Studies on a short-term bioassay of toxic chemicals using Saccharomyces cerevisiae Saccharomyces cerevisiaeを用いた有害化学物質の短期間生物試験に関する研究

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著者

    • Athanassios Kungolos アタナシオス クンゴロス

書誌事項

タイトル

Studies on a short-term bioassay of toxic chemicals using Saccharomyces cerevisiae

タイトル別名

Saccharomyces cerevisiaeを用いた有害化学物質の短期間生物試験に関する研究

著者名

Athanassios Kungolos

著者別名

アタナシオス クンゴロス

学位授与大学

岡山大学

取得学位

学術博士

学位授与番号

甲第1027号

学位授与年月日

1992-03-28

注記・抄録

博士論文

目次

  1. CONTENTS / p1 (0003.jp2)
  2. SUMMARY / p5 (0007.jp2)
  3. A.INTRODUCTION / p9 (0011.jp2)
  4. A.1.Purpose of the study. / p9 (0011.jp2)
  5. A.2.Toxicity tests in general. / p11 (0013.jp2)
  6. A.3.Mutagenicity tests (Ames test, Rec assay etc.) / p11 (0013.jp2)
  7. A.4.Earlier use of Saccharomyces cerevisiae in toxicity testing. / p14 (0016.jp2)
  8. A.5.Advantages and disadvantages of S.cerevisiae as a test organism. / p14 (0016.jp2)
  9. B.MATERIALS AND METHODS / p16 (0018.jp2)
  10. B.1.Culture of S.cerevisiae. / p16 (0018.jp2)
  11. B.2.Different strains of S.cerevisiae. / p17 (0019.jp2)
  12. B.3.Bioscreen-C analyzer system. / p19 (0021.jp2)
  13. B.4.Relationship between light absorbance and cell density. / p22 (0024.jp2)
  14. B.5.Mathematical model for dose-response. / p24 (0026.jp2)
  15. B.6.Methods used for the evaluation of the interactive effect of chemicals. / p25 (0027.jp2)
  16. B.7.Statistical analysis of the results. / p27 (0029.jp2)
  17. C.ANALYSIS OF THE GROWTH OF S.CEREVISIAE IN THE PRESENCE OF CHEMICALS / p30 (0032.jp2)
  18. C.1.Indices used for toxicity testing. / p30 (0032.jp2)
  19. C.2.Survival rate of S.cerevisiae. / p32 (0034.jp2)
  20. C.3.Maximum specific growth rate. / p33 (0035.jp2)
  21. C.4.Area till a given point. / p36 (0038.jp2)
  22. C.5.Maximum absorbance and maximum cell density. / p37 (0039.jp2)
  23. C.6.Turning point of the growth curve. / p38 (0040.jp2)
  24. D.EFFECT OF VARIOUS FORMS OF MERCURY ON S.CEREVISIAE / p40 (0042.jp2)
  25. D.1.Effect of organic mercury. / p40 (0042.jp2)
  26. D.2.Effect of inorganic forms. / p41 (0043.jp2)
  27. D.3.Comparison between different kinds of strains. / p45 (0047.jp2)
  28. D.4.Bioaccumulation of Hg in the cells of S. cercvisiae. / p47 (0049.jp2)
  29. D.5.Relationship between bioaccumulation and toxicity. / p50 (0052.jp2)
  30. D.6.Effect of complexing and chelating agents on the toxicity of Hg to S.cerevisiae. / p53 (0055.jp2)
  31. E.EFFECTS OF VARIOUS HEAVY METALS ON S.CEREVISIAE / p56 (0058.jp2)
  32. E.1.Effect of cadmium and nickel. / p56 (0058.jp2)
  33. E.2.Comparison between trivalent and hexavalent chromium. / p58 (0060.jp2)
  34. E.3.Effects of zinc, lead and copper. / p59 (0061.jp2)
  35. E.4.Using EDTA in order to avoid the precipitation problem. / p61 (0063.jp2)
  36. F.INTERACTIVE EFFECTS OF CHEMICALS / p63 (0065.jp2)
  37. F.1.Suggesting a method for evaluating the interactive effect of the chemicals. / p63 (0065.jp2)
  38. F.2.Theoretical basis for the "independent events method". / p64 (0066.jp2)
  39. F.3.Interactive effect of two chemicals. / p65 (0067.jp2)
  40. F.4.Interactive effect of three chemicals. / p67 (0069.jp2)
  41. F.5.Interactive effect of more than three chemicals. / p69 (0071.jp2)
  42. F.6.Interactive effect between chromium and nickel. / p70 (0072.jp2)
  43. F.7.Interactive effect between nickel and cadmium. / p72 (0074.jp2)
  44. F.8.Interactive effect between cadmium and chromium. / p74 (0076.jp2)
  45. F.9.Interactive effect between chromium, cadmium and nickel. / p75 (0077.jp2)
  46. G.EFFECTS OF ORGANIC CHEMICALS ON S.CEREVISIAE / p80 (0082.jp2)
  47. G.1.Ethyl alcohol as a solvent. / p80 (0082.jp2)
  48. G.2.DMSO and acetone as solvents. / p82 (0084.jp2)
  49. G.3.Effect of monochlorophenols. / p84 (0086.jp2)
  50. G.4.Effect of dichlorophenols. / p87 (0089.jp2)
  51. G.5.Effect of trichlorophenols. / p89 (0091.jp2)
  52. G.6.Effect of tetrachlorophenol. / p91 (0093.jp2)
  53. G.7.Effect of pentachlorophenol. / p93 (0095.jp2)
  54. G.8.Interactive effect of chlorophenols. / p94 (0096.jp2)
  55. G.9.Rationale for using QSAR. / p95 (0097.jp2)
  56. G.10.QSAR's for the effect of chlorophenols on S.cerevisiae. / p97 (0099.jp2)
  57. H.TESTING DNA DAMAGE CAUSED BY CHEMICALS / p101 (0103.jp2)
  58. H.1.Principle of the method. / p101 (0103.jp2)
  59. H.2.Comparison with other short-term mutagenicity and DNA damage assays. / p102 (0104.jp2)
  60. H.3.The effect of 4NQO. / p104 (0106.jp2)
  61. H.4.The effect of kanamycin. / p107 (0109.jp2)
  62. H.5.DNA damage caused by chlorophenols. / p108 (0110.jp2)
  63. H.6.DNA damage caused by Hg. / p110 (0112.jp2)
  64. H.7.The effect of bromouracil. / p111 (0113.jp2)
  65. H.8.The effect of nicotinic acid. / p113 (0115.jp2)
  66. I.CONCLUSIONS / p115 (0117.jp2)
  67. I.1.Evaluation of the method when used for toxieity assessment. / p115 (0117.jp2)
  68. I.2.Evaluation of the method when used for testing DNA damage. / p116 (0118.jp2)
  69. I.3.Future expansion of this study. / p116 (0118.jp2)
  70. LITERATURE CITED / p118 (0120.jp2)
  71. ACKNOWLEDGEMENTS / p129 (0131.jp2)
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各種コード

  • NII論文ID(NAID)
    500000083862
  • NII著者ID(NRID)
    • 8000000084072
  • DOI(NDL)
  • 本文言語コード
    • jpn
  • NDL書誌ID
    • 000000248176
  • データ提供元
    • 機関リポジトリ
    • NDL ONLINE
    • NDLデジタルコレクション

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