Design and evaluation of novel functional nanoparticles as a DNA carrier 新規機能性ナノパーティクルの設計とそのDNA医薬担体としての評価

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Title: Design and evaluation of novel functional nanoparticles as a DNA carrier

博士論文

論文目録 / (0002.jp2)
Contents / (0004.jp2)
ChapterI General introduction / p1 (0008.jp2)
I-1 Gene Therapy / p1 (0008.jp2)
I-2 Various carriers for gene delivery in vivo / p5 (0012.jp2)
I-3 Biodegradable nanoparticles as a gene delivery carrier / p12 (0019.jp2)
I-4 Surface modificationof nanoparticles as a gene carrier / p14 (0021.jp2)
I-5 Objective in this study / p19 (0026.jp2)
Chapter II Preparation of nanoparticles bearing carbohydrate on their surfaces / p26 (0034.jp2)
II-1 Introduction / p26 (0034.jp2)
II-2 Experimental / p26 (0034.jp2)
II-3 Resultsand Discussion / p29 (0037.jp2)
II-4 Conclusion / p36 (0044.jp2)
Chapter III Preparation and characterization of nanoparticles consisting of PLL and PLA / p38 (0047.jp2)
III-1 Introduction / p38 (0047.jp2)
III-2 Experimental / p38 (0047.jp2)
III-3 Results and Discussion / p41 (0050.jp2)
III-4 Conclusion / p48 (0057.jp2)
Chapter IV Preparation and characterization of nanoparticles which have DNA retention site and recognition site on their surfaces / p50 (0060.jp2)
IV-1 Introduction / p50 (0060.jp2)
IV-2 Experimental / p50 (0060.jp2)
IV-3 Results and Discussion / p54 (0064.jp2)
IV-4 Conclusion / p80 (0090.jp2)
Chapter V Interaction of nanoparticles with biological components and cells / p83 (0094.jp2)
II-1 Introduction / p83 (0094.jp2)
II-2 Experimental / p83 (0094.jp2)
II-3 Results and Discussion / p86 (0097.jp2)
II-4 Conclusion / p99 (0110.jp2)
Chapter VI Conclusion / p101 (0113.jp2)
Abstract / (0006.jp2)

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