Natural products as antiviral agents
著者
書誌事項
Natural products as antiviral agents
Plenum Press, c1992
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
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  アメリカ
注記
"Proceedings of an American Chemical Society Agricultural and Food Chemistry Division symposium on Natural products as antiviral agents, held August 27, 1991, in New York" --Copr. p
Includes bibliographical references and index
内容説明・目次
内容説明
During the past fifty years, thousands of natural products have been isolated from plants, fungi, and bacteria. Apart from intense searches by pharmaceutical companies for medicinals and the concentrated effort mounted by the National Cancer Institute, many of these have not been tested in biological systems. The major reasons for this appear to be, at least, twofold. First, individual researchers looking for biologically active natural products will often isolate only small amounts of material sufficient to determine a structure and calculate the specific activity for their particular bioassay systems: insufficient funds preclude re-isolating the compound unless industrial potential is foreseen. Second, the difficulty with which original structures were proved prior to 1972. This required the isolation of relatively large quantities of a natural product and there followed extensive degradation, elemental analyses of the parent and its fragments, then synthesis, piece by piece, of the molecule. All this took time and energy. No wonder that when the structure was proved the chemist was enervated. And coupled to this was the fact that many chemists were not trained to test their materials in biological systems. In contrast, today a natural product can be isolated, its mass and molecular formula determined and, if there is some serendipity, crystals may be obtained for single crystal x-ray analysis. If conditions are near perfect, it is possible to isolate and identify a novel compound in a month.
目次
Progress in the Development of Natural Products for Human Immunodeficiency Viruses Infections (R.F Schinazi). StructureActivity Correlations of Natural Products with AntiHIV Activity (M. Nasr et al.). AIDSAntiviral Natural Products Research at the US National Cancer Institute (K.R. Gustafson et al.). Tannins and Related Compounds as AntiHIV Agents (K.H. Lee et al.). Mode of Action of Hypericin as an Antiretroviral Agents and Other Relevant Findings (D. Meruelo et al.). Activity of Selected Amaryllidaceae Constituets and Related Synthetic Substances Against Medically Important RNA Viruses (B. Gabrielsen et al.). Aminosugar Attenuation of HIV Infection (G.S. Jacob et al.) Plant Proteins with Antiviral Activity Against Human Immunodeficiency Virus (S. LeeHuang et al.). Antiviral Studies with Trichosanthin, A Plant Derived Single Chain Ribosome Inactivating Protein (M.S. McGrath et al.). 4 additional articles. Index.
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