Oligonucleotides and analogues : a practical approach
著者
書誌事項
Oligonucleotides and analogues : a practical approach
（The practical approach series）
IRL Press : Oxford University Press, c1991
- : pbk
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
: pbk ISBN 9780199632794
内容説明
Interest in oligonucleotide synthesis has expanded dramatically since the publication of Gait's book in this series in 1984. The process has been automated, new reagents have been developed, and the range of uses for the compounds produced has increased and continues to grow. This volume provides practical guidance on oligonucleotide synthesis and methods for introducing modifications into these molecules. State-of-the-art techniques for automated synthesis are
covered in two chapters on the production of oligodeoxynucleotides and oligoribonucleotides. Synthesis of modified oligodeoxynucleotides is also detailed, including modification of the phosphate backbone to produce phosphorothioates, phosphorodithioates and methyl phosphonates, all of which are of
considerable importance due to their potential therapeutic applications. Other chapters describe production of sugar-modified oligodeoxynucleotides and the attachment of various reporter groups; these techniques are useful to those interested in non-radioactive probes for hybridization and for the study of DNA-DNA and DNA-protein interactions.
This book will be of interest to academic and industrial researchers, enabling both chemists and non-chemists to synthesize oligonucleotides and analogues for a wide variety of experimental purposes.
目次
- T. Brown & D.J.S. Brown: Modern machine-aided methods of oligodeoxyribonucleotide synthesis
- M. Gait, C. Prichard & G. Slim: Oligoribonucleotide synthesis
- B. Sproat: 2'-O-methyl oligoribonucleotides
- G. Zon & W.J. Stec: Phosphorothioate oligonucleotides
- P. Miller, C.D. Cushman & J.T. Lewis: Methylphosphonate oligonucleotides
- B. Connolly: Oligonucleotides with modified bases
- N.D. Sinha & S. Streipeke: Oligonucleotides with reporter groups attached to the 5' terminus
- Prof D. McLaughlin et al: Oligodeoxynucleotides with reporter groups attached via the phosphate backbone
- Prof L. McLaughlin et al: Oligonucleotides for affinity chromatography
- J. Ruth: Oligonucleotides with reporter groups attached via the base
- N.T. Thuong & U. Asseline: Oligonucleotides attached to intercalators, photoreactive agents and cleavage agents
- 巻冊次
-
ISBN 9780199632800
内容説明
Interest in oligonucleotide synthesis has expanded dramatically since the publication of M.Gait's book in this series in 1984. The process has been automated, new reagents have been developed, and the range of uses for the compounds produced has increased and continues to grow. This volume provides practical guidance on oligonucleotide synthesis and methods for introducing modifications into these molecules. Techniques for automated synthesis are covered in two chapters on the production of oligodeoxynucleotides and oligoribonucleotides. Synthesis of modified oligodeoxynucleotides is also detailed, including modification of the phosphate backbone to produce phosphorothioates, phosphorodithioates and methyl phosphonates, all of which are of considerable importance due to their potential therapeutic applications. Other chapters describe production of sugar-modified oligodeoxynucleotides and the attachment of various reporter groups; these techniques are useful to those interested in non-radioactive probes for hybridization and for the study of DNA-DNA and DNA-protein interactions.
This book should be of interest to academic and industrial researchers, enabling both chemists and non-chemists to synthesize oligonucleotides and analogues for a wide variety of experimental purposes.
目次
- T. Brown & D.J.S. Brown: Modern machine-aided methods of oligodeoxyribonucleotide synthesis
- M. Gait, C. Prichard & G. Slim: Oligoribonucleotide synthesis
- B. Sproat: 2'-O-methyl oligoribonucleotides
- G. Zon & W.J. Stec: Phosphorothioate oligonucleotides
- P. Miller, C.D. Cushman & J.T. Lewis: Methylphosphonate oligonucleotides
- B. Connolly: Oligonucleotides with modified bases
- N.D. Sinha & S. Streipeke: Oligonucleotides with reporter groups attached to the 5' terminus
- Prof D. McLaughlin et al: Oligodeoxynucleotides with reporter groups attached via the phosphate backbone
- Prof L. McLaughlin et al: Oligonucleotides for affinity chromatography
- J. Ruth: Oligonucleotides with reporter groups attached via the base
- N.T. Thuong & U. Asseline: Oligonucleotides attached to intercalators, photoreactive agents and cleavage agents.
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