Computational molecular biology : sources and methods for sequence analysis

著者

書誌事項

Computational molecular biology : sources and methods for sequence analysis

edited by Arthur M. Lesk

Oxford University Press, 1988

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注記

"Prepared under the auspices of CODATA Task Group on Coordination of Protein Sequence Data Banks."

Bibliography: p. [229]-247

Includes index

内容説明・目次

内容説明

This work presents an overview of the field of computing with protein and nucleic acid sequences. It attempts to provide information on what data is available, what calculations can be performed, how to gain access to the data and to necessary programs and how the results of calculations can be interpreted. The book is aimed at investigators determining sequences, to those who analyze them to identify unknown proteins and interpret their function and to those interested in the three-dimensional structures of biological molecules. The work was written in response to an initiative from a CODATA Task Group and aims to bring together information of importance to a wide range of scientists who would otherwise have difficulty finding sources.

目次

  • Part 1 Introduction: an overview of computing with DNA and protein sequences. Part 2 Sources of information: databanks of protein sequences - the National Biomedical Research Foundation (NBRF) protein sequence database, peptide and protein databanks in Japan, additional protein sequence databanks
  • databanks of nucleic acid sequences - GenBank, the EMBL data library
  • databanks of three-dimensional structures - the protein databank. Part 3 Program systems: computer access to sequence databanks
  • the Protein Identification Resource (PIR) software
  • program systems for minicomputers. Part 4 The technical background: gels to sequences
  • computers in modern science
  • an introduction to computer networks. Part 5 Scientific applications: sequence comparison and alignment - the measurement and interpretation of sequence similarity
  • analysis of DNA sequence data
  • prediction of secondary structure of proteins
  • hydrophobicity profiles
  • molecular evolution
  • conclusion - what shall one do with a newly-determined sequence. Part 6 Prospects: the future of computational molecular biology.

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