The design and analysis of clinical experiments
著者
書誌事項
The design and analysis of clinical experiments
（Wiley series in probability and mathematical statistics, . Applied probability and statistics）
Wiley, c1986
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注記
Includes bibliographies and indexes
内容説明・目次
内容説明
This reference book on clinical experimentation focuses on principles that are especially useful in the design and analysis of studies on human subjects. It shows how to choose between modern and classical competing designs for a clinical study - such as crossover designs, multicenter studies, and repeated measure experiments - how to carry out each design and analyze the resulting data. The book provides many practical examples, end-of-chapter problems and references, and solutions to each problem. The mathematical bases are given for several design strategies as well as for their analysis. Also provided are tables of critical values, 200 random permutations of the first one hundred integers, and an appendix on programmable methods for determining sample sizes.
目次
- Reliability of Measurement
- Simple Linear Regression Analysis
- The Parallel Groups Design
- Special Cases of the Parallel Groups Study
- Blocking to Control for Prognostic Variables
- Stratification to Control for Prognostic Variables
- Analysis of Covariance and the Study of Change
- Repeated Measurement Studies
- Latin and Greco-Latin Squares
- The Crossover Study
- Balanced Incomplete Block Designs
- Factorial Experiments
- Split-plot Designs and Confounding
- Appendix: Sample-size Determination.
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