Advanced biomaterials in biomedical engineering and drug delivery systems

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書誌事項

Advanced biomaterials in biomedical engineering and drug delivery systems

N. Ogata ... [et al.] (eds.)

Springer, c1996

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Includes bibliographies and indexes

Papers from the 5th Iketani Conference on Biomedical Polymers, held at the Inamori Hall of Kagoshima University from April 18-22, 1995, which focused on advanced biomaterials in biomedical engineering and drug delivery systems and was in honor of Professor Teiji Tsuruta's 75th birthday

内容説明・目次

内容説明

First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time* as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster *session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

目次

  • Advanced Biomaterials.- Controlled Release Systems Using Swellable Random and Block Copolymers and Terpolymers.- Polymer Gel-A New Type of Soft Energy Transducer.- Communicating with the Building Blocks of Life Using Advanced Macromolecular Transducers.- Water-Soluble Nucleic Acid Analogs-Preparation and Properties.- Intelligent Materials.- Functional Synthetic and Semisynthetic Polymers in Biomedical Applications.- Bioconjugates from Synthetic Polymers-How They Can Be Married?.- Plasma Modification of Polymeric Surfaces for Biomedical Applications.- New Polymeric Materials Design for Biomedical Applications.- Novel Approaches to Drug Delivery Systems and Future Trends.- New Oral Drug Delivery System.- Penetration of Polymeric Drug Carriers into K562 Cells.- Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery.- Enhanced Intestinal Absorption of Peptides by Complexation of the Partially Denatured Peptide.- Controlled Drug Delivery Formulation with Safe Polymers.- Supramolecular Assemblies for Improved Drug Delivery System.- Biodegradable Polyphosphazenes for Biomedical Applications.- Receptor-Mediated Cell Specific Delivery of Drugs to the Liver and Kidney.- Biorecognizable Biomedical Polymers.- Nanoscopic Vehicles with Core-Shell Structure for Drug Targeting.- Third Phase in Polymer Drug Development-How They Can Be Married?.- Plasma Modification of Polymeric Surfaces for Biomedical Applications.- New Polymeric Materials Design for Biomedical Applications.- Novel Approaches to Drug Delivery Systems and Future Trends.- New Oral Drug Delivery System.- Penetration of Polymeric Drug Carriers into K562 Cells.- Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery.- Enhanced Intestinal Absorption of Peptides by Complexation of the Partially Denatured Peptide.- Controlled Drug Delivery Formulation with Safe Polymers.- Supramolecular Assemblies for Improved Drug Delivery System.- Biodegradable Polyphosphazenes for Biomedical Applications.- Receptor-Mediated Cell Specific Delivery of Drugs to the Liver and Kidney.- Biorecognizable Biomedical Polymers.- Nanoscopic Vehicles with Core-Shell Structure for Drug Targeting.- Third Phase in Polymer Drug Development-SMANCS As a Prototype Model Drug for Cancer Treatment.- Development of a Tetracycline Delivery System for the Treatment of Periodontal Disease Using a Semisolid Poly(ortho ester).- Mechanistic Aspects of Transdermal Drug Transport.- Transbuccal Delivery of Polar Compounds.- Receptor-Mediated Targeting of Peptides and Proteins.- Temperature Sensitive Polymers for Delivery of Macromolecular Drugs.- Biomedical Engineering.- Novel Biomaterials As Artifical Cornea via Plasma Induced Grafted Polymerization.- Ultrathin Polymeric Films As Biomedical Interfaces of Controlled Chemical Architecture.- Randomness and Biospecificity: Random Copolymers Are Endowed with Biospecific Properties.- Strategy and Bionic Design of Vital Functioning Vascular Wall Reconstruction.- Surface Modification of Biomaterials by Topographic and Chemical Patterning.- Interleukin-4 Mediated Foreign Body Giant Cell Formation and Cytoskeletal Rearrangement on Poly(etherurethane urea) In Vivo and In Vitro.- Polymer-Supported Tissue Engineering.- New Frontier of Biomimetic Glycotechnology for Cellular and Tissue Engineering.- Control of Healing with Photopolymerizable Biodegradable Hydrogels.- A Novel Biomaterial: Aramid-Silicone Resin.- Gradient Surfaces As Tools to Study Biocompatibility.- Preparation of Self-Assembled Biomimetic Membranes and Their Functions.- Synthesis and Cell-Adhesion Properties of Polyurethanes Containing Covalently Grafted RGD-Peptides.- Biomaterials and Biomedical Engineering.- One Pot Synthesis of Poly(ethylene oxide) with a Cyano Group at One End and a Hydroxyl Group at the Other End.- Creation of New Si-Containing Block Copolymer Membrane with Both High Gas Permeability and Blood Compatibility.- Surface Modification of Poly(lactic acid) with Bioactive Peptides.- Adsorption of Biomolecules onto Multiblock Copolymer Consisting of Aromatic Polyamide and Poly(dimethylsiloxane).- Hemocompatible Cellulose Dialysis Membrane Modified with Phospholipid Polymer.- Artificial Glycoconjugate Polymers: Cell-Specific Biomedical Materials Using Carbohydrates As Recognition Signals.- Preparation of Acrylamide Coated PVC Tube by APG Treatment and Its Characterization.- Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer.- Histological and Morphological Comparison of Explanted Small Diameter PU and ePTFE Vascular Prostheses: A Preliminary Study.- Poly(acrylamides) Containing Sugar Residues: Synthesis, Characterization and Cell Compatibility Studies.- Molecular Design of Artificial Lectin
  • Recognition and Killer Cell Induction of Lymphocytes by a Novel Water Soluble Polymer Having Phenylboronic Acid Moiety.- Selective Adhesion and Spontaneous Fusion of Platelets on Polyion Complex Composed of Phospholipid Polymers.- Thermo-Responsive Polymer Surfaces for Cell Culture: Analysis of the Surfaces and Control of the Cell Attachment/Detachment.- RGDS-Carrying Latex Particles for Cell Activation and Integrin Separation.- Estimation of the Secondary Structure of Fibronectin Adsorbed to Polystyrene and Deprotected Poly(?-N-benzyloxycarbonyl-L-lysine) by FTIR ATR Spectroscopy.- Hybrid Biomaterials Comprising Double-Helical DNA. Covalent Coupling Between ? Phage DNA and Poly(N-isopropylacrylamide).- Preparation of Glucose-Sensitive Hydrogels by Entrapment or Copolymerization of Concanavalin A in a Glucosyloxyethyl Methacrylate Hydrogel.- Complexation of Neocarzinostatin Chromophore with a Hydrophobized Polysaccharide As an Apoprotein Model.- Hydrolytic Degradation of Poly(L-lactide-co-?-caprolactone)s.- Selective Adsorption of Plasma Protein onto Phase-Separated Domain of Immobilized Organosilane Monolayer Surfaces.- The Possibility of the Constitution of an Artificial Thymus by Utilizing Keratinocytes.- Improved Nonthrombogenicity of Heparin Immobilized and Sulfonated Polyurethane: In Vitro Evaluation Using Epifluorescent Video Microscopy.- Evaluation of a Newly Developed Biological Patch.- Application of HEMA-St Block Copolymer Coated Small Caliber Vascular Graft for Veins.- Transfer and Surface Fixation of Gels by an Excimer Laser Ablation.- PVA Hydrogel As an Artificial Vitreous Body.- Analysis of Plasma Membrane Glycocalyx and/or of Quantitative Computerized Cytological Image of Platelets Adhered to HEMA-St ABA Type Block Copolymer Surfaces with Good Antithrombogenicity.- Immobilization of Human Thrombomodulin onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer.- Surface Characterization of HEMA-Styrene Block Copolymer Using Transmission Electron Microscopy.- Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups.- Immobilization of Biosignal Proteins to Control Cellular Functions.- Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells.- Cell Cultures on Plasma-Modified Nylon Meshes and Collagen/Nylon Composite Biomatrix.- Direct Extraction of Taste Receptor Proteins by Liposome from Intact Epithelium of Bullfrog Tongue.- The Influence of Serum on the Spreading of Tumor Cells on Synthetic Glycolipid Films.- Transfer of Membrane Proteins from Human Erythrocytes to Liposomes.- Reconstitution of Bovine Placental Insulin Receptor on Artificial Vesicles by Using Direct Protein Transfer Techniques.- Protein Reconstitution from Cell Membrane to Monolayer Using Direct Transfer Technique.- Glucose Responsive Inter-Polymer Complex Gel Based on the Complexation Between Boronic Acid and Polyols-How They Can Be Married?.- Plasma Modification of Polymeric Surfaces for Biomedical Applications.- New Polymeric Materials Design for Biomedical Applications.- Novel Approaches to Drug Delivery Systems and Future Trends.- New Oral Drug Delivery System.- Penetration of Polymeric Drug Carriers into K562 Cells.- Novel Bioadhesive, pH- and Temperature-Sensitive Graft Copolymers for Prolonged Mucosal Drug Delivery.- Enhanced Intestinal Absorption of Peptides by Complexation of the Partially Denatured Peptide.- Controlled Drug Delivery Formulation with Safe Polymers.- Supramolecular Assemblies for Improved Drug Delivery System.- Biodegradable Polyphosphazenes for Biomedical Applications.- Receptor-Mediated Cell Specific Delivery of Drugs to the Liver and Kidney.- Biorecognizable Biomedical Polymers.- Nanoscopic Vehicles with Core-Shell Structure for Drug Targeting.- Third Phase in Polymer Drug Development-SMANCS As a Prototype Model Drug for Cancer Treatment.- Development of a Tetracycline Delivery System for the Treatment of Periodontal Disease Using a Semisolid Poly(ortho ester).- Mechanistic Aspects of Transdermal Drug Transport.- Transbuccal Delivery of Polar Compounds.- Receptor-Mediated Targeting of Peptides and Proteins.- Temperature Sensitive Polymers for Delivery of Macromolecular Drugs.- Biomedical Engineering.- Novel Biomaterials As Artifical Cornea via Plasma Induced Grafted Polymerization.- Ultrathin Polymeric Films As Biomedical Interfaces of Controlled Chemical Architecture.- Randomness and Biospecificity: Random Copolymers Are Endowed with Biospecific Properties.- Strategy and Bionic Design of Vital Functioning Vascular Wall Reconstruction.- Surface Modification of Biomaterials by Topographic and Chemical Patterning.- Interleukin-4 Mediated Foreign Body Giant Cell Formation and Cytoskeletal Rearrangement on Poly(etherurethane urea) In Vivo and In Vitro.- Polymer-Supported Tissue Engineering.- New Frontier of Biomimetic Glycotechnology for Cellular and Tissue Engineering.- Control of Healing with Photopolymerizable Biodegradable Hydrogels.- A Novel Biomaterial: Aramid-Silicone Resin.- Gradient Surfaces As Tools to Study Biocompatibility.- Preparation of Self-Assembled Biomimetic Membranes and Their Functions.- Synthesis and Cell-Adhesion Properties of Polyurethanes Containing Covalently Grafted RGD-Peptides.- Biomaterials and Biomedical Engineering.- One Pot Synthesis of Poly(ethylene oxide) with a Cyano Group at One End and a Hydroxyl Group at the Other End.- Creation of New Si-Containing Block Copolymer Membrane with Both High Gas Permeability and Blood Compatibility.- Surface Modification of Poly(lactic acid) with Bioactive Peptides.- Adsorption of Biomolecules onto Multiblock Copolymer Consisting of Aromatic Polyamide and Poly(dimethylsiloxane).- Hemocompatible Cellulose Dialysis Membrane Modified with Phospholipid Polymer.- Artificial Glycoconjugate Polymers: Cell-Specific Biomedical Materials Using Carbohydrates As Recognition Signals.- Preparation of Acrylamide Coated PVC Tube by APG Treatment and Its Characterization.- Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer.- Histological and Morphological Comparison of Explanted Small Diameter PU and ePTFE Vascular Prostheses: A Preliminary Study.- Poly(acrylamides) Containing Sugar Residues: Synthesis, Characterization and Cell Compatibility Studies.- Molecular Design of Artificial Lectin
  • Recognition and Killer Cell Induction of Lymphocytes by a Novel Water Soluble Polymer Having Phenylboronic Acid Moiety.- Selective Adhesion and Spontaneous Fusion of Platelets on Polyion Complex Composed of Phospholipid Polymers.- Thermo-Responsive Polymer Surfaces for Cell Culture: Analysis of the Surfaces and Control of the Cell Attachment/Detachment.- RGDS-Carrying Latex Particles for Cell Activation and Integrin Separation.- Estimation of the Secondary Structure of Fibronectin Adsorbed to Polystyrene and Deprotected Poly(?-N-benzyloxycarbonyl-L-lysine) by FTIR ATR Spectroscopy.- Hybrid Biomaterials Comprising Double-Helical DNA. Covalent Coupling Between ? Phage DNA and Poly(N-isopropylacrylamide).- Preparation of Glucose-Sensitive Hydrogels by Entrapment or Copolymerization of Concanavalin A in a Glucosyloxyethyl Methacrylate Hydrogel.- Complexation of Neocarzinostatin Chromophore with a Hydrophobized Polysaccharide As an Apoprotein Model.- Hydrolytic Degradation of Poly(L-lactide-co-?-caprolactone)s.- Selective Adsorption of Plasma Protein onto Phase-Separated Domain of Immobilized Organosilane Monolayer Surfaces.- The Possibility of the Constitution of an Artificial Thymus by Utilizing Keratinocytes.- Improved Nonthrombogenicity of Heparin Immobilized and Sulfonated Polyurethane: In Vitro Evaluation Using Epifluorescent Video Microscopy.- Evaluation of a Newly Developed Biological Patch.- Application of HEMA-St Block Copolymer Coated Small Caliber Vascular Graft for Veins.- Transfer and Surface Fixation of Gels by an Excimer Laser Ablation.- PVA Hydrogel As an Artificial Vitreous Body.- Analysis of Plasma Membrane Glycocalyx and/or of Quantitative Computerized Cytological Image of Platelets Adhered to HEMA-St ABA Type Block Copolymer Surfaces with Good Antithrombogenicity.- Immobilization of Human Thrombomodulin onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer.- Surface Characterization of HEMA-Styrene Block Copolymer Using Transmission Electron Microscopy.- Induction of Endothelial Cell Differentiation on Copolymer Surfaces Having Phenylboronic Acid Groups.- Immobilization of Biosignal Proteins to Control Cellular Functions.- Temperature-Modulated Surface Hydrophilic/Hydrophobic Alterations for Novel Recovery of Cultured Cells.- Cell Cultures on Plasma-Modified Nylon Meshes and Collagen/Nylon Composite Biomatrix.- Direct Extraction of Taste Receptor Proteins by Liposome from Intact Epithelium of Bullfrog Tongue.- The Influence of Serum on the Spreading of Tumor Cells on Synthetic Glycolipid Films.- Transfer of Membrane Proteins from Human Erythrocytes to Liposomes.- Reconstitution of Bovine Placental Insulin Receptor on Artificial Vesicles by Using Direct Protein Transfer Techniques.- Protein Reconstitution from Cell Membrane to Monolayer Using Direct Transfer Technique.- Glucose Responsive Inter-Polymer Complex Gel Based on the Complexation Between Boronic Acid and Polyols-Mechanism of Gelation and Glucose Exchange.- Synthesis of Ionic Polyurethane Elastomers As Chemomechanical Materials.- A Synthetic Polyanion Polymer As a Growth Promoter for L929 Mouse Fibroblast.- Adhesion of Fibroblast onto Poly(?-benzyl L-glutamate)/Poly(ethylene oxide) Diblock Copolymer Langmuir-Blodgett Films.- New Bioactive Macromolecular Glycolipids from Bacterial Cell Surface.- 13C-Labeling in Methionine Methyl Groups of Glycophorin AM and Its Effect on the Secondary Structure.- Stabilization of Enzyme by Polymer with Pendant Monosaccharide.- Molecular Architecture of Temperature-Responsive Bioconjugates.- Stabilization of L-Asparaginase by Chemical Modification with Polyethylene glycol) Derivatives.- New Polymeric Hydrogels for the Removal of Uraemic Toxins.- Estimation of Biocompatibility of Polymeric Materials Using RT-PCR Method.- Temperature Responsive Swelling-Deswelling Kinetics of Poly(N-isopropylacrylamide) Grafted Hydrogels.- Temperature-Sensitive Changes in Surface Properties of a Poly(N-isopropylacrylamide) Hydrogel Layer.- Effect of Anion-Exchange Capacity and Porosity of Polyethyleneimine-Immobilized Cellulose Fibers on Selective Removal of Endotoxin.- Cellular Communication with Conducting Electroactive Polymers.- Drug Delivery Systems.- Stimuli-Sensitive Release of Lysozyme from Hydrogel Containing Phosphate Groups.- Slow Release of Heparin from a Hydrogel Made from Polyamine Chains Grafted to a Temperature-Sensitive Polymer Backbone.- Formation of Core-Shell Type Nano-Associates Through Electrostatic Interaction Between Peptide and Block Copolymer with Polyethylene glycol) Segment.- PEG-Poly(lysine) Block Copolymer As a Novel Type of Synthetic Gene Vector with Supramolecular Structure.- Development of Polymeric Micelles for Drug Delivery of Indomethacin.- Synthesis of Heterobifunctional Polyethylene glycol) with a Reducing Monosaccharide Residue at One End for Drug Delivery.- Functional Polymeric Micelles: Synthesis and Characterization.- Micelle Forming Polymeric Anticancer Drug Containing Chemically Bound and Physically Incorporated Adriamycin.- Pharmaceutical Aspects of Block Copolymer Micelles.- Nanosize Hydrogel Formed by Self-Assembly of Hydrophobized Polysaccharides.- Novel Design of Supramolecular-Structured Biodegradable Polymer for Drug Delivery.- Interaction of Poly(ethylene oxide)-Bearing Lipid Reconstituted Liposomes with Murine B16 Melanoma Cells.- Physical Stabilization of Insulin Through Chemical Modification: Site-Specific Glycosylation or PEGylation.- Therapeutic Effects of the Soybean Trypsin Inhibitor and Its Gelatin Conjugate on the Pseudomonal Elastase Induced Shock in Guinea Pig.- The Pulsatile Release System of Macromolecular Drugs from Alginate Gel Beads.- Albumin Release from Bioerodible Hydrogels Based on Semi-Interpenetrating Polymer Networks Composed of Poly(?-caprolactone) and Poly (Ethylene glycol) Macromer.- A Novel Drug Delivery System of Hepatocyte Growth Factor (HGF): Utilization of Heparin-HGF Complex.- New Polymeric Hydrogel Formulations for the Controlled Release of Proteic Drugs: DSC Investigation of Water Structure.- Degradation Mechanism of Azo-Containing Polyurethanes by the Action of Intestinal Flora.- Novel Immunoliposomes Modified with Amphipathic Polyethyleneglycols Conjugated at Their Distal Terminals to Monoclonal Antibodies.- Photo-Induced Drug Release from Liposome Using Photochromic Lipid Having Spiropyran Group.- New Structurally Modified Cyclodextrins for Controlled Release of Antihypertensive Drugs.- Development of Delivery Systems for Antisense Oligonucleotides.- Transfection to Smooth Muscle Cells Using Terplex of LDL, DNA, and Hydrophobized Cationic Polymers.- Preparation of Ammonio-Terminated Polyoxyethylene/Polydimethylsiloxane Block Copolymer and Application to Transdermal Penetration Enhancer.- Theoretical Design of Skin Penetration Enhancement via Prodrug-Enhancer Combination Based on a Diffusion Model.- Preparation of Biodegradable Microspheres Containing Water-Soluble Drug, ?-Lactam Antibiotic.- Effect of Micropore Structure on Drug Release Form Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent.- Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH.- Drug Releasing Mechanism from Redox Active Micelles.- Author Index.- Key Word Index.

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