Cholinergic neurotransmission : functional and clinical aspects : proceedings of Nobel Symposium 76
著者
書誌事項
Cholinergic neurotransmission : functional and clinical aspects : proceedings of Nobel Symposium 76
(Progress in brain research, v. 84)
Elsevier , Sole distributors for the USA and Canada, Elsevier Science Pub. Co., 1990
大学図書館所蔵 全26件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references
Includes index
内容説明・目次
内容説明
This international forum, sponsored by the Nobel Foundation, focussed exclusively on cholinergic mechanisms and was inspired by the first meeting of its kind, organized by Professor Edith Heilbronn and her associates some 20 years ago. The Symposium `Cholinergic Neurotransmission: Functional and Clinical Aspects' took place on the Lidingo Island, Stockholm, in August 1989 and the resulting volume encompasses the contributions of a number of invited scientists prominent in the field of cholinergic neuroscience. The main objective was to provide a detailed overview of the cholinergic research-front of today with emphasis on the basic principles indicating the way to clinical applications. The chapters are organized in such a way as to guide the reader from molecular biology through basic cholinergic pharmacology into clinically oriented contributions that bear upon the number of diseases in which altered cholinergic function is pathophysiologically important, e.g. myasthenia gravis and myasthenic syndromes, disorders of movement and dementia as well as cholinergic mechanisms involved in the regulation of pain, mood and sleep.
目次
Content: I. Molecules and principles in cholinergic synaptology . 1. Molecular biology of choline acetyltranferase J. Mallet. 2. Structure and function of muscarinic receptors M.I. Schimerlik. 3. Multiple pathways for signal transduction through the muscarinic cholinergic receptor J.H. Brown, I. Trilivas, J. Trejo and E. Martinson. 4. Second-messenger responses associated with stimulation of neuronal muscarinic receptors expressed by a human neuroblastoma SH-SY5Y D.G. Lambert and S.R. Nahorski. 5. Function of nicotinic synapses D. Colquhoun, A.B. Cachelin, C.G. Marshall, A. Mathie and D.C. Ogden. 6. Expression and in vivo amplification of the human acetylcholinesterase and butyrylcholinesterase genes H. Soreq and H. Zakut. II. Cholinergic mechanisms in the peripheral nervous system. A. A neuromuscular transmission . 7. Spontaneous synaptic activity at developing neuromuscular junctions N. Tabti and M. Poo. 8. The basal lamina and stability of the mammalian neuromuscular junction C.R. Slater. 9. Functional morphology of the nerve terminal at the frog neuromuscular junction: recent insights using immunocytochemistry F. Torri Tarelli, F. Valtorta, A. Villa and J. Meldolesi. 10. Functional aspects on quantal and non-quantal release of acetylcholine at the neuromuscular junction S. Thesleff. 11. Mediatophore: a nerve terminal membrane protein supporting the final step of the acetylcholine release process M. Israel and N. Morel. 12. Cell surface ATP(P2y)-purinoceptors trigger and modulate multiple calcium fluxes in skeletal muscle cells J. Haggblad, H. Eriksson and E. Heilbronn. 13. Immunogenetic mechanisms in myasthenia gravis L. Steinman. 14. Newly recognized congenital myasthenic syndromes: I Congenital paucity of synaptic vesicles and reduced quantal release. II High-conductance fast-channel syndrome. III Abnormal acetylcholine receptor (AChR) interaction with acetylcholine. IV AChR deficiency and short channel open-time. A.G. Engel, T.J. Walls, A. Nagel and O. Uchitel. 15. Clinical pharmacokinetics of acetylcholinesterase inhibitors P. Hartvig, L. Wiklund, S.M. Aquilonius and B. Lindstrom. 16. Synaptic adaption in diseases of the neuromuscular junction P.C. Molenaar. 17. Current treatment of myasthenia gravis P.O. Osterman. 18. Current therapy of the Lambert-Eaton myathenic syndrome H. Lundh, O. Nilsson and I. Rosen. 19. Future prospects of cholinergic research on neuromuscular transmission S. Thesleff, E. Heilbronn, A.G. Engel and P.C. Molenaar. B. Autonomic nervous system . 20. Structural and functional aspects of acetylcholine peptide coexistence in the autonomic nervous system B. Lindh and T. Hokfelt. 21. The impact of muscarinic receptor subtypes on drug development H. Ladinsky. 22. Basic and clinical aspects on cholinergic agents in bladder dysfunction K.-E. Andersson and H. Hedlund. 23. Cholinergic regulation of the endocrine pancreas B. Ahren, S. Karlsson and S. Lindskog. 24.
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