Vascular endothelium : interactions with circulating cells
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Bibliographic Information
Vascular endothelium : interactions with circulating cells
（Research monographs in cell and tissue physiology, v. 17）
Elsevier, 1991
- : alk. paper
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Includes bibliographical references and index
Description and Table of Contents
Description
Vascular endothelium is arguably the most important biological interface - that between the blood and the tissues of the body. The role of endothelium as a haemocompatible lining of blood vessels has long been known, however, due to a dramatic expansion of research activity made possible by technical advances, the catalogue of known endothelial activities is now extensive. These cells play an active role in the inflammatory process, the regulation of haemostasis and vascular tone, and the uptake and metabolism of numerous biochemical mediators. The concept of endothelium as little more than a nucleated, haemocompatible biodialysis bag has drastically changed. The main themes of this volume centre around i) the dramatic discovery that endothelium can upregulate adhesive proteins on its surface in response to mediators such as cytokines, and that these adhesins can act as anchors for circulating cells and ii) the extravascular migration of the circulating cells.
Table of Contents
Contents: Preface. List of Contributors. SECTION A: Molecular basis of adhesion. Cloning cell surface molecules using monoclonal antibodies (D.L. Simmons, L. Needham). Endothelial cell integrin receptors (E. Dejana). Direct-expression cloning of endothelial adhesion molecules (L. Osborn, R. Lobb). SECTION B: Cell biology of adhesion and migration. Adhesion of granulocytes, monocytes and related cell lines (L. Needham, J.D. Pearson, P.G. Hellewell). Lymphocyte adhesion in inflammation (M.H. Thornhill, D.O. Haskard). Tumor cell adhesion to the endothelium (D. Lauri, L. Needham, E. Dejana). Endothelium-derived modulators of leukocyte function (A. Mantovani, F. Bussolino). SECTION C: Experimental studies in vivo. Mechanisms of granulocyte accumulation and emigration in vivo (P.G. Hellewell, P.M. Henson). Mechanisms of granulocyte-dependent oedema (S. Nourshargh, T.J. Williams). Desensitisation mechanisms regulating plasma leakage and neutrophil emigration (I.G. Colditz). Monocyte-endothelium interactions and their inhibition (H. Rosen). Endothelium-tumor cell interaction in the metastatic process (R. Giavazzi, G. Taraboletti). SECTION D: Pathology. The kinetics of ELAM-1 and VCAM-1 expression and leukocyte migration in vivo (D.O. Haskard). ELAM-1 expression in human malignancies (L.P. Ruco, A.J.H. Gearing). Consequences of deficient granulocyte-endothelium interactions (B.R.Schwartz, J.M. Harlan). Erythrocyte-endothelial interactions in plasmodium falciparum malaria, sickle cell anaemia and diabetes (A.R. Berendt).
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