Trophic regulation of the basal ganglia : focus on dopamine neurons
著者
書誌事項
Trophic regulation of the basal ganglia : focus on dopamine neurons
（Wenner-Gren international series, v. 62）
, 1994
1st ed
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注記
Based on a 1992 Wenner-Gren Center symposium
Includes bibliographical references and indexes
内容説明・目次
内容説明
Since 1940 brain and pituitary extracts have been known to be capable of stimulating the proliferation of cultured fibroblasts. In 1974, one of these substances was partially purified and named FGF; later it was realised there exists a family of fibroblast growth factors, of which the best characterised are the FGF-I and FGF-2 (aFGF, BFGF). More recent work has shown that FGFs have many actions and that they are active not only on fibroblasts, but also on a wide range of cell types including those of the central nervous system. This volume represents the state-of-the-art of our understanding of aFGF and bFGF in the basal ganglia. Thus, the localization of those growth factors, the control mechanisms of their expression, and their trophic actions are analyzed in relation to nerve cell survival as well as to the neurodegenerative diseases affecting, the basal ganglia. Some of the most advanced research on degenerative and regenerative features of the basal ganglia is also presented. These studies involve the actions of neurotrophins, epidermal growth factors, gangliosides and neuropeptides as well as their localization and expression in the basal ganglia.
These discoveries should help towards understanding the interactions between trophic factors and transmitters in the control of nerve cell function and their phenotypic maintenance, the studies in this work aim to provide the appropriate background knowledge necessary to fully appreciate the impact of present FGF research on the trophic regulation of the basal ganglia.
目次
Transmitter and Trophic Signals in the Basal Ganglia. Fibroblast growth factor-2, ganglioside GM I and the trophic regulation of the basal ganglia. Focus on the nigrostriatal dopamine neurons (K. Fuxe et al.). Development and Aging of the DA Neurons. Muscle-derived differentiation factor and its regulation of the tyrosine hydroxylase gene in the developing, adult and lesioned rat brain (L. lacovitti,). Oxidative stress and reduced receptor responsiveness in senescence (J.A. Joseph, G.S. Roth) . Growth Factors and Modulators Associated with DA Neurons. Expression. regulation and receptor distribution of neurotrophins in the mammalian central nervous system. (H. Persson et al.). Localization of neurotrophins and their receptors at the mRNA and protein level (L. Olson et al.). Effects of brain-derived neurotrophic factor on injured dopaminergic neurons (F. Hefti et al.). The Role of Astroglia Cells in Trophic Control of DA Neurons. Trophic regulation of the basal ganglia: focus on dopamine neurons (J.P. Schwartz et al.). Neuron-glia interactions: receptor induced events in single astroglial cells and their implications for neuronal excitability and for neurotransmission (E. Hansson et al.). De- and Regenerative Responses in Models of Parkinson's Disease, Huntington's Chorea and Alzheimer's Disease. Neurochemical and behavioural studies on L-DOPA toxicity in the model of manganese lesioned nigrostriatal pathway in the rat: evidence for a protective effect of the GMi lactone siagoside (G. Biagini et al.). De- and Regenerative Responses after Lesions of the DA Neurons. Compensatory neurobiological changes after partial lesions with 6-hydroxy-dopamine (M.J. Zigmond). Trophic Regulations of DA Neurons via Transplants. Clearance and diffusion of locally applied dopamine in normal and 6-hydroxy-dopamine-lesioned rat striatum (B.J. Hoffer et al.). Clinical Aspects and Future Treatments for Parkinson's Disease. The pharmacotherapy of Parkinson's Disease: current status and future (T.N. Chase, M.M. Mouradian). Conclusion. Signal transduction mechanisms on striatal dopaminergic neurons: importance in neurotrophysm and neuropathology (E. Costa).
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