Genetic engineering : principles and methods

著者

• Setlow, Jane K.
• Hollaender, Alexander

書誌事項

Genetic engineering : principles and methods

ed. by Jane K. Setlow and Alexander Hollaender

Plenum Press, 1979-

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• v. 24
• v. 25
• v. 26
• v. 27
• v. 28

注記

V. 9-: Edited by Jane K. Setlow

Publisher varies: v. 21-26: Kluwer Academic/Plenum Publishers → v. 27-: Springer

内容説明・目次

巻冊次

v. 1 ISBN 9780306401541

内容説明

This volume is the first of a series concerning a new tech- nology which is revolutionizing the study of biology, perhaps as profoundly as the discovery of the gene. As pointed out in the introductory chapter, we look forward to the future impact of the technology, but cannot see where it might take us. The purpose of these volumes is to follow closely the explosion of new tech- niques and information that is occurring as a result of the newly- acquired ability to make particular kinds of precise cuts in DNA molecules. Thus we are particularly committed to rapid publication. Jane K. Setlow Alexander Hollaender v INTRODUCTION AND HISTORICAL BACKGROUND 1 Maxine F. Singer CLONING OF DOUBLE-STRANDED cDNA . . 15 Argiris Efstratiadis and Lydia Vi11a-Komaroff GENE ENRICHMENT . . * * ...37 M. H. Edgell, S. Weaver, Nancy Haigwood and C. A. Hutchison III 51 TRANSFORMATION OF MAMMALIAN CELLS ...M. Wig1er, A. Pe11icer, R. Axel and S. Silverstein CONSTRUCTED MUTANTS OF SIMIAN VIRUS 40 73 D. Short1e, J. Pipas, Sondra Lazarowitz, D. DiMaio and D. Nathans STRUCTURE OF CLONED GENES FROM XENOPUS: A REVIEW 93 R. H. Reeder TRANSFORMATION OF YEAST 117 Christine lIgen, P. J. Farabaugh, A. Hinnen, Jean M. Walsh and G. R. Fink THE USE OF SITE-DIRECTED MUTAGENESIS IN REVERSED GENETICS 133 C. Weissmann, S. Nagata, T. Taniguchi, H. Weber and F. Meyer AGROBACTERIUM TUMOR INDUCING PLASMIDS: POTENTIAL VECTORS FOR THE GENETIC ENGINEERING OF PLANTS . 151 P. J. J. Hooykaas, R. A. Schi1peroort and A.

目次

and Historical Background.- Cloning if Double-Stranded cdna.- Gene Enrichment.- Transformation of Mammalian Cells.- Constructed Mutants of Simian Virus 40.- Structure of Cloned Genes from Xenopus: a Review.- Transformation of Yeast.- The Use of Site-Directed Mutagenesis in Reversed Genetics.- Agrobacterium Tumor Inducing Plasmids: Potential Vectors for the Genetic Engineering of Plants.- The Chloroplast, its Genome and Possibilities for Genetically Manipulating Plants.- Mitochondrial Dna of Higher Plants and Genetic Engineering.- Host-Vector Systems for Genetic Engineering of Higher Plant Cells.- Soybean Urease-Potential Genetic Manipulation of Agronomic Importance.- Acknowledgments.

巻冊次

v. 3 ISBN 9780306407291

目次

Constructed Mutants Using Synthetic Oligodeoxyribonucleotides as Site-Specific Mutagens.- Evolution of the Insertion Element IS1 That Causes Genetic Engineering of Bacterial Genomes in Vivo.- Applications of Molecular Cloning to Saccharomyces.- Cloning Retroviruses: Retrovirus Cloning?.- Repeated DNA Sequences in Drosophila.- Microbial Surface Elements: The Case of Variant Surface Glycoprotein (VSG) Genes of African Trypanosomes.- Mouse Immunoglobulin Genes.- The Use of Cloned DNA Fragments to Study Human Disease.- Physical Mapping of Plant Chromosomes by in Situ Hybridization.- Mutants and Variants of the Alcohol Dehydrogenase-1 Gene in Maize.- Developmentally Regulated Multigene Families in Dictyostelium Discoideum.- Computer Assisted Methods for Nucleic Acid Sequencing.

巻冊次

v. 4 ISBN 9780306411137

内容説明

Like many genetic engineers, I have recently been receiving the atten- tion of various venture capital companies, international drug houses and Members of Parliament. I will not discuss which of these approaches are most welcome, but it did cause me to consider the speed of advance in genetic engineering, and the implications of this rapid growth. There were few who anticipated it - only five years ago, most scientists thought applications would come at the end of the century, yet we see products such as insulin and interferon already available for clinical testing. In Europe in general and Britain in particular, this explosive growth in our own field has coincided with a general industrial depression and a marked reduction in funding for biomedical research. The brain drain from Britain is a serious matter, for we are losing the best of our younger scientists, on whom we would rely to train the next generation of molecular biologists. These volumes have come from British labs (mostly because I happen to be based in London, and my contacts and friends are here), and I feel that the quality of the con- tributions also shows that our current research is of a high standard.

目次

Plasmid and phage M13 cloning vectors.- I Introduction.- II Bacterial plasmids.- A Plasmid genes.- B Plasmid replication in E. coli.- C Transfer and mobilization.- III General purpose amplifiable vectors.- A Choice of vector.- B Choice of host cell.- C Selective markers.- D Regeneration of restriction sites.- E The pBR322 series.- IV Specialized vectors.- A Low copy number vectors.- B Vectors designed to detect transcription control signals.- C Direct selection vectors.- D Cosmids.- V Vectors designed to promote gene expression.- A Gene dosage.- B E. coli promoters.- C Fusion proteins.- VI Broad host range vectors.- A E. coli and Gram negatives.- B Bifunctional Bacillus-Escherichia vectors.- VII Single-stranded DNA phages as cloning vectors.- A Filamentous SS DNA phage biology.- B M13 vectors and their uses.- VIII Summary.- IX Acknowledgements.- X References.- Vectors based on bacteriophage lambda.- I Introduction.- II The lambda genome.- A The arrangement of the genes.- B The expression of lambda genes.- III Replication and maturation of lambda DNA.- A DNA structure.- B DNA packaging and size-selection.- C Maturation of recombinant phages.- D In vitro packaging of phage DNA.- IV The recognition of recombinant phages.- A Direct screens.- B Indirect screens.- C Positive selection for recombinant phages.- D Hybridization screening.- E Screens dependent on gene expression.- V The expression of genes cloned into lambda.- A Genes with their own promoter.- B Expression from PL.- C Expression from the late promoter.- D General considerations.- VI Making gene banks with lambda vectors.- VII Conclusions and future developments.- VIII Acknowledgements.- IX References.- Expression of cloned genes in eukaryotic cells using vector systems derived from viral replicons.- I Introduction.- A Why develop eukaryotic cloning systems?.- B What eukaryotic cloning systems are available?.- II Criteria for the design of animal virus vectors.- III Systems for the propagation of recombinant DNA molecules as virions.- A Simian virus 40.- B Human adenoviruses.- C Retroviruses.- IV Episomal vectors based on viral genomes.- A Introduction.- B Papillomavirus vectors.- C Episomal vectors based on Simian virus 40.- V Virus-based vectors carrying selectable genes.- A Introduction.- B The gpt system.- C The aminoglycoside phosphotransferase system.- D The dihydrofolate reductase system.- VI Vectors for the integration of exogenous DNA into chromosomal DNA.- VII Conclusions.- VIII Acknowledgements.- IX References.- A comprehensive list of cloned eukaryotic genes.- Key.- Genome clones.- cDNA clones.

巻冊次

v. 8 ISBN 9780306422775

目次

Regulation of Gene Activity During Conidiophore Development In Aspergillus Nidulans.- Regulation of Expression of Bacterial Genes for Bioluminescence.- Analysis of Genome Organization and Rearrangements by Pulse Field Gradient Gel Electrophoresis.- Structural Instability of Bacillus Subtilis Plasmids.- Geminiviruses, The Plant Viruses with Single-Stranded DNA Genomes.- The Use of Bacterial Plasmids in the Investigation of Genetic Recombination.- Shuttle Mutagenesis: A Method of Introducing Transposons into Transformable Organisms.- Genetic Advances in the Study of Rhizobium Nodulation.- Galactokinase Gene Fusion in the Study of Gene Regulation in E. Coli, Streptomyces, Yeast and Higher Cell Systems.- Structure and Function of the Signal Recognition Particle.- Alteration of the Structure and Catalytic Properties of Rubisco by Genetic Manipulation.- Electrophoresis of DNA in Denaturing Gradient Gels.- Caulimoviruses as Potential Gene Vectors for Higher Plants..- An Insect Baculovirus Host-Vector System for High-Level Expression of Foreign Genes.- Preparation of cDNA Libraries and The Detection of Specific Gene Sequences.- Construction of Human Chromosome Specific DNA Libraries: The National Laboratory Gene Library Project.- New Approaches to the Expression and Isolation of a Regulatory Protein.

巻冊次

v. 9 ISBN 9780306426636

目次

Gene Transfer in the Sea Urchin.- Properties and Uses of Heat Shock Promoters.- The Expression of Introduced Genes in Regenerated Plants.- Control of Maize Zein Gene Expression.- Dnase I Footprinting as an Assay for Mammalian Gene Regulatory Proteins.- Use of Gene Transfer in the Isolation of Cell Surface Receptor Genes.- A New Method for Synthesizing RNA on Silica Supports.- Activity Gels: Reformation of Functional Proteins from SDS-Polyacrylamide Gels.- Plasmid Vectors Carrying the Replication Origin of Filamentous Single-Stranded Phages.- High Level Production of Proteins in Mammalian Cells.- Plant Microinjection Techniques.- Genetic Transformation to Confer Resistance to Plant Virus Disease.- Alternative Splicing: Mechanistic and Biological Implications of Generating Multiple Proteins from a Single Gene.

巻冊次

v. 10 ISBN 9780306429910

内容説明

Genetic Engineering: Principles and Methods presents state-of-the-art discussions in modern genetics and genetic engineering. Recent volumes have covered gene therapy research, genetic mapping, plant science and technology, transport protein biochemistry, and viral vectors in gene therapy, among many other topics. Key features of Volume 27 include: - Identification and Analysis of Micrornas - Dormancy and the Cell Cycle - Long distance peptide and metal transport in plants - Signaling in plant response to temperature and water stresses - Nutrient transport and metabolism in plants - Salt Stress Signaling and Mechanisms of Plant Salt Tolerance - Gene cloning and expression - Assisted folding and assembly of proteins

巻冊次

v. 11 ISBN 9780306433399

内容説明

Eleven contributions address topics that include: DNA methylases; the application of antisense RNA technology to plants; molecular genetics of self incompatibility; pulsed-field gel electrophoresis. Annotation copyright Book News, Inc. Portland, Or.

巻冊次

v. 12 ISBN 9780306436161

目次

Folding of Eukaryotic Proteins Produced in EscherichiaColi.- Human Retinoblastoma Susceptibility Gene.- ?-Oligodeoxynucleotides (?-DNA): A New Chimeric Nucleic Acid Analog.- The Utility of Streptomycetes as Hosts for Gene Cloning.- From Footprint to Function: An Approach to Study Gene Expression and Regulatory Factors in Transgenic Plants.- Purification of Recombinant Proteins with Metal Chelate Adsorbent.- Determinants of Translation Efficiency of Specific mRNAs in Mammalian Cells.- The Polymerase Chain Reaction.- Regulation of Alternative Splicing.- Structure and Function of the Nuclear Receptor Superfamily for Steroid, Thyroid Hormone and Retinoic Acid.- Identification and Functional Analysis of Mammalian Splicing Factors.- The Genes Encoding Wheat Storage Proteins: Towards a Molecular Understanding of Bread-Making Quality and Its Genetic Manipulation.- Control of Translation Initiation in Mammalian Cells.- Electroporation of Bacteria: A General Approach to Genetic Transformation.- The Isolation and Identification of Cdna Genes by Their Heterologous Expression and Function.- Molecular Cloning of Genes Encoding Transcription Factors With the Use of Recognition Site Probes.

巻冊次

v. 13 ISBN 9780306439193

内容説明

Fifteen contributions on topics that include: the Mutator transposable element family of maize, protein phosphorylation, codon usage in primates, the role of nodulation genes in bacterium-plant communication, regulation of gene expression by epidermal growth factor, functions of intracellular protei

巻冊次

v. 14 ISBN 9780306442346

内容説明

This year's edition of the annual report of research in genetic engineering contains 15 papers. Among the topics are complications of RNA heterogeneity for the engineering of virus vaccines and antiviral agents, the molecular design of oligomeric channel proteins, and the physical mapping of human c

巻冊次

v. 15 ISBN 9780306445262

内容説明

The current volume covers human gene therapy, improving the nutritional value of maize, restriction-modification enzymes, and eight other subjects.

目次

• Application of Computational Neural Networks to the Prediction of Protein Structural Features
• S.R. Holbrook. Human Cellular Protein Patterns and their Link to Genome Data Mapping and Sequencing Data
• J.E. Celis, et al. Regulation of Translation in Plants
• A. Danon, et al. On the Origins, Structures, and Functions of Restriction-Modification Enzymes
• J. Heitman. Manipulation of Amino Acid Balance in Maize Seeds
• T. Ueda, J. Messing. Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides
• M.E. Selsted. Progress in the Cloning of Genes for Plant Storage Lipid Biosynthesis
• V.C. Knauf. Genes for Crop Improvement
• J. Bennett. Molecular Biology and Genetics of Protective Fungal Endophytes of Grasses
• C.L. Schardl, Z. An. Prospects for Human Gene Therapy
• A.B. Moseley, C.T. Caskey. The Use of Microparticle Injection to Introduce Genes into Animal Cells In vitro and In vivo
• S.A. Johnston, D.C. Tang. Index.

巻冊次

v. 16 ISBN 9780306447952

目次

• RNA Polymerase III Transcription in the Yeast Saccharomyces cerevisiae
• S. Buratowski. Lens Oncogenesis and Differentiation
• H. Westphal. Genetic Engineering of Cardiac Muscle Cells In vitro and In vivo
• S.J. Fuller, K.R. Chien. Genetic Control of Plant Ureases
• J.C. Polacco, M.A. Holland. Gene Discovery in Dictyostelium
• W.F. Loomis, et al. Transfer of YACs to Mammalian Cells and Transgenic Mice
• C. Huxley. Plant Genetic Engineering and Future Agriculture
• S. Riazuddin. Internal Initiation of mRNA Translation in Eukaryotes
• A. Kaminski, et al. Genetic Recombination Analysis Using Sperm Typing
• K. Schmitt, N. Arnheim. Genetic Regulation in Plant Pathogenic Pseudomonads
• D.K. Willis, et al. Defense-Related Gene Induction in Plants
• D. Alexander, et al. The P1 Vector System for the Preparation and Screening of Genomic Libraries
• N.S. Shepherd, D. Smoller. 3 additional articles. Index.

巻冊次

v. 17 ISBN 9780306450716

内容説明

Volume 17 of this highly acclaimed series features discussions on a new method of mapping and manipulating DNA with the use of RecA protein in combination with restriction enzymes, RNA pseudoknots, and platelet-derived growth factors and their receptors in cell differentiation and cell cycle control.

目次

The Molecular Biology of Nucleotide Excision Repair and Doublestrand Break Repair in Eukaryotes: A.R. Lehman. Manipulating and Mapping DNA with RecA-Assisted Restriction Endonuclease: (RARE) Cleavage: L.J. Ferrin. Molecular Studies on the Virulence of Listeria monocytogenes: M. Kuhn, W. Goebel. Indirect Use of Immobilized Metal Affinity Chromatography for Isolation and Characterization of Protein Partners: M. Sawadogo, M.W. Van Dyke. Structure and Function of RNA Pseudoknots: C.W.A. Pleij. Role of Molecular Chaperones in the Initiation of Plasmid DNA Replication: D.K. Chattoraj. Strucutre, Function and Engineering of Bacillus thurlngiensis Toxins: M.A. Thompson, et al. Uses for GAL4 Expression in Mammalian Cells: I. Sadowski. Protein Thiol Modification of Glyceraldehyde3Phosphate Dehydrogenase: B. Brune, E.G. Lapetina. The Genetics of Nuclear Migration in Fungi: S.M. Beckwith, et al. Structure and Function of the Platelet-derived Growth Factor Family and Their Receptors: K.C. Hart, et al. Recombination between Prokaryotic and Eukaryotic DNA: Integration of Agrobacterium tumefaciens TDNA into the Plant Genome: B. Tinland, B. Hohn. Metal Precipitation by Marine Bacteria: Potential for Biotechnological Applications: B.M. Tebo. Index.

巻冊次

v. 18 ISBN 9780306453717

内容説明

Volume 18 explores the latest advances in recombinant DNA molecule techniques and how they are revolutionizing basic research in biology. Chapters discuss obtaining good expression of genetically engineered pest-resistant genes introduced in crop plants, cloning DNAs containing palindromes, and identifying genes by 3' terminal exon trapping and much more.

目次

• Cloning and Characterization of DNAs with Palindromic Sequences
• D.R.F. Leach. DNA Isolation, Manipulation and Characterization from Old Tissues
• R. DeSalle, E. Bonwich. Growth Factors and Neural Connectivity
• S. McFarlane, C.E. Holt. Gene Identification by 3' Terminal Exon Trapping
• D.B. Krizman. Engineering Transgenes for Use in the Mammary Gland
• S. Yarus, et al. Problems that Can Limit the Expression of Foreign Genes in Plants: Lessons to Be Learned from B.t. Toxin Genes
• S.H. Diehn, et al. Renaturation and Reconstitution of Functional Holoenzyme from Recombinant Subunits of Casein Kinase II Expressed as Inclusion Bodies in E. coli
• W.J. Lin, et al. Plant Acyl-ACP Thioesterases: Chainlength Determining Enzymes in Plant Fatty Acid Biosynthesis
• T. Voelker. Genetic Engineering of an Insect Parasite
• R. Gaugler, S. Hashmi. The Stop Signal Controls the Efficiency of Release Factor-mediated Translational Termination
• W.P. Tate, et al. Mechanism of Replication and Copy Number Control of Plasmids in Grampositive Bacteria
• S.A. Khan. Pathways of Protein Remodeling by Escherichia coli Molecular Chaperones
• M. Pak, S.H. Wickner. Pheromones and Pheromone Receptors as Matingtype Determinants in Basidiomycetes
• L.J. Vaillancourt, C.A. Raper. Synthesis and Applications of Phosphopeptides
• K. Sakaguchi, et al. Index.

巻冊次

v. 19 ISBN 9780306456817

内容説明

The newest installment in this superb series presents descriptions of the latest DNA recombinants molecule technology. The text combines reports on basic research in genetics with discussions of specific new industrial applications (as well as refinements of older ones) that are likely to prove highly profitable in the years to come.

目次

• Novel Approaches to Engineering Disease Resistance in Crops
• K.M.M. Swords. The Structure of Plant Gene Promoters
• T.J. Guilfoyle. Plasmid Stabilization by Post-Segregational Killing
• K. Gerdes, et al. Pathways and Genes Involved in Cellulose Synthesis
• Y. Kawagoe, D.P. Delmer. Conjugative Transposons
• A.A. Salyers, N.B. Shoemaker. Termination of DNA Replication in Prokaryotic Chromosomes
• D. Bastia, et al. Regulation of Protein Degradation in Plants
• J. Callis. Genetic Engineering of Oilseeds for Desired Traits
• A.J. Kinney. Specificity of Receptor Tyrosine Kinase Signaling Pathways: Lessons from Drosophila
• W. Li, N. Perrimon. Switching on Gene Expression: Analysis of the Factors that Spatially and Temporally Regulate Plant Gene Expression
• L. Meisel, E. Lam. Nucleic Acid Transport in Plant-Pathogen Interactions
• R. Lartey, V. Citovsky. Leaf Senescence: Gene Expression and Regulation
• L.M. Weaver, et al. Production and Analysis of Transgenic Mice Containing Yeast Artificial Chromosomes
• K.R. Peterson. Comparative Molecular Analysis of Genes for Polycyclic Aromatic Hydrocarbon Degradation
• G.J. Zylstra, et al. Recognition and Signaling in Plant-Pathogen Interactions: Implications for Genetic Engineering
• M. Lawton. Index.

巻冊次

v. 20 ISBN 9780306459115

目次

• Agrobacterium-Mediated Horizontal Gene Transfer
• C.I. Kado. Computer-Assisted Methods for the Identification of Polymerase II Promoters
• I. Reuter, et al. Retroviral cDNA Integration: Mechanism, Applications and Inhibition
• M.S.T. Hansen, et al. The Signal Transduction of Motion and Antigen Recognition: Factors Affecting T Cell function and Differentiation
• S.C. Bunnell, L.J. Berg. Synthetic DNA Arrays
• A. Blanchard. Detection of Single Nucleotide Variations
• P.-Y. Kowk, X. Chen. Antisense: A Key Tool for Cell and Developmental Studies in Dictyostelium
• R.H. Gomer. Antisense in Abundance: The Ribosome as a Vehicle for Antisense RNA
• R. Sweeney, et al. Salinity Tolerance-Mechanisms, Models and the Metabolic Engineering of Complex Traits
• D.E. Nelson, et al. Biochemistry, Molecular Biology and Regulation of Starch Synthesis
• J. Preiss, M.N. Sivak. Genetic Engineering and the Expression of Foreign Peptides or Proteins with Plant Virus-Based Vectors
• C. Lacomme, et al. Cloning and Expression of Large Mammalian cDNAs: Lessons from ATM
• Y. Shiloh, et al. The Use of Genetically Engineered Cells in Drug Discovery
• G. Loeber, R. Schnitzer. Molecular Engineering of Monoterpene Production
• C.D. Haudenschild, R.B. Croteau. Index.

巻冊次

v. 21 ISBN 9780306461842

内容説明

Aspects of genetic engineering research emphasized in this volume are applications to plants (crop plants and grass, both important for human needs) and new methodologies, such as Tar cloning, which make it much easier to isolate specific regions from complex genomes. Another subject discussed is linear DNA replication of prokaryotes.

目次

• Acknowledgment. Nuclear Plasmids of Dictyostelium
• J.E. Hughes, D.L. Welker. The Translation Initiation Signal in E. coli and its Control
• E. Fuchs. Direct Isolation of Specific Chromosomal Regions and Entire Genes by Tar Cloning
• V. Larionov. Regulation of Lysine and Threonine Metabolism in Plants
• R. Amir, G. Galili. Genetic Engineering of Plant Chilling Tolerance
• J. Tokuhisa, J. Browse. Role of Bacterial Chaperones in DNA Replication
• I. Konieczny, M. Zylicz. Transformation of Cereals
• R. Bilang, et al. Mechanisms of Initiation of Linear DNA Replication of Prokaryotes
• M. Salas. Diverse Regulatory Mechanisms of Amino Acid Biosynthesis in Plants
• K.J. Denby, R.L. Last. Forage and Turf-Grass Biotechnology: Principles, Methods and Prospects
• J.W. Forster, G.C. Spangenberg. Informatics Needs of Plant Molecular Biology
• M. Polacco. Index.

巻冊次

v. 22 ISBN 9780306464737

内容説明

This volume, as with the previous books in the series, presents state-of-the-art discussions in genetics and genetic engineering by focusing on plant science and technology, agriculture, cell biology, and medical research.

目次

• Acknowledgement. Post-Transcriptional Light Regulation of Nuclear-Encoded Genes
• M.E. Petracek, W.F. Thompson. Novel Methods of Introducing Pest and Disease Resistance To Crop Plants
• J. Bruenn. Targeting Gene Repair in Mammalian Cells Using Chimeric Oligonucleotides
• E.B. Kmiec, et al. Exploring the Mechanism of Action of Insectidal Proteins by Genetic Engineering Methods
• J.L. Jenkings, D.H. Dean. Enzyme Stabilization by Directed Evolution
• A. Gershenson, F.H. Arnold. Et-Cloning: Think Recombination First
• J.P.P. Muyrers, et al. Growth and Genetic Modification of Human beta-Cells and beta-Cell Precursors
• G.M. Beattie, et al. Elucidation of Biosynthetic Pathways by Retrodictive/Predictive Comparison of Isotopomer Patterns Determined by NMR Spectroscopy
• W. Eisenreich, A. Bacher. Are Gene Silencing Mutants Good Tools for Reliable Transgene expression or Reliable Silencing of Endogenous Genes in Plants? P. Mourrain, et al. Manipulating Plant Viral RNA Transcriptional Signals
• C.L. Hemenway, S.A. Lommel. Genetic Engineering Strategies for Hematologic Malignancies
• T.J. Kipps. Telomerase and Cancer
• M.O. Robinson. Index.

巻冊次

v. 23 ISBN 9780306466458

内容説明

Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4).

目次

• Evolution of Transport Proteins
• M.H. Saier, Jr. Mechanisms of Apoptosis Repression
• C.C.Q. Vu, J.A. Cidlowski. Cytokine Activation of Transcription
• K.A. Mowen, M. David. Enzymatic Approaches to Glycoprotein Synthesis
• P. Sears, et al. Vector Design and Development of Host System for Pseudomonas
• H.P. Schweizer, et al. Genetic and Biochemical Studies on the Assembly of an Enveloped Virus
• T.L. Tellinghuisen, et al. Enzyme and Pathway Engineering for Suicide Gene Therapy
• M.E. Black. Deconstructing a Conserved Protein Family: the Role of MCM Proteins in Eukaryotic DNA Replication
• S.G. Pasion, S.L. Forsburg. Expression of Foreign Genes in the Yeast Pichiapastoris
• G.P. Lin Cereghino, et al. Protein Splicing and its Applications
• I. Giriat, et al. Global Transcript Expression Profiling By Serial Analysis of Gene Expression (SAGE)
• H.S. Scott, R. Chrast. Index.

巻冊次

v. 24 ISBN 9780306472800

内容説明

Genetic Engineering, Volume 24 contains discussions of contemporary and relevant topics in genetics, including: -Gene silencing: principles and applications, -Integrins and the myocardium, -Plant virus gene vectors: biotechnology and applications in agriculture and medicine, -Novel approaches to controlling transcription, -Use of DNA polymorphisms in genetic mapping, -Application of FLP/FRT site-specific DNA recombination system in plants. This principles and methods approach to genetics and genetic engineering is essential reading for all academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in this continuously emerging field.

目次

• Application of FLP/FRT Site-Specific DNA Recombination System in Plants
• H. Luo, A.P. Kausch. Protein Quality Control in Bacterial Cells: Integrated Networks of Chaperones and ATP-Dependent Proteases
• J.M. Flanagan, M.C. Bewley. Regulation of the Ras-MAPK Pathway at the level of Ras and Raf
• H. Vikis, K.-L. Guan. Plant Virus Gene Vectors: Biotechnology Applications in Agriculture and Medicine
• K.-B.G. Scholthof, et al. Integrins and the Myocardium
• S.-Y. Shai, et al. Foreign DNA: Integration and Expression in Transgenic Plants
• R.M. Twyman, et al. Novel Approaches to Controlling Transcription
• T.D. Schaal, et al. The Use of DNA Polymorphisms in Genetic Mapping
• C.A. Cullis. Import of Nuclear-Encoded RNAs into Yeast and Human Mitochondria: Experimental Approaches and Possible Biomedical Applications
• N. Entelis, et al. An Introduction to 13C Metabolic Flux Analysis
• W. Wiechert. Gene Silencing - Principles and Application
• C. Horser, et al. Index.

巻冊次

v. 25 ISBN 9780306477768

内容説明

Genetic Engineering, Volume 25 contains discussions of contemporary and relevant topics in genetics, including: - Genotyping by Mass Spectrometry; - Development of Targeted Viral Vectors for Cardiovascular Gene Therapy; - Practical Applications of Rolling Circle Amplification of DNA Templates; - Bacterial ION Channels; - Applications of Plant Antiviral Proteins; - The Bacterial Scaffoldin: Structure, Function and Potential Applications in the Nanosciences. This principles and methods approach to genetics and genetic engineering is essential reading for all academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in this continuously emerging field.

目次

Genotyping by Mass Spectrometry.- Development of Targeted Viral Vectors for Cardio-Vascular Gene Therapy.- Practical Applications of Rolling Circle Amplification of DNA Templates.- Structural Analyses of Living Plant Nuclei.- Bacterial Ion Channels.- Functional Analysis of Promoter Elements in Plants.- Applications of Plant Antiviral Proteins.- Biosynthesis and Metabolism of Glutathione in Plants.- Delitto PerfettoTargeted Mutagenesis in Yeast with Oligonucleotides.- The Bacterial Scaffoldin: Structure, Function and Potential Applications in the Nanosciences.- Hybrid Peptide-Polyketide Natural Products: Biosynthesis and Prospects Towards Engineering Novel Molecules.- Characterization of Protein Structure and Function at Genome Scale using a Computational Prediction Pipeline.

巻冊次

v. 26 ISBN 9780306485749

目次

Arabidopsis as a Genetic Model for Interorganellle Lipid Trafficking.- Protein Sequence Database Methods.- Properties and Applications of Cell-Penetrating Peptides.- Detection of Topological Patterns in Protein Networks.- Dna Microarrays: Methodology, Data Evaluation and Applications in the Analysis of Plant Defense Signaling.- Approaches for Identification of Fungal Genes Essential for Plant Disease.- Genetic Mapping in Forest Trees: Markers, Linkage Analysis and Genomics.- The Production of Long Chain Polyunsaturated Fatty Acids in Transgenic Plants.- Investigating in Situ Natural Genetic Transformation of Acinetobacter SP. BD413 in Biofilms with Confocal Laser Scanning Microscopy.- The Path in Fungal Plant Pathogenicity: Many Opportunities to Outwit the Intruders?.- Analysis and Annotations of Microbial Genome Sequences.- Brain Plasticity and Remodeling of Ampa Receptor Properties by Calcium-Dependent Enzymes.- Gene Regulation by Tetracyclines.

巻冊次

v. 27 ISBN 9780387258553

内容説明

Genetic Engineering: Principles and Methods presents state-of-the-art discussions in modern genetics and genetic engineering. Recent volumes have covered gene therapy research, genetic mapping, plant science and technology, transport protein biochemistry, and viral vectors in gene therapy, among many other topics. Key features of Volume 27 include: - Identification and Analysis of Micrornas - Dormancy and the Cell Cycle - Long distance peptide and metal transport in plants - Signaling in plant response to temperature and water stresses - Nutrient transport and metabolism in plants - Salt Stress Signaling and Mechanisms of Plant Salt Tolerance - Gene cloning and expression - Assisted folding and assembly of proteins

目次

Identification and Analysis of Micrornas.- Dormancy and the Cell Cycle.- The OPT Family Functions in Long Distance Peptide and Metal Transport in Plants.- Phospholipid-Derived Signaling in Plant Response to Temperature and Water Stresses.- Anionic Nutrient Transport in Plants: The Molecular Basis of Sulfate Transporter Gene Family.- Purification of Protein Complexes by Immunoaffinity Chromotography: Application to Transcription Machinery.- Biogenesis of Iron-Sulfur Cluster Proteins in Plastids.- Iron Transport and Metabolism in Plants.- Salt Stress Signaling and Mechanisms of Plant Salt Tolerance.- Strategies for High-Throughput Gene Cloning and Expression.- Molecular Roles of Chaperones in Assisted Folding and Assembly of Proteins.- Engineering Plants for Increased Nutrition and Antioxidant Content through the Manipulation of the Vitamin E Pathway.- Index.

巻冊次

v. 28 ISBN 9780387338408

内容説明

This book, published by Springer since 1979, presents state-of-the-art discussions in modern genetics and genetic engineering. This focus affirms a commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Recent volumes have covered gene therapy research, genetic mapping, plant science and technology, transport protein biochemistry, and viral vectors in gene therapy, among other topics.

目次

Regulation of Plant Intercellular Communication Via Plasmodesmata.- Root-Knot and Cyst Nematode Parasitism Genes: The Molecular Basis of Plant Parasitism.- Mutagenesis of Human p53 Tumor Suppressor Gene Sequences in Embryonic Fibroblasts of Genetically-Enginered Mice.- Salicylic Acid-, Jasmonic Acid- and Ethylenemediated Regulation of Plant Defense Signaling.- Proximity Ligation: A Specific and Versatile Tool for the Proteomic Era.- Protein Overexpression in Mammalian Cell Lines.- A High-Throughput Approach To Protein Structure Analysis.- New Mass-Spectrometry-Based Strategies For Lipids.- Paired-End Genomic Signature Tags: A Method for the Functional Analysis of Genomes and Epigenomes.

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詳細情報

• NII書誌ID(NCID): BA05860473
• ISBN:
  • 0306401541
  • 0306404478
  • 0306407299
  • 030641113X
  • 0306413825
  • 0306417103
  • 030642004X
  • 0306422778
  • 0306426633
  • 0306429918
  • 0306433397
  • 0306436167
  • 0306439190
  • 0306442345
  • 0306445263
  • 0306447959
  • 0306450712
  • 0306453711
  • 0306456818
  • 0306459116
  • 0306461846
  • 030646473X
  • 0306466457
  • 0306472805
  • 0306477769
  • 0306485745
  • 0387258558
  • 0387338403
• LCCN: 79644807
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: v.
• 大きさ: cm
• 分類:
  • DC21 : 575.1
  • LCC : GH442.G454
• 件名:
  • LCSH : Genetic engineering -- Collected works