Oligodeoxynucleotides : antisense inhibitors of gene expression

書誌事項

Oligodeoxynucleotides : antisense inhibitors of gene expression

edited by Jack S. Cohen

(Topics in molecular and structural biology, v. 12)

Macmillan Press, 1989

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注記

Includes bibliographical references nd index

内容説明・目次

内容説明

The recent work on the natural occurrence of antisense RNA and subsequent use of antisense constructs to manipulate gene expression has been of enormous value to molecular biologists and it provides the bulwark behind the endeavours discussed in this publication of the state of the field.

目次

  • Strategies and realities, J.S.Cohen
  • synthesis of oligonucleotides and oligonucleotide analogues, M.H.Caruthers
  • oligodeoxynucleotides covalently linked to intercalating and reactive substances - synthesis, characterization and physicochemical studies, Nguyen Thanh Thuong et al
  • inhibition of gene expression by oligonucleotides, J.Goodchild
  • non-ionic antisense oligonucleotides, P.S.Miller
  • phosphorothioate oligodeoxynucleotide analogues, C.A.Stein and J.S.Cohen
  • oligodeoxynucleotide analogues, B.Rayner et al
  • control of gene expression by oligodeoxynucleotides covalently linked to intercalating agents and nucleic acid-cleaving reagents, C.Helene and J.J.Toulme
  • oligonucleotides linked to reactive groups, D.G.Knorre et al
  • oligonucleotide recognition of double helical DNA by triple helix formation, P.B.Dervan
  • antisense oligodeoxynucleotides as a tool for studying cell regulation - mechanisms of uptake and application to the study of oncogene function, L.M.Neckers
  • pharmaceutical considerations, G.Zon.

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