Proteases II : potential role in health and disease
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Proteases II : potential role in health and disease
（Advances in experimental medicine and biology, v. 240）
Plenum Press, c1988
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"Proceedings of the Second International Symposium on Proteases: Potential Role in Health and Disease, held May 17-20, 1987 in Rothenburg ob der Tauber, Federal Republic of Germany"--T.p. verso
Includes bibliographies and index
内容説明・目次
目次
- I Physiology and Pathophysiology of Proteases and Their Inhibitors.- Aspartic Proteinases and Inhibitors for their Control in Health and Disease.- Human Neutral Endopeptidase 24.11 (NEP, Enkephalinase)
- Function, Distribution and Release.- Neutrophil Elastase and Cathepsin G: Structure, Function and Biological Control.- The Degradation of Collagen by a Metalloproteinase from Human Leucocytes.- Plasma Membrane Proteases as Useful Tool in Histochemical Toxicology.- Activation of Leukocytes During Prolonged Physical Exercise.- Inhibition of Human Neutrophil Elastase by Polyguanylic Acid and other Synthetic Polynucleotides.- Inhibition of Human Neutrophil Elastase by Acid-Soluble Inter-Alpha-Trypsin Inhibitor.- Development of Eglin c as a Drug: Pharmacokinetics.- Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology.- Inhibition of Human Chymotrypsin-Like Proteases by Alpha-1-Proteinase Inhibitor and Alpha-1-Antichymotrypsin.- Immunoreactive Pancreatic Secretory Trypsin Inhibitor in Gastrointestinal Mucosa.- II Proteases and Lung.- Semisynthetic Inhibitors of Human Leukocyte Elastase and their Protective Effect on Lung Elastin Degradation in vitro.- Human Bronchial Proteinase Inhibitor: Rapid Purification Procedure and Inhibition of Luecocyte Elastase in Presence and in Absence of Human Lung Elastin.- Functional Studies of Human Secretory Leucocyte Protease Inhibitor.- The Role of Chymase in Ionophore-Induced Histamine Release from Humanm Pulmonary Mast Cells.- Proteolytic Activities in Bronchoalveolar Lavage Fluid Correlate to Stage and Course of Interstitial Lung Disease.- Behaviour of Angiotensin Converting Enzyme, Hydroxyproline and some Protease Inhibitors in Pulmonary Sarciodosis.- Experemental Studies on the Adult Respiratory Distress Syndrome: Elastase Infusion in Normal and Agranulocytic Minipigs.- III Proteases and Liver.- Arginylation, Surface Hydrophobicity and Degradation of Cytosol Proteins from Rat Hepatocytes.- Proteinases Inhibitors as Acute Phase Reactants: Regulation of Synthesis and Turnover.- Regulation of Proteinase Activity by High Molecular Weight Inhibitors: Biosynthesis of Rat Alpha-Macroglobulins.- Induction of the Proteinase Inhibitor Alpha-2-Macroglobulin in Rat Hepatocytes by a Monocyte-Derived Factor.- Astrocytes Synthesize and Secrete ?2-Macroglobulin: Differences Between the Regulation of ?2-Macroglobulin Synthesis in Rat Liver and Brain.- Characterization of Different Forms of Dipeptidyl Peptidase IV from Rat Liver and Hepatoma by Monoclomal Antibodies.- IV Muscle Protein Degradation.- Non-Lysosomal, High-Molecular-Mass Cysteine Proteinases from Rat Skeletal Muscle.- Role of Factors Derived from Activated Macrophages in Regulation of Muscle Protein Turnover.- Responses of Lysosomal and Non-Lysosomal Proteases to Unloading of the Soleus.- Capthesin B and D Activity in Human Skeletal Muscle in Disease States.- Hormonal Regulation of Muscle Protein Catabolism in Acutely Uremic Rats: Effect of Adrenalectomy and Parathyroidectomy.- V Proteases, Kidney and Uremia.- Relation Between Urinary Proteinases and Proteinuria in Rats with a Glomerular Disease.- Characterization and Clinical Role of Glomecular and Tubular Proteases from Human Kidney.- Effect of Glomerural Proteinuria on the Activities of Lysosomal Proteases in Isolated Segments of Rat Proximal Tubule.- Meprin Phenotype and Cyclosporin A Toxicity in Mice.- Potential Role of Lysosomal Proteases in Gentamicin Neprotoxicity.- Urinary Proteinase Activity in Patiens with Acute Renal Failure after Trauma and Kidney Transplantation.- Mechanisms for Activation of Proteolysis in Uremia.- Evidence for the Role of Proteinases in Uremic Catabolism.- Eglin C Fails to Reduce Catabolism in Acutely Uremic Rats.- Evidence for Protein Split Produts in Plasma of Patients with Acute Renal Failure.- Proteases and Antiproteases at Different Vascular Sites in Renal Failure.- Protease Histochemistry in Normal and Uremic Rats.- Total Kininogen Levels, Plasma Renin Activity, Dopamine-Beta-Hydroxylase and Plasma Catecholamines in Chronic and Acute Renal Failure.- VI Proteolytic Enzymes During Extracorporal Circulation.- Biocompatibility of Dialysis Membranes: Factor H Binding Correlates Inversely with Complement Activation Indicating a Local Imbalance of Involved Proteases/Anti-Proteases.- Hemodialysis with Curophane Membranes Leads to Alternation of Granulocyte Oxidative Metabolism and Leukocyte Sequestion in the Lung.- Effect of Immunsuppresion on the Release of Main Granulocyte Components: In Vivo and in Vitro Studies.- Release of Granulocyte Proteins During Cardiopulmonary Bypass: Effect of Different Pharmacological Interventions.- Significant Role of Protease Inhibition by Aprotinin in Myocardial Protection from Prolonged Cardioplegia with Hypotermia.- Fibrinolysis Caused by Cardio-Pulmonary Bybass and Shed Mediastinal Blood Retransfusion - Is it of Clinical Relevance?.- VII Proteinases in Catabolic States.- Nutrition and Protease Activity.- Insulin Degradation after Injury in Man.- Endotoxin Abolishes the Induction of Alpha-2-Macroglobulin Synthesis in Cultured Human Monocytes Indicating Inhibition of the Terminal Monocyte Maturation into Macrophages.- Local and General Defence Mechanisms in Bacterial and Chemical Peritonitis.- Deficient Phagocytosis Secondary to Proteolytic Breakdown of Opsonins in Peritonitis Exudate.- Proteolysis and Lipid Peroxidation - Two Aspects of Cell Injury in Experimental Hypovolemic-Traumatic Shock.- Plasma Levels of Elastase 1 Protease Inhibitor Complex in the Monitoring of Ards and Multi-Organ Failure - A Summary of Three Clinical Trials.- PMN Elastase and Leukocyte Neutral Proteinase Inhibitor (LNPI) from Granulocytes as Inflammation Markers in Experimental-Septicemia.- Plasma Derivative Replacement Therapy in Diss.Intranvasc.Coag. (DIC) Induced by Septic Disorders with highly Elevated Elastase Alpha-1-AT-Complexes.- Neutrophil Elastase, Trhombin and Plasmin in Septic Shock.- Elastase-Alpha-1-Proteinase Inhibitor: An Early Indicator of Septicemia and Bacterial Meningitis in Childhood.- Serum Pancreatic Secretory Trypsin Inhibitor (PSTI) in Seriuosly Injured and Septic Patients.- Changes in PMN-Elastase in Blood and in Renal and Plasma Kallikrien-Kinin Systems after Severe Burn Injury.- Serum Pancreatic Seccretory Trypsin Inhibitor (PSTI) in Patients with Inflammatory Diseases.- The Effect of Aprotinin Administration on the Intraoperative Histamine Release and Haemostatic Disorders.- Increased Mortality in Septic Rats after Leupeptin Application.- Lysosomal Enzymes and Granulocyte Elastase in Synovial Fluid after Multiple Traumatic Injuries.- A Serine Proteinase Inhibitor in Human Articular Cartilage Possible Role in the Pathogenesis of Inflammatory Joint Diseaeses.- Detection of Granulocyte Elastase Specific IgG Split Products in Rheumatoid Synovial Fluid.- VIII Proteases and Malignoma.- The T Cell Specific Serine Proteinase TSP-1: Biochemical Characterization, Genetic Analysis, and Functional Role.- Pancreatic Ssecretory Trypsin Inhibitor in Cancer.- Proteases and Antiproteases in Ascites-Differentiation of Malignant and Nonmalignant Ascites and Prediction of Coagulopathy in Ascites Retransfusion.- Alpha-1-Antitrypsin and Alpha-1-Antichymotrypsin Serum Level in Relation to Staging and Postoperative Clinical Course of Human Colorectal Cancer.- Inhibition of Proteases During Extracorporeal Extremity Perfusion.
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