Current neurochemical and pharmacological aspects of biogenic amines : their function, oxidative deamination, and inhibition

書誌事項

Current neurochemical and pharmacological aspects of biogenic amines : their function, oxidative deamination, and inhibition

edited by Peter M. Yu, Alan A. Boulton, and Keith F. Tipton

(Progress in brain research, v. 106)

Elsevier, 1995

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This book contains anonymous-peer-reviewed invited contributions from the 6th Amine Oxidase Workshop and the 5th Trace Amine Conference. New developments in both basic and applied studies related to monoamine oxidases (MAO), semicarbazide-sensitive amine oxidase (SSAO) and the trace amines are addressed.

目次

  • The colourful past and bright future of monoamine oxidase research
  • radical thoughts about the life of MAO
  • redox properties of flavin cofactor of monoamine oxidases A and B and their relationship to the kinetic mechanism
  • stereochemistry and cofactor identity status of semicarbazide-sensitive amine oxidases
  • expression of human monoamine oxidase (MAO) A gene controlled by transcription factor Sp1.
  • the promoter of the human monoamine oxidase A gene
  • analysis of MAO-A mutations in humans
  • the correlation between platelet MAO activity and personality: short review of findings and a discussion on possible mechanism
  • platelet MAO activities and MAO-B protein concentrations in Parkinson's disease and controls
  • aromatic L-amino acid decarboxylase modulation and Parkinson's disease
  • some new mechanism underlying the actions of (-)-deprenyl: possible relevance to neurogeneration
  • neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamine: new MAO-B inhibitors without amphetamine-like properties
  • enentioselective recognition of two anticonvulsants, FCE 26743 and FCE 28073, by MAO, and relationship between MAO-B inhibition and FCE 26743 concentrations in rat brain
  • Selectivity of MDL-72,974A for MAO-B inhibition based on substrate and metabolite concentrations in plasma
  • the distribution of orally administered (-)-deprenyl-propenyl-14C and (-)deprenyl-phenyl-3H in rat brain
  • novel sites of action for deprenyl in MPTP-Parkinsonism: metabolite mediated protection against striatal neurotoxicity and suppression of MPTP-induced increase of dopamine turnover in C5BL mice
  • effects of transient global ischemia and a monoamine oxidase inhibitor ifenprodil on rat brain monoamine metabolism
  • effects of MAO inhibitor phenelzine on glutamine and GABA concentrations in rat brain
  • metabolism of agmatine (clonidine-displacing substance) by diamine oxidase and the possible implications for studies of imidazoline receptors
  • increase of survival of dopaminergic neuroblastoma in co-cultures with C-6 glioma by R(-)-deprenyl
  • canine pituitary-dependent hyperadrenocorticism: a spontaneous animal model for neurodegenerative disorders and their treatment with l-deprenyl
  • canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to l-deprenyl therapy
  • dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, oxidation and neurotoxicity
  • monoamines, cytoskeletal elements and psychiatric disorders, a neurochemical fugue. (Part contents).

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