Molecular correlates of biological concepts
著者
書誌事項
Molecular correlates of biological concepts
（Comprehensive biochemistry, Section 6. Vol. 30-36 . A history of biochemistry ; vol. 34A）
Elsevier Science Publishers, 1986
- U.S.
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注記
Includes bibliographies and index
内容説明・目次
内容説明
This volume focuses on the prehistory to modern biochemistry. Three topics, representative of the protracted emergence of biochemistry as a molecular science, are presented: respiratory pigments, enzymes, and nucleic acids. Particular emphasis is placed on the first two of these topics. The story of the elucidation of protein structure, with emphasis placed on the link between scientific and intellectual history, is told, virtually for the first time at this level of sophistication.
目次
General Preface. Preface to Volume 34A. List of Plates. Part I. The Long, Long Way to Molecular Order. 1. Molecules and Macromolecules. 2. From Culture Broth to Primordial Soup. 3. Morphology of Molecules. 4. The Analogy Between Biomolecular Structure and Architecture. 5. The Animate and the Inanimate. Crystals and Life. 6. Complementarities Between Molecules. 7. Philosophical Undercurrents of the Resistance to the Notion of Biomolecules as Ordered Polymers. 8. Schizoid Tale of Two Schools. Part II. Proteins as Molecules. 9. The Name "Protein". 10. The Conceptualization of Albumins as a Class. 11. Crystallization of Proteins and the Molecular Weight of Hemoglobin. 12. Polypeptidic Nature of Proteins. 13. Dorothy Wrinch: the Mystique of Cyclol Theory, or the Story of a Mistaken Scientific Theory. 14. A Note on Two Wise Men. 15. Molecular Order in Proteins: the Contributions from Linus Pauling. 16. Sequence Analysis. 17. The Merrifield Automated Supported Peptide Synthesis. Part III. The Hemoglobin Story. 18. Historical Notes about Hemoglobin and its Various Names. 19. Cooperativity of Dioxygen Binding: the Bohr Effect. 20. Pauling and the Magnetic Properties of Hemoglobins. 21. Hemoglobin and the Beginnings of X-Ray Work on Proteins. 22. Determination of Phases in Single Crystals. 23. The X-Ray Structure of Sperm-Whale Myoglobin. 24. From the Myoglobin to the Hemoglobin Structure. 25. The Hemoglobin Structure and its Molecular Correlates for Biological Functions. 26. Molecular Disease: Sickle-Cell Hemoglobin. Part IV. Enzymes as Proteins. 27. Terminology: Ferment, Diastase, Enzyme. 28. Dissolution Operators. 29. Animal or Vegetable Origin of Ferments. 30. A Disquisition on an Unfavorable Zeitgeist. 31. Relation of Microorganisms to Fermentation and Putrefaction. 32. Ferments as Catalysts. 33. The Buchner Experiment. 34. The Aftermath of the Buchner Experiment. Crystallization of Enzymes. 35. Enzymes as Receptors Complementary to their Substrate. 36. Enzymatic Kinetics. 37. X-Ray Studies on Enzymes. Part V. Hemoglobin and Enzymes. 38. Tentative Sketch of a Comparative History. Subject Index. Name Index.
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