Molecular toxicology
著者
書誌事項
Molecular toxicology
Oxford University Press, 1997
大学図書館所蔵 全18件
注記
Includes bibliographica references and index
内容説明・目次
内容説明
This book presents the biochemical and molecular biological fundamentals underlying toxicology and drug metabolism. It covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosames, polycyclic aromatic hydrocarbons, and chlorinated compounds.
目次
- Introduction
- 1. Biochemical Background
- 2. Molecular biology and its applications in toxicology
- 3. Biological oxidations
- 4. Superoxide and superoxide dismutase
- 5. Hydrogen peroxide and catalase
- 6. The respiratory burst
- 7. Lipid Peroxidation
- 8. Oxidative stress in the erythrocyte
- 9. Introduction to xenobiotic metabolism
- 10. Clucuronide formation
- 11. Glutathione and detoxication
- 12. Arylamine N-Acetyltransferase
- 13. Sulfotransferase
- 14. Cytochrom P-450
- 15. The AH receptor and the toxicity of chlorinated aromatic compounds
- 16. Identification of DNA adducts
- 17. Chemical mutagenesis
- 18. Carcinogenesis: the genetic targets
- 19. Polycyclic aromatic hydrocarbon carcinogenesis
- 20. Aromatic amines and other N-aryl compounds
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