Design of enzyme inhibitors as drugs
著者
書誌事項
Design of enzyme inhibitors as drugs
Oxford University Press, 1989
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注記
Includes bibliographies and index
内容説明・目次
内容説明
A collection of essays, based on research exploring ways in which the inhibition of the action of particular enzymes in the body can produce a desired therapeutic effect. The book contains accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using the many sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors which are either in clinical use or are under study, emphasizing the factors which affect their usefulness in the clinical context - bioavailability, pharmaco kinetics and side-effects.
目次
- Introduction to the use of enzyme inhibitors as drugs
- general approaches to the design of inhibitors
- inhibitors of the Renin-Angiotens in system enzymes
- lactamase inhibitors
- enkephalinase inhibitors as drugs
- monoamine oxidase inhibitors
- polyamine oxidase inhibitors
- new developments in enzyme activated irreversible inhibitors of pyridoxal phosphate-dependent enzymes of therapeutic interest
- cholinesterase and esterase inhibitors and reactivators of organophosphorus-inhibited esterases
- inhibitors of enzymes of the arachidonic acid metabolic pathways
- selective inhibitors of dihydrofolate reductases
- the antibacterial sulphonamides
- inhibitors of enzymes of the de novo pyrimidine pathway
- inhibitors of purine biosynthesis
- inhibitors of Na+, K+ ATpase
- inhibitors of steriod biosynthesis
- inhibitions of enzymes involved in bacterial cell wall synthesis
- inhibition of proteinases
- development of selective inhibitors of calmodulin-dependent phosphodiesterase and adenylate cyclase
- inhibitors of carbonic anhydrase
- inhibition of intracellular methyl transfer and aminopropyl transfer reactions by analogues of substrates, products, and transition states
- inhibitors of some other target enzymes as potential clinical agents. Index.
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