-
- Tamura Hideki
- Life Science Tokyo Advanced Research Center(L-StaR), Hoshi University
Bibliographic Information
- Other Title
-
- ニューロプシンによる統合失調症脆弱因子 Neuregulin-1のプロセシングを介した抑制性ニューロンの制御機構
- ニューロプシンによる統合失調症脆弱因子Neuregulin─1のプロセシングを介した抑制性ニューロンの制御機構
- ニューロプシン ニ ヨル トウゴウ シッチョウショウ ゼイジャク インシ Neuregulin ─ 1 ノ プロセシング オ カイシタ ヨクセイセイ ニューロン ノ セイギョ キコウ
Search this article
Abstract
Neuronal inhibition is essential for cognitive processes in the brain, but molecular mechanisms mediating activity - dependent regulation of inhibitory GABAergic interneurons remain unclear. Neuropsin proteolytically cleaved mature neuregulin 1 (NRG1) bound to extracellular glycosaminoglycans, liberating the soluble ligand, which activated its receptor, ErbB4. Processed NRG1 was directed to ErbB4 - and parvalbumin - expressing interneurons and subsequently activated GABAergic transmission. Neuropsin- knockout mice exhibited disruption of the excitation- inhibition balance (E/I balance) and impairments in long- term potentiation, both of which are essential in processing and storing information, reversed by application of the NRG1 ligand moiety. These results suggest that neuropsin regulates GABAergic interneurons through NRG1 - ErbB4 signaling during network activity and reveal mechanisms linking neuropsin/NRG1/ErbB4 signaling with network balance control that may be altered in patients with schizophrenia.
Journal
-
- Japanese Journal of Biological Psychiatry
-
Japanese Journal of Biological Psychiatry 26 (4), 187-191, 2015
Japanese Society of Biological Psychiatry
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205412805120
-
- NII Article ID
- 130005395619
-
- NII Book ID
- AA12468060
-
- ISSN
- 21866465
- 21866619
-
- NDL BIB ID
- 027102836
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed