The Retina : a model for cell biology studies

著者

• Adler, Ruben
• Farber, Debora

書誌事項

The Retina : a model for cell biology studies

edited by Ruben Adler, Debora Farber

（Cellular neurobiology）

Academic Press, 1986

• pt. 1
• pt. 2

注記

Includes bibliographies and indexes

内容説明・目次

巻冊次

pt. 1 ISBN 9780120442751

内容説明

The Retina: A Model for Cell Biology Studies, Part I, is the first of a two-part series that details developments in the study of retinal cell biology. The book begins with some basic information about retinal structure and development followed by a discussion of the advantages of the retina as a model system for cell biology studies. It reviews some of the major events in the maturation of the retina pertinent to the assembly of neuronal circuits. The book describes studies of neuronal assembly in order to demonstrate that adhesion-based neuronal assembly may be the most elaborated example of a wider class of morphogenetic phenomena categorized as ""adhesion-guided multicellular assembly"" systems. The remaining chapters discuss in vivo and in vitro studies on trophic interactions in retinal development and in retinal degenerations; cell motility in the retina; molecular properties of vertebrate rod cells; the role of cyclic nucleotides in the metabolism and function of the retina; and the cellular and molecular aspects of photosensitive membrane turnover.

目次

Contributors Preface Issues and Questions in Cell Biology of the Retina I. Introduction II. The Adult Retina III. The Developing Retina IV. The Pathological Retina V. Concluding Remark References The Development of Retinal Networks I. Introduction II. The Development of Retinal Layers III. Neurochemical Differentiation in the Retina IV. Maturation of Retinal Networks V. Summary References Differential Adhesion in Neuronal Development I. Introduction II. Neuronal Guidance Systems: Biological Studies III. Molecular Mechanisms of Adhesion IV. Neuronal Recognition and Differential Adhesion References Trophic Interactions in Retinal Development and In Retinal Degenerations. In Vivo and In Vitro Studies I. Introduction II. The Regulation of Neuronal Survival III. The Search for "Trophic" and Other Regulatory Factors IV. The Search for Molecules Controlling Survival and Differentiation of Retinal Neurons: In Vitro Studies V. Concluding Remarks References Cell Motility in the Retina I. Introduction II. The Structural Machinery: The Cytoskeleton III. Force-Producing Mechanisms IV. Vertebrate Retinomotor Movements V. Invertebrate Retinomotor Movements VI. Cytoskeleton and Motility in RPE Cells VII. Morphological Aspects of Retinal Synaptic Modulation VIII. Alignment of Photoreceptors IX. Concluding Remarks References Molecular Dynamics of the Rod Cell I. Structure of the Rod Cell II. Disk Membrane of the Rod Cell Outer Segment III. Rhodopsin: The Photoreceptor Protein IV. Light-Dependent Biochemistry of the Rod Cell References Cyclic Nucleotides in Retinal Function and Degeneration I. Introduction II. Cyclic Nucleotide Metabolism in Rod-Dominant Retinas III. Cyclic Nucleotides in Cone-Dominant Retinas IV. Abnormalities in Cyclic Nucleotide Metabolism in Retinal Degenerations V. Future Prospects References Photosensitive Membrane Turnover: Differentiated Membrane Domains and Cell-Cell Interaction I. Introduction II. Synthesis and Assembly of Photosensitive Membrane III. Disk Shedding and Phagocytosis IV. Regulation of Membrane Turnover V. Summary References Index

巻冊次

pt. 2 ISBN 9780120442768

内容説明

The Retina: A Model for Cell Biology Studies, Part II, is the second of a two-part series that details developments in the study of retinal cell biology. The book begins with a review of the current evidence for the role of putative neurotransmitters at particular synapses in the retina. It then discusses pre- and postsynaptic regulatory mechanisms; the interactions of neurotransmitter-neuromodulatory systems; and cellular effects of putative neurotransmitters and neuromodulators. This is followed by an introduction to vision psychophysics, showing its application in studying the functioning of cells in the retina. The remaining chapters discuss how the retinal pigment epithelium cell might be used as a model for studying biological problems of current interest; extracellular matrix molecules; concepts and controversies regarding the biology of endothelial cells, the key elements in the phenomenon of intraocular neovascularization; the use of genetic mutations and genetic mosaics for the study of the retina; and the retina as a regenerating organ.

目次

Contributors Preface Neurotransmitters and Neuromodulators in the Retina: Regulation, Interactions, and Cellular Effects I. Introduction II. Putative Neurotransmitters and Neuromodulators of Retinal Neurons III. Pre- and Postsynaptic Regulatory Mechanisms IV. Interactions of Neurotransmitters and Neuromodulators V. Cellular and Morphological Effects of Neurotransmitters and Neuromodulators VI. Concluding Remarks References Vision Psychophysics and Retinal Cell Biology I. Introduction II. The Systems Approach of Psychophysics III. Psychophysical Studies of Photoreceptor Physiology IV. Psychophysical Studies of Abnormal Retinal Physiology in Retinitis Pigmentosa V. Retinal Cell Biology from a Psychophysicist's Perspective References The Cell Biology of the Retinal Pigment Epithelium I. Summary of RPE Cell Structure and Functions II. Cellular Processes That Have Been Studied in the RPE III. Use of Cultured RPE Cells to Study Cellular Processes IV. Summary and Future Research References Extracellular Matrix Molecules: Their Importance in the Structure and Function of the Retina I. Introduction II. Extracellular Matrices III. Retinal Extracellular Matrices IV. Effects of Extracellular Matrix Molecules on Retinal Neurons V. Concluding Comments References Cell Biology and Biochemistry of Endothelial Cells and the Phenomenon of Intraocular Neovascularization I. Introduction II. New Vessels from Preexisting Vessels III. Steps in Capillary Formation IV. Maturation of the Vascular Bed V. Factors Influencing Capillary Sprout Formation VI. Conclusion References Genetic Mosaics as Tolls for the Study of the Retina I. A Modest Catalog of Known Mutations Affecting the Eye II. Genetic Mosaics: A Primer III. The Study of the Site of Gene Action IV. The Study of Cell Lineage V. The Study of Embryonic Retinal Development VI. General Conclusions References The Retina as a Regenerating Organ I. Introduction II. Characteristics of Regenerating Goldfish Retinal Ganglion Cells III. Conditions That Modify Axonal Outgrowth IV. Regulation of the Cell Body Reaction V. General Conclusions References Index

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詳細情報

• NII書誌ID(NCID): BA01227253
• ISBN:
  • 0120442752
  • 0120442760
• LCCN: 85023005
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Orlando ; Tokyo
• ページ数/冊数: 2 v.
• 大きさ: 24 cm
• 分類:
  • LCC : QP479
  • DC19 : 599/.01823
  • NDC8 : 496.34
  • NDLC : RA111
• 件名:
  • LCSH : Retina -- Cytology
  • MESH : Retina -- cytology
  • MESH : Retina -- physiology
• 親書誌ID:
  • BA00939576