The Oncogene handbook
著者
書誌事項
The Oncogene handbook
Academic Press, c1994
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
In recent years there has been an audible clamour for a comprehensive digest of the vast and exciting literature on the molecular biology of cancer. The Oncogene Handbook fulfills this need, providing a definitive guide to the facts about the genes involved in cancer. This compendium summarizes the clinical association and molecular properties of all known oncogenes and tumour suppressor genes, providing instant access to information on any particular facet of the gene of protein. Data covering gene structure and location, mRNA size and the half-life mass, cellular and tissue location, protein structure and function, sequence, databank file name and accession number is clearly and logically presented. This vital reference work will provide the understanding that will fuel further progress in this field, and will be an invaluable resource for research workers and clinicians as well as senior undergraduates and pre-clinical students with an interest in carcinogenesis.
Robin Hesketh is a member if the Department of Biochemistry, University of Cambridge, where his principal research interest is in the control of eukaryotic cell growth. He was previously a staff member of the National Institute for Medical Research, London and has also worked in North America, Australia and at the European Molecular Biology Laboratory at Heidelberg.
目次
Introduction: Tumor Viruses and the Identificiation of Oncogenes. Normal Cell Growth and the Functions of Oncoproteins. General Consequences of Oncogene Expression. Gene Therapy for Cancer. Major Categories of Oncogenes: Oncogenes Transduced By Retroviruses. Oncogenes Activated By Retroviral Insertion. Oncogenes Activated By Retroviral Insertion (Summaries/References). Oncogenes at Chromosomal Translocations. Tumor Suppressor Genes Detected in Human Tumors. Functions of Oncoproteins. Functions of Oncogenes (Summaries). Chromosome Locations of Human Proto-Oncogenes. Sequence Homology with the Protein Kinase Family. Individual Oncogenes.
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