Antioxidants in disease mechanisms and therapy
著者
書誌事項
Antioxidants in disease mechanisms and therapy
（Advances in pharmacology / edited by Silvio Garattini [and] Parkhurst A. Shore, vol. 38）
Academic Press, c1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.
目次
Natural Antioxidants:
B. Halliwell, Antioxidants: The Basics--What They are and How to Evaluate Them.
A.M. Bode, Metabolism of Vitamin C in Health and Disease.
M.G. Traber, Regulation of Human Plasma Vitamin E.
M.E. Anderson, Glutathione and Glutathione Delivery Compounds.
L. Packer, S. Roy, and C.K. Sen, a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription.
R.J. Reiter, Antioxidant Actions and Melatonin.
E. Lovaas, Antioxidative and Metal Chelating Effects of Polyamines.
L.G. Korkina and I.B. Afanas'ev, Antioxidant and Chelating Properties of Flavonoids.
Synthetic Antioxidants and Enzyme Mimics:
J.-B. Galey, Potential Use of Iron Chelators Against Oxidative Damage.
I.A. Cotgreave, N-Acetylcysteine: Pharmacological Considerations, Experimental and Clinical Applications.
H. Sies and H. Masumoto, Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite.
S.R. Doctrow, K. Huffman, C.B. Marcus, W. Musleh, A. Bruce, M. Baudry, and B. Malfroy, Salen Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy.
Antioxidant Enzyme Induction and Pathophysiology: A.C. Allison, Antioxidant Drug Targeting.
T. Primiano, T.R. Sutter, and T.W. Kensier, Antioxidant-Inducible Genes.
G. Powis, J.R. Gasdaska, and A. Baker, Redox Signaling and the Control of Cell Growth and Death.
R.A. Floyd, Protective Action of Nitrone Based Free Radical Traps Against Oxidative Damage to the Central Nervous System.
J.B. de Haan, E.J. Wolvetang, F. Cristiano, R. Iannello, C. Bladier, M.J. Kelner, and I. Kola, Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome.
P.G. Winyard and D.R. Blake, Antioxidants Redox-Regulated Transciption Factor and Inflammation.
Disease Processes:
H. Esterbauer, R. Schmidt, and M. Hayn, Relationships between Oxidation of LDL, Antioxidant Protection and Atherosclerosis.
S. Louie, B. Halliwell, and C.E. Cross, Adult Respiratory Distress Syndrome: A Radical Perspective.
A. van der Vliet, J.P. Eiserich, G.P. Marelich, B. Halliwell, and C.E. Cross, Oxidative Stress in Cystic Fibrosis: Does It Occur and Does It Matter?
A. Taylor and T. Nowell, Oxidative Stress and Antioxidant Function in Relation To Risk for Cataract.
J.T. Landrum, R.A. Bone, and M.D. Kilburn, The Macular Pigment: A Possible Role in Protection from Age-Related Macular Degeneration.
D.P.R. Muller, Neurological Disease.
W. Droege, A. Grob, V. Hack, R. Kinscherf, M. Schykowski, M. Bockstette, S. Mihm, and D. Galter, Role of Cysteine and Glutathione in HIV Infection and Cancer Cachexia-Therapeutic Intervention with N-Acetyl-Cysteine.
C.S. Lieber, Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Disease.
B. Heller, V. Burkart, E. Lampeter, and H. Kolb, Antioxidant Therapy for the Prevention of Type I Diabetes.
K. Scharfetter-Kochanek, Photoaging of the Connective Tissue of the Skin, Its Prevention and Therapy.
S. Taylor, Antioxidant Nutrients and Cancer Incidence and Mortality: An Epidemiologic Perspective.
Chapter References.
Subject Index.
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