Research designs and methods in psychiatry
Author(s)
Bibliographic Information
Research designs and methods in psychiatry
（Techniques in the behavioral and neural sciences, v. 9）
Elsevier, 1992
- :hard
- :pbk
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
This important contribution to psychiatric literature, coming from a group of investigators who have developed a successful clinical research unit over the last decade, has the immediacy, clarity, and practicality expected from those who have personally wrestled with the difficult issues of design and data analysis. In addition, it draws upon a number of pioneers who have devised methods now used broadly in treatment research in psychiatry. This amalgam presents a very informative, down to earth and readable methods book, that should become the standard text in this growing field of investigation. The volume is divided into four sections: general issues, epidemiology, clinical studies, and psychopharmacology. The material offered in the book serves both as a review for clinical researchers and as a guide to clinicians to facilitate exploration in the fields of psychopathology and treatment. The path from clinical empiricism to scientific process ultimately leads to increased professional gratification and enhanced patient care.
Table of Contents
Foreword by Joseph T. Coyle. Introduction. List of contributors. Part I: General issues. 1. An introduction to concepts in clinical trials. (M. Zelen). 2. Reliability, validity and the effects of misclassification in psychiatric research (D. Blacker). 3. The role of randomization (M. Pagano, C. Spino). 4. Research assessments: to standardize or not to standardize (J.B.W. Williams). 5. A practical guide to the use of survival analysis in research (J.D. Singer, J.B. Willett). 6. The potential impact of meta-analysis on medical care (T.C. Chalmers). Part II: Epidemiology. 7. Methods in genetic epidemiology (S.V. Faraone, S.L. Santangelo). 8. Bias and other methodological issues in follow-up (cohort) studies (M. Tohen). 9. Measurement and design in a longitudinal epidemiologic study: depression and anxiety in a general population (J.M. Murphy). 10. Screening for psychiatric disorder in medical populations (L.R. Derogatis, L. DellaPietra, V. Kilroy). Part III. Clinical studies. 11. Intensive design: statistics and the single case (J.B. Chassan). 12. Estimating rates of change in clinical studies (N.M. Laird). 13. Determining clinical outcome (D.C Beidel). 14. The development of sensitive scales for research in therapeutics (R. Kellner). 15. Measurement of prodromal and subclinical symptoms in mood and anxiety disorders (G.A. Fava). Part IV: Psychopharmacology. 16. Twenty-five years of recurring methods questions in a clinical psychopharmacology laboratory (J.S. Harmatz). 17. Statistical methods for clinical psychopharmacology trials (M.W. Otto). 18. Statistical methods for longitudinal data (C. Waternaux). 19. The role of rating scales in drug trials in depressive disorders (W.W.K. Zung). 20. How to write a study protocol: a primer for the clinician (M. Fava, J.F. Rosenbaum). 21. How to obtain funding: potential sources of support at the National Institute of Mental Health (C.T. Kaelber). Subject index.
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