Proteinase inhibitors
著者
書誌事項
Proteinase inhibitors
（Research monographs in cell and tissue physiology, v. 12）
Elsevier, 1986
大学図書館所蔵 件 / 全29件
-
該当する所蔵館はありません
- すべての絞り込み条件を解除する
注記
Includes bibliographical references and index
内容説明・目次
内容説明
The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
目次
Preface. List of Contributors. Section A. Introductory Chapters . 1. An introduction to the proteinases by A.J. Barrett. 2. The characterization of enzyme inhibition by C.G. Knight. Section B. Synthetic and Related Inhibitors . 3. Inhibitors of serine proteinases by J.C. Powers and J.W. Harper. 4. Inhibitors of cysteine proteinases by D.H. Rich. 5. Inhibitors of aspartic proteinases by D.H. Rich. 6. Inhibitors of metalloproteinases by J.C. Powers and J.W. Harper. Section C. Protein Inhibitors . 7. Introduction to the protein inhibitors: X-ray crystallography by R.J. Read and M.N.G. James. 8. Proteinase inhibitors of the leech hirudo medicinalis (hirudins, bdellins, eglins) by U. Seemuller et al. 9. Bowman-Birk family serine proteinase inhibitors by T. Ikenaka and S. Norioka. 10. Biochemistry of aprotinin and aprotinin-like inhibitors by W. Gebhard et al. 11. Inter-a-trypsin inhibitor and its close relatives by W. Gebhard and K. Hochstrasser. 12. Serpins: the superfamily of plasma serine proteinase inhibitors by R.W. Carrell and D.R. Boswell. 13. Molecular analysis of the serine proteinase inhibitor gene family by V.J. Kidd and S.L.C. Woo. 14. Human a 1 -proteinase inhibitor by H. Heidtmann and J. Travis. 15. a 2 -Antiplasmin by H.R. Lijnen and D. Collen. 16. Human C1-inhibitor by B. Wiman. 17. Antithrombina and related inhibitors of coagulation proteinases by I. Bjork and A. Danielsson. 18. Cysteine proteinase inhibitors of the cystatin superfamily by A.J. Barrett et al. 19. Calpastatins by C. Parkes. 20. Protein inhibitors of metallo-proteinases by T.E. Cawston. Section D. Biological Aspects . 21. Proteinase inhibitors as drugs by H.-P. Schnebli and N.J. Braun. Subject Index.
「Nielsen BookData」 より