Coronary circulation in physiological and pathophysiological states

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Coronary circulation in physiological and pathophysiological states

M. Nakamura, P.M. Vanhoutte (eds.)

Springer-Verlag, c1991

  • : jp
  • : gw
  • : us

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Contains the proceedings of the International Symposium on the Coronary Circulation in Physiological and Pathological States, held March 30, 1990 in Fukuoka, Japan, as a satellite symposium to the 54th Annual Meeting of the Japanese Circulation Society

Includes bibliographical references and index

内容説明・目次

巻冊次

: us ISBN 9783540700531

内容説明

The primary problem facing heart specialists continues to be the so-called heart attack - unstable angina, ischemic sudden death and acute myocardial infarction. The mechanisms involved in these events remain poorly understood despite extensive advancements in various therapeutic approaches. This book makes clear what is known and what is not known about coronary circulation. It shows how the regulatory mechanisms, particularly the vasomotor tone, play a role in the pathogenesis of ischemic heart disease. Specific topics are animal models of coronary spasm in the presence of experimental coronary atherosclerosis, endothelium-derived vasoactive factors (EDRF, EDCR) and their modifications by low density lipoproteins, atherosclerotic arterial walls and platelets, the electrophysiology of coronary vascular smooth muscle cells, and the nueral regulation of coronary circulation in the conscious state. It explains new aspects of coronary circulation, such as the laser doppler velocimeter technique which elucidates control mechanisms of coronary flow and a cell biology approach which elucidates angiogenesis in collateral development. This book of proceedings on cardiology and physiology is intended for researchers and clinicians.
巻冊次

: jp ISBN 9784431700531

内容説明

MOTOOMI NAKAMURA As we approach the 21st century, ischemic heart disease is the major cause of death in most of the developed nations of the world. Since the 1970s, much effort and expense have led to designs of coronary thrombolytic therapy, percutaneous coronary angioplasty (PTCA), coronary artery bypass grafting, heart transplantation, automatic defibrillators, as well as to the formation of beta blockers and com pounds which block the calcium channel. Socio-educational programs directed at exercise, diet, instruction in the risk factors of smoking, hyperlipidemia and hypertension have contributed to the decrease in the rate of morbidity and mortality of patients with ischemic heart disease. However, the first clinical event of ischemic heart disease, the so-called "heart attack" and sudden cardiac death continues to present problems, as the mechanisms involved in these events are poorly understood. It has long been thought that ischemic heart disease is the sequence of an organic fixed atherosclerotic obstruction of the epicardial coronary arteries and the role of coronary vasomotion has been given much less attention. Recent clinical and laboratory animal studies revealed that increased tonus and spasm of the large epicardial coronary arteries are the cause of various stages of ischemic heart disease. The role of coronary vasospasm in the development of un stable angina, sudden cardiac death and acute myocardial infarction remains open to debate. Pharmacophysiological studies showed that the epicardial large coronary artery contributes only 5% to regulation of normal coronary flow."

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