Application of chiral cyclic diols to asymmetric induction キラル環状ジオールを用いた不斉誘起反応
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著者
書誌事項
- タイトル
-
Application of chiral cyclic diols to asymmetric induction
- タイトル別名
-
キラル環状ジオールを用いた不斉誘起反応
- 著者名
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加藤, 恵介
- 著者別名
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カトウ, ケイスケ
- 学位授与大学
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九州大学
- 取得学位
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博士 (薬学)
- 学位授与番号
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甲第3298号
- 学位授与年月日
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1994-03-25
注記・抄録
博士論文
CHAPTER 1 Asymmetric alkylation of chiral acetals prepared from cyclic or acyclic β-keto esters and chiral cyclic diols CHAPTER 2 Preparation of optically active tricyclic 1,4-dioxepin-5-one derivatives and its application to asymmetric alkylation CHAPTER 3 Asymmetric induction to meso-cyclohexane-1,2-diol, based on diastereoselective elimination CHAPTER 4 Asymmetric oxidation of β-keto esters using chiral cyclic diols CHAPTER 5 A new type of asymmetric double Michael reaction induced by chiral acetal
目次
- CONTENTS / (0003.jp2)
- INTRODUCTION / p1 (0004.jp2)
- LIST OF PUBLICATIONS / p7 (0007.jp2)
- CHAPTER I Asymmetric alkylation of chiral acetals prepared from cyclic or acyclic β-keto esters and chiral cyclic diols / p9 (0008.jp2)
- 1.Introduction / p9 (0008.jp2)
- 2.Preparation of acetal substrates / p10 (0008.jp2)
- 3.Alkylation of five-membered ring and acyclic substrates / p12 (0009.jp2)
- 4.Alkylation of six-membered ring substrates / p14 (0010.jp2)
- 5.Determination of absolute configuration and proposed mechanism / p19 (0013.jp2)
- 6.Stereoselective synthesis of (+) and(-)-spiro [4.4] nonan-1,6-diols / p21 (0014.jp2)
- CHAPTER II Preparation of optically active tricyclic 1,4-dioxepin-5-one derivatives and its application to asymmetric alkylation / p32 (0019.jp2)
- 1.Introduction / p32 (0019.jp2)
- 2.Preparation of chiral tricyclic γ-oxa-α,β-unsaturated lactones / p34 (0020.jp2)
- 3.Asymmetric alkylation of chiral tricyclic γ-oxa-α,β-unsaturated lactones / p36 (0021.jp2)
- 4.Determination of absolute configuration and proposed mechanism / p38 (0022.jp2)
- CHAPTER III Asymmetric induction to meso-cyclohexane-1,2-diol, based on diastereoselective elimination / p42 (0024.jp2)
- 1.Introduction / p42 (0024.jp2)
- 2.Preparation of substrates / p43 (0025.jp2)
- 3.Asymmetric induction to meso-cyclohexane-1,2-diol / p45 (0026.jp2)
- 4.Determination of absolute configuration and proposed mechanism / p47 (0027.jp2)
- CHAPTER IV Asymmetric oxidation of β-keto esters using chiral cyclic diols / p51 (0029.jp2)
- 1.Introduction / p51 (0029.jp2)
- 2.Preparation of substrates / p52 (0029.jp2)
- 3.Oxidation of β'-trimethylsilyloxy enol ethers / p54 (0030.jp2)
- 4.Oxidation of enol ethers with free hydroxy group / p56 (0031.jp2)
- 5.Determination of absolute configuration and proposed mechanism / p58 (0032.jp2)
- CHAPTER V A new type of asymmetric double Michael reaction induced by chiral acetal / p64 (0035.jp2)
- 1.Introduction / p64 (0035.jp2)
- 2.Asymmetric double Michael reaction / p65 (0036.jp2)
- 3.Determination of absolute configuration and proposed mechanism / p69 (0038.jp2)
- SUMMARY OF THE ORIGINAL WORKS / p74 (0040.jp2)
- EXPERIMENTAL SECTION / p75 (0041.jp2)
- Chapter I / p75 (0041.jp2)
- Chapter II / p90 (0048.jp2)
- Chapter III / p94 (0050.jp2)
- Chapter IV / p97 (0052.jp2)
- Chapter V / p104 (0055.jp2)
- REFERENCES / p109 (0058.jp2)