Computer simulation in cell radiobiology
Author(s)
Bibliographic Information
Computer simulation in cell radiobiology
(Lecture notes in biomathematics, 74)
Springer-Verlag, c1988
- : us
- : gw
Available at 23 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Translation from Russian
Includes bibliographies
Description and Table of Contents
Description
The search for ways to overcome tumour radioresistance is a major problem of experimental and clinical radiation oncology. The diffi- culties involved in the attempts to solve this problem are a matter of common knowledge. In many a laboratory extensive studies are un- derway of factors determining tumour tissue response to irradiation and of methods for exerting directional effect upon those factors. Such studies have revealed that, at least at the cellular level, a considerable number of factors manifest themselves which are respon- sible for radiation effect (1] * Among those are: spatial heteroge- neity of tumour cell population producing radioresistant cell reser- ves (hypoxic cells of solid tumours); differing radiosensitivities of cell life cycle phases; intrinsic dynamics of the processes of radi- ation damage and postradiation cell recovery; induction of prolifera- tive processes in response to the death of some cells within the po- pulation; the stochastic nature of cell kinetics and complicated in- teraction between individual cell subpopulations corresponding to di- fferent tumour loci.
Questions arise as to whether the researchers are now in possession of adequate means for interpreting experimental findings and clinical evidence and whether there are procedures for performing complex analysis and predicting specific tumour responses to various irradiation regimens and to combined antitumoral effects, taking into account the complexities of the phenomena under study.
Table of Contents
Simulation in Cell Populations Kinetics.- A Simulation Model for In Vitro Kinetics of Normal and Irradiated Cells.- Simulation and Analysis Op Radiobiological Effects in Cell Cultures.- Simulation of Controlled Cell Systems.- The Properties of Cell Kinetics Indicators.- Conclusion.
by "Nielsen BookData"