An attempt of behavioral analysis of model mice for schizophrenia

• Sasaoka Toshikuni

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Sato Asako

  Department of Laboratory Animal Science, Kitasato University School of Medicine

• Nakamura Toru

  Graduate School of Frontier Biosciences, Osaka University

• Okubo Tadashi

  Department of Laboratory Animal Science, Kitasato University School of Medicine

• Sato Toshiya

  Department of Laboratory Animal Science, Kitasato University School of Medicine

• Fujisama Nobuyoshi

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Maeda Yoshitaka

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Oda Kanako

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Sakai Seiko

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Jimbo Yukihiro

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Umakawa Eriko

  Department of Comparative and Experimental Medicine, Brain Research Institute Niigata University

• Kitsukawa Takashi

  Graduate School of Frontier Biosciences, Osaka University

• Momiyama Toshihiko

  Department of Pharmacology, Jikei University School of Medicine

• Yamamori Tetsuo

  RIKEN Brain Science Institute

Bibliographic Information

Other Title

• 統合失調症モデルマウスの行動解析方法の試み
• トウゴウ シッチョウショウ モデルマウス ノ コウドウ カイセキ ホウホウ ノ ココロミ

Abstract

An approach of behavioral pharmacologic methods using animal models greatly contributed to the progress of understanding of symptoms of schizophrenia, evaluation of animal models of schizophrenia and development of therapeutic agents. Although genetically modified mice provide indispensable information for understanding the functions of target genes, studies on behavioral alteration of genetically modified mice showed inconsistent results. In this study, we used congenic dopamine D1 and D2 receptor knockout (D1R KO, D2R KO) mice and compared them simultaneously under the same conditions. We monitored their motor activity in their home cages continuously for five days as normal spontaneous activity, in which the effects of external factors are negligible. For better understanding of characteristics of motor activity, we measured the intensity of activity and the duration and number of active and inactive bouts by examining the data of the motor activity in the home cage. In addition we measured the volume of food and water intake while monitoring the motor activity. In monitoring spontaneous motor activities, D1R and D2R KO mice showed higher and lower 24 h activities, respectively, than wild type mice. We consider this novel analytical methods can be applied to analysis of behavioral alteration of animal models of schizophrenia.

Journal

• Japanese Journal of Biological Psychiatry

  Japanese Journal of Biological Psychiatry 26 (2), 87-94, 2015

  Japanese Society of Biological Psychiatry

Keywords

• a mouse model
• schizophrenia
• validity
• spontaneous activity
• behavior

Details

• CRID: 1390001205412792576
• NII Article ID: 130005395590
• NII Article ID: 40020552375
• NII Book ID: AA12468060
• DOI: 10.11249/jsbpjjpp.26.2_87
• ISSN: 21866465
• ISSN: 21866619
• NDL BIB ID: 026645520
• Web Site: http://id.ndl.go.jp/bib/026645520
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026645520
• Web Site: https://search.jamas.or.jp/link/ui/2015340194
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed