Cellular and molecular events in spermiogenesis : scientific basis of fertility regulation : proceedings of a symposium held at Oaxtepec, Mexico, 11-13 March 1987

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Bibliographic Information

Cellular and molecular events in spermiogenesis : scientific basis of fertility regulation : proceedings of a symposium held at Oaxtepec, Mexico, 11-13 March 1987

edited by D.W. Hamilton, G.M.H. Waites

Cambridge University Press, 1990, c1989

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Proceedings of a symposium sponsored by the WHO Special Programme of Research, Development, and Research Training in Human Reproduction and Family Health International

"Published on behalf of the World Health Organization."

Includews bibliographies and index

Description and Table of Contents

Description

Despite considerable research over the past several decades, there is at present no systemic method of male contraception that is safe, highly effective and reversible. Numerous classes of compounds have been examined, but only a very few have reached the stage of clinical testing. While hormonal regulation of male fertility with the use of steroids or LHRH analogues, or both, has achieved some degree of success in limited clinical trials, its widespread applicability still depends upon considerable development. Clearly, a totally novel approach to finding ways to control male fertility is needed. Thus, it was considered important to bring together experts from various fields to discuss the latest findings in cellular and molecular biology in relation to the regulatory mechanisms of mammalian spermiogenesis. This book records the proceedings of a symposium co-sponsored by the WHO special programme of research, development and research training in human reproduction and family health international held in Oaxtepec, Mexico. This interdisciplinary approach provides new insights and may lay the foundation for the development of a modern male contraceptive for use throughout the world. The book will therefore be of interest to biomedical scientists interested in cell and molecular biology, pharmacology and drug development.

Table of Contents

  • Preface
  • Part I. Introduction and Overview: 1. Spermiogenesis: an introduction to the symposium D. W. Hamilton
  • Part II. The Golgi Apparatus, Lysosomes and Acrosome Formation: 2. Structural and cytochemical characteristics of the Golgi apparatus during the formation of the acrosomic system in rat spermatids Y. Clermont, L. Hermo, A. Rambourg and G. Thorne-Tjomsland
  • 3. Golgi complex: integrity, composition, genesis and homeostasis A. M. Tartakoff
  • 4. Lysosomal enzymes and the Golgi apparatus A. Hasilik and K. Von Figura
  • 5. Pharmacological intervention in Golgi function in MDCK cells J. M. Edwardson, P. U. Daniels and C. Y. Nadin
  • 6. The targeting of proteins of specific cell membrances A. P. Boulton
  • Part III. Centriole and Flagella Formation: 7. The mammalian sperm flagellum: structure and development D. M. Phillips
  • 8. Centrioles, the cell cycle and microtubule formation R. Kuriyama and C. Sellitto
  • 9. Interactions of drugs with microtubules L. Wilson
  • 10. Tektin filaments in the structure and assembly of sperm flagellar microtubules R. W. Linck and M. J. Goggin
  • 11. Synthesis and assembly of flagellar proteins during flagellar regeneration in Chlamydomonas J. L. Rosenbaum
  • Part IV: Cellular and Molecular Events in Spermiogenesis: 12. Cell interactions in the seminiferous tubule: an overview of the roles of Sertoli cell-peritubular cell interactions in testicular functions I. B. Fritz and P. S. Tung
  • 13. Energy metabolism of spermatids: a review J. A. Grootegoed and P. J. den Boer
  • 14. Mammalian spermiogenesis: assembly and fate of perinuclear theca constituents A. Bellve, K. H. Thomas, R. Chandrika, T. M. Wilkie and M. I. Simon
  • 15. Expression of the c-abl oncogene in mouse spermatids D. Meijer, M. von Lindern, T. van Agthoven, G. Grosveld, D. Talarico, G. Dellavalle, P. MacKenbach and J. A. Grootegoed
  • 16. The chromatoid body in early spermatids: its dependence on haploid gene expression and cytoplasmic microtubules M. Parvinen and P. Mali
  • 17. Gene expression during spermiogenesis N. B. Hecht
  • 18. Male contraception and chemotherapy for trypanosomiasis and leishmaniasis: an analysis of biochemical similarities and considerations for future research R. Docampo
  • 19. New approaches to male fertility regulation: interference with spermiogenesis M. Chulavatnatol
  • Part V. Strategies For Research: List of invited participants
  • Index.

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