Molecular mechanisms for repair of DNA

著者

• Hanawalt, Philip C.
• Setlow, Richard B. (Richard Burton)

書誌事項

Molecular mechanisms for repair of DNA

edited by Philip C. Hanawalt and Richard B. Setlow

（Basic life sciences, v. 5）

Plenum Press, c1975

• Part A
• Part B

注記

"Outgrowth of a workshop conference on Molecular Mechanisms for Repair of DNA held at Squaw Valley, California, in February 1974."

Includes bibliographies and index

内容説明・目次

巻冊次

Part A ISBN 9780306365935

内容説明

An "age" has passed in the 40 years since we first observed recovery from radiation damage in irradiated bacteria. During the early 1930s, we had been discussing the possibility of rapid changes after radiation exposure with Farring- ton Daniels, Benjamin Duggar, John Curtis, and others at the University of Wisconsin. After working with living cells, we had concluded that organisms receiving massive insults must have a wide variety of repair mechanisms available for restoration of at least some of the essential properties of the cell. The problem was how to fmd and identify these recovery phenomena. At that time I was working on a problem considered to be of great importance-the existence of the so-called mitogenetic rays. Several hundred articles and a score of books had already appeared dealing with mitogenetic rays, a type of radiation that was thought to exist in the shorter ultraviolet region. Our search for mitogenetic rays necessitated the design of experiments of greatest sensitivity for the detection of ultraviolet. It was vital that conditions be kept as constant as possible during exposure. All the work was done at icewater temperature (3-5 C) during and after exposure. We knew that light was an important factor for cell recovery, so all our experiments were done in dim light, with the plated-out cells being covered with dark cloth. Our statements on the effect of visible light stimulated Kelner to search for "photoreactivation' (as it was later called).

目次

I. Repairable Damage in DNA.- 1. Repairable Damage in DNA: Overview.- 2. The Nature of the Alkylation Lesion in Mammalian Cells.- 3. "Excision" of Bases from DNA Methylated by Carcinogens in Vivo and Its Possible Significance in Mutagenesis and Carcinogenesis.- 4. Alkali-Labile Lesions in DNA from Cells Treated with Methylating Agents, 4-Nitroquinoline-N-oxide, or Ultraviolet Light.- 5. Apurinic and Apyrimidinic Sites in DNA.- 6. Maintenance of DNA and Repair of Apurinic Sites.- 7. DNA Turnover and Strand Breaks in Escherichia coli.- 8. Excision-Repair of ?-Ray-Damaged Thymine in Bacterial and Mammalian Systems.- 9. Formation of Dimers in Ultraviolet-Irradiated DNA.- 10. An Enzymatic Assay for Pyrimidine Dimers in DNA.- II. Enzymatic Photoreactivation.- 11. Enzymatic Photoreactivation: Overview.- 12. Kinetics of Photoreactivation.- 13. Purifying the Escherichia coliPhotoreactivating Enzyme.- 14. The Human Leukocyte Photoreactivating Enzyme.- 15. Photorepair of RNA.- III. Dark Repair in Bacteriophage Systems.- 16. Dark Repair in Bacteriophage Systems: Overview.- 17. Enzymic Mechanism of Excision-Repair in T4-Infected Cells.- 18. The Repair of Ultraviolet Damage by Phage T4: The Role of the Early Phage Genes.- 19. Repair of IIeteroduplex DNA in Bacteriophage T4.- 20. Recovery of Phage ? from Ultraviolet Damage.- IV. Enzymology of Excision-Repair in Bacteria.- 21. Enzymology of Excision-Repair in Bacteria: Overview.- 22. The Escherichia coliUV Endonuclease (Correndonuclease II).- 23. Endonuclease II of Escherichia coli.- 24. Endonuclease III: An Endonuclease from Escherichia coli That Introduces Single Polynucleotide Chain Scissions in Ultraviolet-Irradiated DNA.- 25. An Escherichia coliEndonuclease Which Acts on X-Irradiated DNA.- 26. Substrate Specificity of Micrococcus luteus UV Endonuclease and Its Overlap with DNA Photolyase Activity.- 27. Two Temperature-Sensitive polA Mutants: An Approach to the Rolein Vivoof DNA Polymerase I.- 28. The Role of DNA Polymerase I in Excision-Repair.- 29. Involvement of Escherichia coliDNA Polymerase-I-Associated 5??3? Exonuclease in Excision-Repair of UV-Damaged DNA.- 30. Exonuclease VII of Escherichia coli.- 31. Enzymatic Repair of UV-Irradiated DNA in Vitro.- 32. Repair Replication in Permeabilized Escherichia coli.- 33. Requirement for uvrAB Function for Postirradiation DNA Synthesis in Vitro.- 34. DNA Polymerase II-Dependent DNA Synthesis in Toluenized Bacillus subtilis Cells.- V. Repair by Genetic Recombination in Bacteria.- 35. Repair by Genetic Recombination in Bacteria: Overview.- 36. Genetic Exchanges Induced by Structural Damage in Nonreplicating Phage ? DNA.- 37. The Beginning of an Investigation of the Role of recF in the Pathways of Metabolism of Ultraviolet-Irradiated DNA in Escherichia coli.- 38. The Degradation of Duplex DNA by the recBC DNase ofEscherichia coli.- 39. Analysis of Temperature-Sensitive recB and recC Mutations.- 40. Recombination and Postreplication Repair.- 41. Ultraviolet-Light-Induced Incorporation of Bromodeoxyuridine into Parental DNA of an Excision-Defective Mutant of Escherichia coli.- 42. Distribution of Pyrimidine Dimers During Postreplication Repair in UV-Irradiated Excision-Deficient Cells of Escherichia coli K12.- 43. Experiments on the Filling of Daughter-Strand Gaps During Post- replication Repair.- 44. Postreplication Repair Gap Filling in an Escherichia coli Strain Deficient in dnaB Gene Product.- 45. Involvement of uvrD, exrA, and recB Genes in the Control of the Postreplicational Repair Process.- 46. Replication and Expression of Constructed Plasmid Chimeras in Transformed Escherichia coli-A Review.- VI. Relationships Among Repair, Mutagenesis, and Survival.- 47. Relationships Among Repair, Mutagenesis, and Survival: Overview.- 48. SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which Is Accompanied by Mutagenesis.- 49. Thermal Enhancement of Ultraviolet Mutability in a dnaB uvrA Derivative of Escherichia coli B/r: Evidence for Inducible Error-Prone Repair.- 50. lexB: A New Gene Governing Radiation Sensitivity and Lysogenic Induction in Escherichia coli K12.- 51. Indirect Suppression of Radiation Sensitivity of a recA? Strain of Escherichia coli K12.- 52. The Two-Lesion Hypothesis for UV-Induced Mutation in Relation to Recovery of Capacity for DNA Replication.- 53. The Effect of Genes Controlling Radiation Sensitivity on Chemical Mutagenesis in Yeast.- 54. Influence of Repair on the Specificity of Ultraviolet-Induced Reversion of an Ochre Allele of the Structural Gene for Iso- 1-cytochrome c.- 55. The Role of DNA Polymerase I in Genetic Recombination and Viability of Escherichia coli.- 56. The Role of the rec Genes in the Viability of Escherichia coliK12.- Author Index (to Parts A and B).- Subject Index (to Parts A and B).

巻冊次

Part B ISBN 9780306365942

目次

VII. Repair Models and Mechanisms.- 57. Repair Models and Mechanisms: Overview.- 58. List of Genes Affecting DNA Metabolism in Escherichia coli.- 59. Effect of Mutations in lig and polA on UV-Induced Strand Cutting in a uvrC Strain of Escherichia coli.- 60. Dependence Upon Growth Medium and the polA, polC, recA, recB, recC, and exrA Genes of Separate Branches of the uvr Gene-Dependent Excision-Repair Process in Escherichia coli K12 Cells.- 61. Near-UV Photoproduct(s) of L-Tryptophan: An Inhibitor of Medium-Dependent Repair of X-Ray-Induced Single-Strand Breaks in DNA Which Also Inhibits Replication-Gap Closure in Escherichia coli DNA.- 62. The Radiobiology of DNA Strand Breakage.- 63. Radiation-Induced Strand Breakage in DNA.- 64. DNA Repair in DNA-Polymerase-Deficient Mutants of Escherichia coli.- 65. Phleomycin-Induced DNA Lesions and Their Repair in Escherichia coli K12.- 66. Repair of Cross-Linked DNA in Escherichia coli.- 67. Recovery of the Priming Activity of DNA in X-Irradiated Escherichia coli.- VIII. Repair Processes in Diverse Systems.- 68. Repair Processes in Diverse Systems: Overview.- 69. Repair of Double-Strand Breaks in Micro coccus radiodurans.- 70. DNA Repair and Its Relation to Recombination-Deficient and Other Mutations in Bacillus subtilis.- 71. Repair of Ultraviolet Damage in Haemophilus influenzae DNA.- 72. Molecular Mechanisms for DNA Repair in the Blue-Green Algae.- 73. DNA Repair and the Genetic Control of Radiosensitivity in Yeast.- 74. Radiation-Sensitive Mutants of Yeast.- 75. X-Ray-Induced Dominant Lethality and Chromosome Breakage and Repair in a Radiosensitive Strain of Yeast.- 76. The Repair of Double-Strand Breaks in Chromosomal DNA of Yeast.- 77. The Fate of UV-Induced Pyrimidine Dimers in the Nuclear and Mitochondrial DNAs of Saccharomyces cerevisiae on Various Postirradiation Treatments and Its Influence on Survival and Cytoplasmic "Petite" Induction.- 78. Genetic Control of Radiation Sensitivity and DNA Repair in Neurospora.- 79. Enzymes of Neurospora crassa Which Attack UV-Irradiated DNA.- 80. Dictyostelium discoideum: A Valuable Eukaryotic System for Repair Studies.- 81. Absence of Pyrimidine Dimer Excision and Repair Replication in Chlamydomonas reinhardti.- 82. Absence of a Pyrimidine Dimer Repair Mechanism for Mitochondrial DNA in Mouse and Human Cells.- IX. Repair in Mammalian Cells.- 83. Repair in Mammalian Cells: Overview.- 84. Repair (or Recovery) Effects in Quiescent Chinese Hamster Cells: An Attempt at Classification.- 85. Excision-Repair in Primary Cultures of Mouse Embryo Cells and Its Decline in Progressive Passages and Established Cell Lines.- 86. Repair of Alkylated DNA in Mammalian Cells.- 87. Postreplication Repair-of DNA in UV-Irradiated Mammalian Cells.- 88. Synthesis by UV-Irradiated Human Cells of Normal-Sized DNA at Long Times After Irradiation.- 89. Effects of Caffeine on Postreplication Repair in Xeroderma Pigmentosum Cells.- 90. Inhibition of DNA Synthesis by Ultraviolet Light.- 91. Concerning Pyrimidine Dimers as "Blocks" to DNA Replication in Bacteria and Mammalian Cells.- 92. Postreplication Repair in Human Cells:. On the Presence of Gaps Opposite Dimers and Recombination.- 93. Thymine Dimer Excision by Extracts of Human Cells.- 94. Studies on DNA Repair in Mammalian Cells: An Endonuclease Which Recognizes Lesions in DNA.- 95. Formation and Rejoining of DNA Strand Breaks in X (?)-Irradiated Cells in Relation to the Structure of Mammalian Chromatin.- 96. CHO Cell Repair of Single-Strand and Double-Strand DNA Breaks Induced by ?- and ?-Radiations.- 97. The Repair of DNA Double-Strand Breaks in Mammalian Cells and the Organization of the DNA in Their Chromosomes.- 98. Kinetics of the Single-Strand Repair Mechanism in Mammalian Cells.- 99. Damage-Repair Studies of the DNA from X-Irradiated Chinese Hamster Cells.- 100. Current Knowledge of the Formation and Repair of DNA Double-Strand Breaks.- 101. The Dependence of DNA Sedimentation on Centrifuge Speed.- X. Relationships Among Repair, Cancer, and Genetic Deficiency.- 102. Relationships Among Repair, Cancer, and Genetic Deficiency: Overview.- 103. Direct Evidence That Pyrimidine Dimers in DNA Result in Neoplastic Transformation.- 104. Genetic Complementation Analysis of Xeroderma Pigmentosum.- 105. Repair Deficiency and Genetic Complementarity of Fibroblast Cells in Culture from Six Xeroderma Pigmentosum Patients.- 106. Use of an Enzymatic Assay to Evaluate UV-Induced DNA Repair in Human and Embryonic Chick Fibroblasts and Multinucleate Heterokaryons Derived from Both.- 107. The Use of Human Adenovirus 2 in the Study of Xeroderma DNA-Repair Defect.- 108. Host-Cell Reactivation of Irradiated Human Adenovirus.- 109. Animal Viruses, Radiation, Repair Mechanisms, and Cancer.- 110. Excision-Repair of 4-Nitroquinoline-1-oxide Damage Responsible for Killing, Mutation, and Cancer.- 111. Response to Homozygous and Heterozygous Xeroderma Pigmentosum Cells to Several Chemical and Viral Carcinogens.- 112. Cytotoxic and Mutagenic Effects of Carcinogenic Aromatic Amides and Polycyclic Hydrocarbons and Ultraviolet Irradiation in Normally Repairing and Repair-Deficient (Xeroderma Pigmentosum) Diploid Human Skin Fibroblasts.- 113. Lack of Direct Correlation Among Repair, Oncogenesis, and Lethality in Cultured Synchronized Mouse Fibroblasts Treated with N-Methyl-N?-nitro-N-nitrosoguanidine.- 114. Repair of DNA Strand Breaks in Progeric Fibroblasts and Aging Human Diploid Cells.- 115. DNA Repair and Life Span of Mammals.- 116. Increased DNA Excision-Repair as Pathogenesis of a Human Leukemia.- 117. Radiosensitization of a Human Cell Line Lacking Repair Replication.- 118. A Repressible DNA-Repair System in Mouse Neuroblastoma Cells.- 119. DNA Repair and UV Resistance in Human Melanoma.- 120. Faulty DNA Repair Following Ultraviolet Irradiation in Fanconi's Anemia.- Author Index (to Parts A and B).- Subject Index (to Parts A and B).

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詳細情報

• NII書誌ID(NCID): BA07108825
• ISBN:
  • 0306365936
  • 0306365944
• LCCN: 75017731
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: 2 v.
• 大きさ: 24 cm
• 分類:
  • LCC : QP624
  • DC : 574.8/732
• 件名:
  • LCSH : DNA repair -- Congresses
• 親書誌ID:
  • BA00313622