healthy subjects and clinical groups.

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