The Parathyroids : basic & clinical concepts
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書誌事項
The Parathyroids : basic & clinical concepts
Raven Press, c1994
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
More than 50 chapters examine the anatomy and physiology of the parathyroids; the structure, function, and actions of parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHRP); the causes of management of hypercalcemia due to PTHRP and other factors; and the pathophysiology, diagnosis, and treatment of clinical disorders of parathyroid function. The extensive section on clinical disorders includes: complete information on the molecular basis, clinical presentation, clinical course, and medical and surgical management of primary hyperparathyroidism; new methods for analyzing bone turnover in primary hyperparathyroidism; detailed discussions on familial forms of hypercalcemia, the parathyroids in renal disease, and hypoparathyroid states; an important chapter on parathyroid hormone as a potential therapy for osteoporosis.
目次
- Embryology, anatomy, pathology
- calcium homeostasis
- regulation of parathyroid hormone by dietary calcium and vitamin D
- interactions of parathyroid hormone with growth factors for bone
- cellular actions of PTH on osteoblast and osteoclast differentiation
- autocrine and paracrine functions of parathyroid tissue
- parathyroid hormone secretory protein
- parathyroid hormone and cyclic AMP, the early days
- regulation of PTH biosynthesis and metabolism: genetic structure and control
- structure/function analysis of parathyroid hormone and PTHRP
- measurement of PTH in the circulation: clinical applications
- non-target actions: parathyroid hormone and PTHRP as polyhormones
- interact of PTH & PTH fragments with conventional & non-conventional receptor sites
- receptors for PTH/PTHRP and other caliotropic hormones
- G proteins as transducers of PTH action
- biochemical mechanisms of PTH action
- the biology of PTHRP: gene, structure, physiologically active forms
- PTHRP as a cause of hypercalcemia
- the skeletal and renal actions of PTHRP
- assays for the actions of PTHRP: measurement of PTHRP in the circulation
- other causes of hypercalcemia
- local and ectopic secretion syndromes
- management of PTH and PTHRP-dependent hypercalcemia
- parathyroid growth-normal and abnormal
- molecular basis of Primary Hyperparathyroidism
- the spectrum of parathyroid tumours in hyperparathyroidism
- clinical presentation of Primary Hyperparathyroidism
- clinical course of Primary Hyperparathyroidism
- newer markets of bone turnover in Primary Hyperparathyroidism
- histomorphometric analysis of bone in Primary hyperparathyroidism
- stone diseases in Primary Hyperparathyroidism
- medical management of Primary Hyperparathyroidism
- surgical management of Primary Hyperparathyroidism
- preoperative localization of parathyroid tissue in primary hyperparathyroidism
- control issues in management of hyperparathyroidism
- parathyroid carcinoma
- acute primary hyperparathyroidism
- multiple endocrine Neoplasia I and other familial forms of hypercalcemia
- multiple endocrine Neoplasia II
- familial hypocalciuric hypercalcemia
- the parathyroids in renal disease
- pathophysiology
- the parathyroids in renal disease
- management
- PTH in abnormalities of Vitamin D metabolism
- hypoparathyroid states in the differential diagnosis of hypocalcemia
- autoimmune aspects of hypoparathyroidism
- the molecuclar basis of hypoparathyroidism
- pseudohypoparathyroid-ism: clinical
- biochemical and molecular features
- rationale for and therapy of hypoparathyroidism
- parathyroid hormone function and responsiveness in osteoporosis
- parathyroid hormone as a potential therapy in osteoporosis
- parathyroid function in Paget's disease
- parathyroid function in magnesium deficiency.
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