Genetic mosaics and chimeras in mammals


    • Russell, Liane B.
    • Symposium on Genetic Mosaics and Chimeras, Gatlinburg, Tenn., 1978
    • Oak Ridge National Laboratory. Biology Division


Genetic mosaics and chimeras in mammals

edited by Liane B. Russell

(Basic life sciences, v. 12)

Plenum Press, c1978

大学図書館所蔵 件 / 14



"The chapters ... are based on talks presented at the Symposium on 'Genetic Mosaics and Chimeras' held April 3-6, 1978, at Gatlinburg, Tennessee ... sponsored by the Biology Division of the Oak Ridge National Laboratory as part of its annual research conference series."

Includes bibliographies and index



Use of Chimeras and Cell Aggregations to Study Developmental Potency, Gene Expression, Control of Phenotype, and Tumor Origin.- Reversion of malignancy and normalized differentiation of teratocarcinoma cells in chimeric mice.- Viable chimeras produced from normal and parthenogenetic mouse embryos.- Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division.- Growth control in chimeras.- Attempts at locating the site of action of genes affecting behavior.- Fine structure of cells in embryos chimeric for mutant genes at the T/t locus.- An analysis of differentiation in coaggregation cultures between mouse neuronal and tumor cells.- The use of mosaics and experimental chimeras to study the pathogenesis of neoplasia.- Antibodies to allozymes as potential cell markers for chimeric mouse studies.- Use of Chimeras and Mutational or Disjunctional Mosaics to Study Gamete Differentiation, Sexual Development, and Origin of the Germline.- Reproduction in single-sex chimeras.- Germ cells in XX ? XY mouse chimeras.- Use of the sex reversed gene (Sxr) to investigate functional sex reversal and gonadal determination in mammals.- Why not androgynes among mammals?.- Cell interactions in the sex organs of sex reversed mice heterozygous for testicular feminization.- Spontaneous sex mosaicism in BALB/cWt mice.- Evidence from mutable genes concerning the origin of the germ line.- X Chromosome Inactivation and Derepression.- Bimodal distribution of ?-galactosidase activities in mouse embryos.- Biochemical studies on X-chromosome activity in preimplantation mouse embryos.- Hypoxanthine guanine phosphoribosyl transferase expression in early mouse development.- The direct demonstration of an X-chromosome dosage effect prior to inactivation.- Use of teratocarcinoma stem cells as a model system for the study of X-chromosome inactivation in vitro.- The stability of X-chromosome inactivation: studies with mouse-human cell hybrids and mouse teratocarcinomas.- Studies of human-mouse cell hybrids with respect to X-chromosome inactivation.- X-Chromosome Nonrandomness: Imprinting, Selection.- Preferential inactivation of the paternally derived X chromosome in mice.- Preferential expression of the maternally derived X chromosome in extraembryonic tissues of the mouse.- In search of nonrandom X inactivation: studies of the placenta from newborns heterozygous for glucose-6-phosphate dehydrogenase.- The use of mouse X-autosome translocations in the study of X-inactivation pathways and nonrandomness.- Selection and cell communication as determinants of female phenotype.- Mathematical and Statistical Analyses of Mosaic Patterns.- Clonal growth versus cell mingling.- Combinatorial and computer analysis of random mosaics.- Data analysis of four X-chromosome inactivation experiments.

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