Human drug metabolism : from molecular biology to man
Author(s)
Bibliographic Information
Human drug metabolism : from molecular biology to man
（Pharmacology & toxicology）
CRC Press, c1993
- :acid-free paper
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Human Drug Metabolism fills a long-standing gap in the scientific literature on research into drug metabolism in humans. While many books exist on clinical studies, this is the first to wed basic biochemical and molecular biological experiments using human tissue with clinical experiments. Numerous examples of drug metabolism in human tissue (often more meaningful to medical and general health sciences students than animal studies) are presented. Modern techniques used by bench scientists are described for the experimental diagnosis of cancer, toxicity, and genetic susceptibility. A number of different drug metabolizing systems, many focusing on intra-individual variation, are examined. The book also discusses clinically dramatic effects of infection and the host response system on the metabolism of drugs and subsequent toxicity. Human Drug Metabolism is an important reference for pharmacologists, toxicologists, molecular biologists, and biochemists. It will also be useful to medical students and students in general health sciences.
Table of Contents
Introduction (E.H. Jeffery). Human Cytochrome P-450 Enzymes and Chemical Carcinogenesis (F.P. Guengerich and T. Shimada). cDNA-Directed Expression of Human Cytochrome P450 (F.J. Gonzalez and H.V. Gelboin). Human P450 Enzymes Associated with the Mephenytoin 4-Hydroxylation Polymorphism (J.L. Raucy and J.M. Lasker). Assessment of Drug Oxidation in Man In Vivo (D.D. Breimer). Covalent Binding of Acetaminophen Estimated from Protein Adducts (H.E. Poulsen, D.W. Roberts, and J.A. Hinson). Xenobiotic Metabolism Studies with Human Liver (D.E. Chapman, G. Powis, S.R. Michener, and T.A. Christensen). Epoxide Hydrolases: Immunochemical Detection in Human Tissues (T.M. Guenthner, J. Kuk, M. Nguyen, C.W. Wheeler, M. Pirmohamed, and B.K. Park). Conjugation Reactions in Man: Studies with Diflunisal (R.K. Verbeeck). Analysis of the Specificity of Human Lover Glucuronidation Using Cloned and Stably Expressed UDP-Glucuronosyltransferases (B. Burchell, T. Ebner, R. Wooster, and L. Sutherland). Properties of Human Cytosolic Sulfotransferases Involved in Drug Metabolism (C.N. Falany and J.A. Roth). Acetylation Pharmacogenetics (U.A. Meyer, M. Blum, D. Grant, M. Heim, F. Broly, F. Hoffman, M. Probst, J. Garcia-Agundez). Glutathione S-Transferase Localization in Human Tumors (D.J. Harrison). Glutathione Conjugation in Man (T.M.T. Mulders, D.D. Breimer, and G.T. Mulder). Alteration of Drug Biotransformation during the Operation of Host Defense Merchanism in Humans (K.W. Renton).
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