Frontiers of Alzheimer research : proceedings of the 5th International Symposium of the Psychiatric Research Institute of Tokyo (PRIT), Tokyo, 10-12 September 1990
著者
書誌事項
Frontiers of Alzheimer research : proceedings of the 5th International Symposium of the Psychiatric Research Institute of Tokyo (PRIT), Tokyo, 10-12 September 1990
（International congress series, no. 946）
Excerpta Medica, 1991
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注記
Organized as a satellite symposium of the XIth International Congress of Neuropathology in Kyoto, Japan
Includes bibliographical references and indexes
Sole distributors for the USA and Canada, Elsevier Science Pub. Co.
内容説明・目次
内容説明
These proceedings focus particularly on topical areas such as the biochemistry, immunohistochemistry, and molecular pathology of amyloid deposition in the brain; the proteolytic enzymes involved in this process, and the possible role of growth factors and immune mechanisms in the pathogenesis of Alzheimer's disease. Many new and exciting findings are presented, and the book truly represents the current "Frontiers of Alzheimer Research". The volume is a valuable source of information for established researchers, and an inspiration to others to become involved in this fast-moving and exciting field.
目次
Epidemiology, symptomatology and differential diagnosis of Alzheimer's disease. What is Alzheimer's disease. Epidemiological study on age-associated dementia. Heterogeneity in Alzheimer's disease. Epidemiological, psychological and psychosocial aspects of senile dementia: On the basis of longitudinal surveys for three years in Japan. Regional cerebral blood flow in primary degenerative dementia: Clinical subgroups and SPECT patterns. Cytoskeletal protein abnormalities as markers of Alzheimer's disease. Pathology of the AD brain. Deposition of beta-amyloid protein along neuronal plasma membranes in diffuse senile plaques and "plaque A". The pathology of amyloid deposition: Cause or effect in Alzheimer's disease. B-protein and tau immunohistochemistry on brains of normal aging and dementia. Ultrastructural morphology and immunocytochemistry on brains of normal aging and dementia. Ultrastructural morphology and immunocytochemistry of beta amyloid classical, primitive and diffuse plaques. Distribution and density of various types of amyloid deposits in cerebral cortex of Alzheimer-type dementia patients and non-demented subjects. Neurofibrillary changes confined to the entorhinal region in cases of presenile and senile dementia. Growth factors and AD brain. Lysosomal proteolysis in Alzheimer brain: Possible roles in neuronal cell death and amyloid formation. Loss of growth-inhibitory factors in Alzheimer's disease brain. Amyloid in AD - Recent advances in pathogenesis, biochemistry and molecular biology. Localization of amyloid beta/A4 protein precursor in the Alzheimer brains. Hereditary cerebral hemorrhage with amyloidosis and Alzheimer's disease. Studies on the binding and proteolytic cleavage of an Alzheimer amyloid beta/A4 synthetic peptide. Deposition of the amyloid beta-protein as a seminal pathogenetic event in Alzheimer's disease. Amyloid precursor protein (APP) mRNA: An update on differential APP transcript abundance in relation to regional neuropathology in Alzheimer's disease. Quantitative analysis of beta amyloid protein precursor derivatives in Alzheimer's disease and control cerebrospinal fluid. A DNA-transfected cell model for Alzheimer amyloidogenesis: Demonstration of primordial amyloid fibrils in COS cells. Role of immune mechanism in the pathogenesis of AD. Characteristics of immune cells in Alzheimer disease brain. Neuroimmune mechanisms of Alzheimer's disease pathogenesis. The role of MHC Class II-positive cells in Alzheimer's disease brain. Neuroimmunological mechanisms in cerebral amyloid deposition in Alzheimer's disease. Neurotransmitter and peptide abnormalities and therapeutic strategies in AD. Qualitative changes of neurotransmitters in Alzheimer's disease. Neuropeptide abnormalities in Alzheimer-type dementia brains. Index of Authors.
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