Intracellular calcium-dependent proteolysis

著者

書誌事項

Intracellular calcium-dependent proteolysis

editors, Ronald L. Mellgren, Takashi Murachi

CRC Press, c1990

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains, which are intracellular, non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed, including their potential roles in muscle protein turnover, platelet activation, membrane fusion, and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

目次

Structural and Regulatory Properties of the Calpains and Calpastatins: Historical Background and Current Status of the Ca 2+ Dependent Proteinase System (D.E. Goll, W.C. Kleese, A. Okitani, T. Kumamoto, J. Cong, and H.-P. Kapprell). The Structures of Calpains and the Calpain Gene (K. Suzuki). Structure-Function Relationships of Calpastatins (M. Maki, M. Hatanaka, E. Takano, and T. Murachi). Calpain Substrate Specificity (K. Takahashi). Protein and Peptide Inhibitors of Calpains (C. Crawford). Subunit Autolysis and Regulation of Calpain II Activity (D.R. Hathaway and P. McClelland). Regulation of Calcium-Dependent Protease Activity In Vitro (D.E. Croall and G.N. DeMartino). The Regulation of Calpains by Interaction with Calpastatins (R.L. Mellgren and R.D. Lane). Calcium-Dependent Proteinases and Their Inhibitor in Drosophila (P. Friedrich and M. Pinter). Calcium-Dependent Proteinases in Crustaceans (D.L. Mykles and D.M. Skinner). Function of the Calcium-Dependent Proteolytic System in Normal Physiology and Pathophysiology: Introduction: Physiological Significance of the Calcium-Calpastatin System (T. Murachi). The Calpain-Calpastatin System and Membrane Fusion (N.S. Kosower and T. Glaser). Calpains and Regulation of Protein Kinase C (K. Hashimoto, K. Mikawa, T. Kuroda, K. Ase, and A. Kishimoto). Calpains and the Cytoskeleton (R.L. Shoeman and P. Traub). Calpains and Hemostasis (R.W. Colman and I. Hoffman). Erythrocyte Calpain in Health and Disease (S. Pontremoli and E. Melloni). The Degradation of Neurofilaments by Calpains (W.W. Schlaepfer and U.-J.P. Zimmerman). Plasticity to Pathology: Brain Calpains as Modifiers of Synaptic Structure (P. Seubert and G. Lynch). Calpains in Lens and Cataract (T.R. Shearer and L.L. David). Index.

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