CiNii 図書 - Occupational toxicants : critical data evaluation for MAK values and classification of carcinogens

The Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area was called into being by the German Science Foundation in 1955. Its mandate was to continue the development begun by German toxicologists in the last century and to establish a scientific basis for the protection of workers from the adverse effects of toxic chemicals, making recommendations for the establishment of "MAK" values (maximimum concentrations at the workplace) and the classification of carcinogenic substances. Since then the scope of the Commission's activities has been extended, and its recommendations are published annually in the form of evaluation documents. The present volume is the first in a series of English translations of these evaluation documents, including a selection of the Commission's work in the establishment of "MAK" values in the last two years.

Part 1 General papers: carcinogenic medicines
germ cell mutagens
limitation of exposure peaks
nitrosation of volatile amines at the workplace
passive smoking at work. Part 2 Single substances, substance classes and complex mixtures: 1-chloro-1,1-diffluoroethane
chlorotrifluoromethane
1,2-dichlorobenzene
1,3-dichlorobenzene
1,2-dichloromethoxyethane
1,3-dichloro-2-propanol
diesel engine emissions
dimethyl ether
dimethyl hydrogen phosphite
dimethylsulfamoyl chloride
dinitrobenzene (all isomers)
hydrazine
limonene
2-methoxy-1-propanol
2-methoxypropyl-1-acetate
n-methylene-bis(2-chloroethyl)amine
methyl2-cyanoacrylate and ethyl 2-cyanoacrylate
4,4'-methylene-bis(n,n-dimethylaniline)
4-nitrobiphenyl
n-nitrosamines
perchloromethylmercaptan
1,1,2,2-tetrachloro-1,2-difluoroethane
thiourea
tri-n-butyltin compounds
trichlorofluoromethane
2,2,4-trimethylpentane
2,4,6-trinitrotoluene
4-vinyl-1,2-cyclohexenediepoxide.

English translation of the "Toxikolisch-arbeitmedizinischen Begrundungen von MAK Werten", showing which observations, experience and considerations determined the established MAK value. The text is intended for toxicologists, environmental chemists, food chemists and ecologists.

Part 1 Dusts: general threshold limit value for dust
dust definitions and guidelines
fumes definitions and guidelines
aluminium
asbestos
calcium sulphate
graphite
iron oxides
magnesium oxide
polyvinyl chloride
silica, amorphous
talc (without asbestos fibres)
titanium dioxide. Part 2 Metal-working fluid components: list of metal-working fluid components
1,2 benzisothiazol-3(2H)-one
1H-benzotriazole
benzyl alcohol mono(poly)hemiformal
bromo-2-nitro-1,3-propanediol
p-chloro-m-cresol
dibenzyl disulphide
2-hydroxymethyl-2-nitro-1,3-propanediol
methyl-1H-benzotriazole
o-phenylphenol and sodium o-phenylphenol
tetrahydrobenzotriazole
triphenyl phosphate
N,N',N"-tris(beta-hydroxyethyl)-hexahydro-1,3,5-triazin(THT).

The methods in this book emphasize the work of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area into the specification and justification of maximum permissible concentrations of hazardous substances in the work area. In addition, they represent the methodological spectrum available today for the biological monitoring of occupationally exposed persons.

Acetaldehyde
acrylamide
beryllium and its compounds
o-chloroaniline
m-chloroaniline
p-chloroaniline
chlorodifluoromethan
chloroethane
chloroparaffins
chromium and its compounds
cobalt compounds
3,3'-diaminobenzidine
1,2-dichloroethane
n,n-dimethylaniline
dimethyl sulfoxide
formaldehyde
lithium hydride
methyl methacrylate
nitric acid
2-nitropropane
organic peroxides
pentachlorophenol
tetrachloroethylene
tetraethyl silicate
o-toluidin and o-toluidinehydrochloride
p-toluidine
trichlorobenzene
1,1,2-trichloro-1,2,2-trifluoroethane.

The methods in this book emphasize the work of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area into the specification and justification of maximum permissible concentrations of hazardous substances in the work area. In addition, they represent the methodological spectrum available today for the biological monitoring of occupationally exposed persons.

Amitrol
auramine, auramine base
bis(beta-chloroethyl)sulfide
1,4-butane sultone and 2,4-butane sultone
1-n-butyl glycidyl ether and 1-tert-butyl glycidil ether
epsilon-caprolactam
carbon monoxide
3-chloro-2-methylpropene
o-chloronitrobenzene
m-chloronitrobenzene
p-chloronitrobenzene
p-chloronitrobenzene
p-cresidine
1,4-dichlorobenzene
dichloromethane
2,4-dichlorophenoxyacetic acid
dichlorvos
dimethl sulfate
ethylene glycol
glycidyl trimethylammonium chloride
n-hexane
hexane
maleic anhydride
2-nitro-4-aminophenol
2-nitro-p-phenylenediamine
phenyl glycidil ether
1,3-propane sultone
tetranitromethane
4,4'-thiodianiline
2,4,5-trimethylaniline and its hydrochloride
1,3,5-trimethylbenzene
vanadium pentoxide
wood dust.

Describes the data base which determines the level of a MAK value (maximum concentration value in the workplace) and gives a summary of the relevant international literature. The accumulated expertise of the Commission's toxicologists and occupational physicians makes the reviews not just accounts of the published data but also critical evaluation documents. Each evaluation document includes sections about toxic effects and modes of action, effects in humans, effects on animals, genotoxicity and carcinogenicity, and manifesto.

3-amino-9-ethylcarbazole
n-butyl acrylate
1,2-butylene oxide
cadmium and its compounds
calcium cyanamide
2-chloroethanol
chlorofluoromethane
n-chloroformylmorpholine
alpha-chlorohydrin
3,3'-dichlorobenzidine
dichlorodifluoromethane
dichlorofluoromethane
dicyclopentadiene
1,1-difluoroethylene
3,3'-dimethoxybenzidine
3,3'-dimethylbenzidine
disulfiram
ethylene oxide
alpha-hexachlorocyclohexane and beta-hexachlorocyclohexane
2-isopropoxyethanol
1-methoxy-2-propanol
1-methoxypropyl-2-acetate
1,2-propylene oxide
vinyl acetate
vinyl chloride
n-vinyl-2-pyrrolidone
xylene (all isomers)
metal-working fluid components
1,3-bis(hydroxymethyl)urea
boric acid
5-chloro-2-methyl-2,3-dihydroisothiazol-3-one and 2-methyl-2,3-dihydroisothiazol-3-one
2,6-di-tert-butylphenol
2-ethyl-1,3-hexanediol
hexamethylenetetramine
1-hydroxyethyl-2-heptadecenyl-imidazoline.

This text provides critical data evaluation for MAK values and classification of carcinogens.

Ammonia
Aniline
Bromotrifluoromethane
2-Butoxyethanol
2-Butoxyethyl acetate
Chlordimeform
-Chlorinated Toluenes
Chloropicrin
Chlorothalonil
4-Chloro-o-toluidine and its hydrochloride
5-Chloro-o-toluidine
2,4-Diaminoanisole and 2,4-Diaminoanisole sulfate
Dichloroacetylene
Dinitrotoluenes (mixtures of isomers)
Dipropylene glycol monomethyl ether
2-Ethoxyethanol
2-Ethoxyethyl acetate
Ethyl acrylate
Hydrogen chloride
2-Methoxyethanol
2-Methoxyethyl acetate
Methyl acrylate
N-Methylaniline
5-Nitro-o-toluidine
4,4-Oxydianiline
m-Phenylenediamine
o-Phenylenediamine
p-Phenylenediamine
Toluene-2,4-diamine
Authors of Documents in Volume 6
Index.

This volume provides critical data evaluation for MAK values and classification of carcinogens. Detailed information is given on their toxic effects and modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity.

Acetone
cadmium
chlorinated paraffins
chromium (VI) compounds
dimethylformamide
diethylene glycol monobutyl ether
dimethylamine
di-n-octyltin compounds
ethyl bomide
furfuryl alcohol
gluraraldehyde
isoflurane
methylamine
methyl bromide/chloride/iodide
2-nitrotoluene
peracetic acid
phthalic acid
toluene
phthalic anhydride
tribomomethane. (Part contents).

Dimethylformamide. Glutaraldehyde. 4,4'-Methylene Diphenyl Isocyanate (MDI) and "Polymeric MDI" (PMDI). 2-Nitrotoluene. Vinylidene Chloride. Fibrous Dust. Authors of Documents in Volume 8. Index.

The volumes of this series describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Several important carcinogens are treated separately. Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects on man, effects on animals, genotoxicity and carcinogenicity. Volume 9 contains 29 additional compounds, half of them metal-working fluid components.

Metal-working fluid components: 2-(2-aminoethoxy) ethanol, 1-amino-2-propanol, 2-amino-2-ethyl-1,3-propanediol, decyl oleate, 2-amino-2-methyl-1-propanol, bithionol, 1-hexanol, cloroacetamide-n-methylol, piperazine, triethylene glycol n-butyl ether
chloroacetic acid methyl ester
cholorpromazine
diethylene glycol dimetyl ether
hydrazobenzene
nitrous oxide
olaquindox.

The volumes of this series present almost 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto. Volume 10 contains 16 reviews, 3 of them on metal-working fluid components. From the contents: Ozone, Trichloroethylene, Cyclohexanone, o-Anisidine, 2-Chloroacrylonitrile, p-Chlorobenzotrichloride, Cobalt, Diethylene glycol, Ethylene, Hydroquinone, N-Methyl-2-pyrrolidone, Polyethylene glycol, Polypropylene glycol, Sodium pyrithione.

o-Anisidine. 2-Chloroacrylonitrile. p-Chlorobenzotrichloride. Cobalt, its Alloys and Water-Soluble Salts. Cyclohexanone. 2,2-Dichloro-1,1,1-trifluoroethane. Diethylene Glycol. Ethylene. Hexahydrophthalic Anhydride/Methyltetrahydrophthalic Anhydride. Hydroquinone. N-Methyl-2-pyrrolidone (vapour). Ozone. Trichloroethylene. METAL-WORKING FLUID COMPONENTS. Polyethylene Glycol. Polypropylene Glycol. Sodium Pyrithione. Authors of Documents in Volume 10. Index.

The volumes of this series present more than 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about topics such as toxic effects, modes of action, effects in man, and effects on animals.

Changes in the classification of carcinogenic chemicals in the work area - 2-aminoethanol
2-butanone
n-butyl acrylate
carbon disulfide
chloroacetaldehyde
chlorobenzene
ethanol
ethyl acetate
piperazine
2-propoxyethanol
2-propoxyethyl acetate
sodium hydroxide
2,4,5-trichlorophenol
zirconium and its compounds
dusts - general threshold limit value for dust
aerosols dusts, fumes and mists
manganese and its inorganic compounds.

The volumes of this series present more than 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto. The accumulated expertise of the Commission's toxicologists and occupational physicians makes their reviews invaluable for all involved in occupational health and safety.

GENERAL PAPERS Passive smoking CHEMICAL SUBSTANCES Acetic anhydride Ammonia Bisphenol A Boron oxide Boron trifluorid N--Carboxyanthranilic anhydride Cereal flour dusts rye and wheat Chlorinated naphthalenes 1--Chloro--2,4--dinitrobenzene Cumene Cyclohexane Diazomethane Diethylether Ethylene glycol dimethacrylate Ethylene oxide Hexone Hydrazine Hydrogen bromide 2--Hydroxyethyl methacrylate Methyl 2--cyanoacrylate and Ethyl 2--cyanoacrylate 2--Nitro--p-- phenylenediamine 1--Nitropropane o--Phenylenediamine TEDP 1,1,1,2--Tetrafluoroethane Triethylamine
Woods: Acacia melanoxylon Bowdichia nitida Brya ebenus Dalbergia latifolia, D. melanoxylon, D. nigra, D. retusa, D. stevensonii Machaerium sceloxylon

The volumes of this series present more than 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto. The accumulated expertise of the Commission's toxicologists and occupational physicians makes their reviews invaluable for all involved in occupational health and safety.

GENERAL PAPERS
The Relevance of Physical Activity for Inhalation Kinetics
The Relevance of Hyperbaric Pressure for the Body Burden of Inhaled Gaseous Compounds
CHEMICAL SUBSTANCES
Chloroform
Cresol (all Isomers)
Diborane
1,2-Dibromo-2,4-Dicyanobutane
2-Diethylaminoethanol
n-Hexane
1-Methoxy-2-Propanol
4,4'-Methylene Diphenyl Isocyanate (MDI) and "Polymeric MDI" (PMDI)
4-Nitrosophenol
p-Phenylenediamine
Thiourea
Tin and Its Inorganic Compounds
1,2,4-Trichlorobenzene
Turpentine
Vinylcarbazole
4-Vinylcycohexene
DUSTS
Silica, Crystalline: Quartz Dust, Cristobalite Dust and Tridymite Dust (Respirable Fraction)
WOODS
Calocedrus Decurrens
Chlorophora Excelsa
Diospyros Species
Distemonanthus Benthamianus
Grevillea Robusta
Mansonia Altissima
Panatecoma Peroba
Tabebuia Species
Tectona Grandis
Authors of Documents in Volume 14
Index

The volumes of this series present more than 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.

Acrylic acid polymer (neutralized, cross--linked)
Allyl alcohol
Arsine
1,3--Butadiene
Butynediol
g--Hexachlorocyclohexane (Lindane)
Hexachlorobenzene
Merbromin
Mercury and inorganic mercury compounds
Mercury compounds, organic
Methanol
a--Methyl styrene
Natural rubber latex
Rubber components
Sulfuric acid
Thimerosal
Xylene (all isomers)
Zinc chromate

The volumes of this series present more than 300 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.

Acrolein
n-Butyl acrylate
Ethyl acrylate
2-Ethylhexyl acrylate
Ethyl methacrylate
Glutaraldehyde
Hexachlorobenzene
2-Hydroxyethyl acrylate
Hydroxypropyl acrylate (all isomers)
2-Hydroxypropyl methacrylate
Lindane
Methanol
Methyl acrylate
Methyl methacrylate
Pentaerythritol triacrylate
Trimethylolpropane triacrylate
Metal-working fluid components
Citric acid and its alkali metal salts
5-Ethyl-3,7-dioxa-1-azabicyclo[3.3.0]octane (EDAO)
Hexylene glycol
3-Iodo-2-propynyl-N-butylcarbamate
Isodecyl oleate
2-Octyl-4-isothiazolin-3-one
Oleoyl sarcosine
Dusts
Aerosols - ultrafine aerosol particles, their aggregates and agglomerates
Tantalum
Wollastonite

The volumes of this series present about 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.

General Papers
Germ Cell Mutagens
Chemical Substances
Benzaldehyde
Bitumen (vapour and aerosol)
tert-Butyl methyl ether
Dichloromethane
Formaldehyde
Lead and its inorganic compounds
Oleic acid
Phenyl isocyanate
Picric acid
Tributyl phosphate
Turpentine
Author of Documents in Volume 17
Index

The volumes of this series present about 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.

Allyl chloride. Amitrole. Carbon black in the form of inhalable dust. Carbon tetrachloride. Coal mine dust. Diisobutyl ketone. Endrin. Furfural. Methyl acetate. 4,4'--Methylene--bis(2--methylaniline). Molybdenum and its compounds. Wood dust. Woods: Entandrophragma species. Woods: Gonystylus bancanus (Miq.) Baill. Woods: Khaya species. Woods: Quercus species. Woods: Swietenia species. Woods: Terminalia ivorensis A.Chev., Terminalia superba Engl. & Diels Woods: Thuja species. Woods: Tieghemella Africana A. Chev., Tieghemella heckelii Pierre. Woods: Triplochiton scleroxylon K. Schum. Zinc chloride and zinc chloride fume. Zinc oxide fume.Authors of Documents in Volume 18.Index.

The volumes of this series present about 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity, manifesto.

Acetonitrile. Bisphenol A diglycidyl ether. n--Butyl acetate. sec--Butyl acetate. tert--Butyl acetate. n--Butyl alcohol. sec--Butyl alcohol. tert--Butyl alcohol. Demeton. 4,6--Dinitro--o--cresol. Ferbam. Formic acid. Formic acid ethyl ester. Furfuryl alcohol. Hydrogen cyanide, potassium cyanide and sodium cyanide. Isobutyl acetate. Isobutyl alcohol. Nitrobenzene. Nitroethane. Nitromethane. Rotenone. Strychnine. Toxaphene. Xylidine (isomers). Authors of Documents in Volume 19. Index.

The volumes in this series present some 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database that determines the level of a MAK value (Maximum Concentrations at the Workplace). Each document is written to a standard format and includes sections on toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenicity.

Butane (both isomers). 1,2--Dichlorobenzene. 1,4--Dichlorobenzene. Diethyl sulfate. 1,4--Dioxane. 2--Ethylhexanol. Glycidol. Ketene. Metal working fluids. Mothyl mercaptan. 1 --Octanol. Resorcinol. Sodium azide. Styrene. Toluene diisocyanate. Authors of Documents in Volume. Index.

Occupational toxicants : critical data evaluation for MAK values and classification of carcinogens

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Occupational toxicants : critical data evaluation for MAK values and classification of carcinogens

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大学図書館所蔵件 / 全18件