Duchenne muscular dystrophy : animal models and genetic manipulation

Bibliographic Information

Duchenne muscular dystrophy : animal models and genetic manipulation

editors, Byron A. Kakulas, John McC. Howell, Allen D. Roses

Raven Press, c1992

Available at  / 3 libraries

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Note

"A record of the proceedings of an international workshop held in the Australian Neuromuscular Research Institute ... from August 7-9, 1991"--P. xii

Includes bibliographical references and index

Description and Table of Contents

Description

This volume assesses research, in humans and in animals, on myoblast transfer and gene therapy for Duchenne muscular dystrophy (DMD). The contributors describe and compare two different animal models used in current experiments on DMD therapy: the xmd dog, which exhibits skeletal muscular dystrophy similar to human DMD, and the mdx mouse, which shares the genetic dystrophin defect underlying the disease, but does not develop severe progressive skeletal myopathy. Noted experts analyze studies on myoblast transfer in DMD patients and animals, explore new strategies for direct gene transfer in DMD, and discuss the relative feasibility of donor myoblast transfer, direct gene transfer, and patient myoblast-mediated gene transfer.

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