Cerebellar degenerations : clinical neurobiology
著者
書誌事項
Cerebellar degenerations : clinical neurobiology
(Foundations of neurology)
Kluwer Academic Publishers, c1992
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in undestanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cer ebellar cellular systems. More than any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotransmitters. Excitatory amino acid transmitters, in addition to serving neuronal com munication, may also mediate trophic and toxic effects, and as such, they may playa role in neurodegenerative processes. The cerebellar degenerations were among the first human disorders with primary system atrophy to be studied clinically and pathologically. This field of clinical cerebellar sciences, no longer confined to the previously known descriptive level, is now advancing rapidly, propelled by rapid advances in neuroimaging, immunology, and molecular biology. The advent of CT, MRI, and PET has in recent years permitted the study of central nervous system alterations in living patients, thus contributing substantially to the accuracy of the diagnosis and the classification of these disorders. The nosology of cerebellar degenerations, which has been the subject of much debate for over a century, is presently a dynamic field, with new entities being recognized and old "classic ataxias" being redefined in the light of new genetic evidence.
目次
- Introduction. 1. The Cerebellum and its Disorders in the Dawn of the Molecular Age
- A. Plaitakis. Part I: Basic Neurosciences of the Cerebellum. 2. Anatomy and Neurochemical Anatomy of the Cerebellum
- J. Hamori. 3. Physiology of the Cerebellum
- M. Ito. 4. Amino Acid Transmitters in the Adult and Developing Cerebellum
- R. Balazs. 5. Glutamate Receptors in Mammalian Cerebellum: Alterations in Human Ataxic Disorders and Cerebellar Mutant Mice
- E. Kouvelas, A. Mitsakos, F. Angelatou, P. Tsiotos, G. Voukelatou. 6. Regional and Cellular Distribution of Glutamate Dehydrogenase and Pyruvate Dehydrogenase Complex in Brain: Implications for Neurodegenerative Disorders
- C. Aoki, T.A. Milner, V.M. Pickel. 7. The Purkinje Cell Degeneration Mutant, A Model to Study the Consequences on Neuronal Degeneration
- B. Ghetti, L. Triarchou. Part II: Clinical Neurosciences of the Cerebellum. 8. Classification and Epidemiology of Cerebellar Degenerations
- A. Plaitakis. 9. The Cerebellar Cortex and the Dentate Nucleus in Hereditary Ataxias
- A.H. Koeppen, D.I. Turok. 10. Clinical Neurophysiology in Olivopontocerebellar Atrophy
- S. Chokroverty. 11. Pathophysiology of Ataxia in Humans
- H.C. Diener, D. Dichgans. 12. Oculomotor Abnormalities in Cerebellar Degeneration
- M. Fetter, J. Dichgans. 13. Clinical and Radiologic Features of Cerebellar Degenerations
- A. Plaitakis, S. Katoh, Y.P. Huang. Part III: Ethiopathogenesis of Cerebellar Disorders. 14. Glutamate Dehydrogenase Deficiency in Cerebellar Degenerations
- A. Plaitakis,P. Shashidharan. 15. Mitochondrial Abnormalities in Hereditary Ataxias
- S. Sorbi, J.P. Blass. 16. Cerebellar Disorders in Hexosaminidase Deficiencies
- W.G. Johnson. 17. Dominant Olivopontocerebellar Atrophy Mapping to Human Chromosome 6p
- M. Nances, L.J. Schut. 18. Positron Emission Tomography of Cerebellar Degeneration
- S. Gilman. 19. Ataxia Telengiectasia. A Human Model of Neuro-Immune Degeneration
- M. Fiorelli, M. Carbonari, M. Cherchi, C. Gaetano. 20. Paraneoplastic Cerebellar Degeneration
- J.E. Hammack, J.B. Posner. Index.
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