Methods to assess DNA damage and repair : interspecies comparisons

著者

書誌事項

Methods to assess DNA damage and repair : interspecies comparisons

edited by Robert G. Tardiff, Paul H. M. Lohman, Gerald N. Wogan ; prepared by Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC)

（SCOPE, 52）（SGOMSEC, 8）

J. Wiley, c1994

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この図書・雑誌をさがす

注記

"IPCS joint activity ; 19"

Includes bibliographical references and index

内容説明・目次

内容説明

This volume is concerned with a subject basic to chemical risk assessment: DNA damage and repair, taking account of interspecies differences. It evaluates current knowledge of the mechanisms of the activation and detoxication of DNA damaging agents, organotropic and cell-structure effects, induction and repair of DNA damage, and the molecular and phenotypical analysis of mutation induction. The report includes general recommendations aimed at improving research in this field and developing methodologies for genotoxicity testing, taking account of the potentials and limitations of available animal models.

目次

  • JOINT REPORT: Introduction, General Conclusions and Recommendations
  • DNA Damage
  • CONTRIBUTED CHAPTERS: DNA Adducts and their Consequences
  • Nucleotide Excision-Repair Among Species
  • DNA Repair in Specific Sequences and Genomic Regions
  • Molecular Analysis of Mutations in Shuttle Vectors and Transgenic Animals.

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関連文献： 2件中  1-2を表示

  • SGOMSEC

    Wiley

  • SCOPE

    Published on behalf of the Scientific Committee on Problems of the Environment of the International Council of Scientific Unions by Wiley

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