Weir's handbook of experimental immunology
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書誌事項
Weir's handbook of experimental immunology
Blackwell Science, c1996
5th ed
- : set
- タイトル別名
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Handbook of experimental immunology
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注記
Rev. ed. of: Handbook of experimental immunology / edited by D.M. Weir. 4th ed. 1986
内容説明・目次
内容説明
The new fifth edition of the highly acclaimed Handbook of Experimental
目次
- Volume 1: Immunochemistry and Molecular Immunology: The relationship between method and concept
- Placing limits on autoantibody formation: an Immunoregulatory Microcosm
- Section 1: Ig and Variable Region Genes:
- Overview: Genetic Tools for the study of Immunoglobulin Genes and their Function
- Human Immunoglobulin Variable Region Genes
- The sequence analysis Workshop for Windows (SAW): A Desktop computer program enabling a rapid analysis of immunoglobulin super family variable domain sequences
- Kabat Database of Sequences of Proteins of Immunological Interest
- LIGM-DB: An integrated database of IG and TCR, Part of the Immunogenetics Database (IMGT)
- Molecular Evolution of Immunoglobin VH segments
- The Igh-V and Igk-V genes of the mouse
- The murine and human lamda light chain immunoglobulin loci: Organization and Expression
- Immunoglobulin variable region genes of rabbit
- Antibody-Antigen Binding: Structure-Function relationships viewed at atomic scale resolution
- Construction of cDNA from Single Unsimulated B Lymphocytes: Methods and Application to the study of expressed antibody repertoires in FACS-sorted B cell subsets
- The generation of Junctional Diversity of V(D)J recombination
- Section 2: Immunoglobin Rearrangement and Switching:
- Overview: Immunoglobulin Gene rearrangement and Switching
- V(D)J recombination
- Immunoglobulin Variable Region Repertoire Development
- Organization and Mechanism of Rearrangement of Immunoglobulin Genes in Lower Vertebrates
- Immunoglobulin Heavy Chain Class-Switching
- Membrane Immunoglobulin Receptor Complexes
- Signal Transduction by the B Cell Antigen Receptor Complex
- Section 3: Immunoglobulin Isotypes and Allotypes
- Overview: Immunoglobulin Isotypes and Allotypes
- Rat Immunoglobulins Chicken Immunoglobulin Isotypes and Allotypes
- Human Immunoglobulin Isotypes and Allotypes
- Rabbit Immunoglobulin Allotypes
- Mouse Immunoglobulin Allotypes
- Section 4: T Cell Receptor Rearrangements and Variable Region Genes:
- Overview: T Cell Receptor Genetics and Specificity
- TCR Usage in Healthy and Diseased Individuals
- Isolation and Molecular Characterization of Single Antigen-Specific TH Cells
- Establishment of B Cell Hybridomas Producing Antibody Specific for T Cell Antigen Receptor Complex
- Identifying the TCR Ligands of CD8+ and CD4+ T-Cells
- The affinity and kineticsof T-Cell receptor binding to peptide/MHC complexes and the analysis of transient Biomolecular Interactions
- Approaches to a T-Cell specificity
- Section 5: Human and mouse MHC
- Overview: Human and Mouse MHC
- Genomic Organization of the MHC
- MHC and disease associations
- Section 6: Antibody interactions with soluble and solid-phase antigens
- Overview: Antibody affinity: Measurement and biological significance
- Surface immunochemistry
- Antibody reactions with Multiepitopic antigens
- The kinetics of antibody reactions in the fluid phase
- Section 7: Classical Methods:
- Overview: Classical methods
- Haptens and Carriers
- Quantification of Antibodies
- Quantification of Antigens
- Volume 2: Cell Surface and Messenger Molecules of the Immune System:
- Section 8: Flow Cytometry and FACS:
- Overview: Flow Cytometry
- Flow Cytometry Instrumentation and Measurements
- Flourescent Reagents for Flow Cytometric analysis
- FACS analysis of Leukocytes
- Collection, display and analysis of Flow Cytometry data
- Parallel cell sorting complementing FACS
- Purification and analysis of very rare cells
- Assessment of cell physiology by Flow Cytometry
- Glutathione Measurement on the Flow Cytometer
- Apoptosis and the immune system: Flow cytometry techniques for measurement of Apoptosis
- Section 9: Statistics:
- Tour guide of statistical analysis
- Section 10:
- Monoclonal Antibodies to Mouse and Human cluster of Differentiation (CD antigens)
- Overview: Mammalian cell surface antigens
- Isolation of cell surface receptor cDNAs by Expression Cloning
- Quantitative competitive PCR
- Mutational analysis of Lymphocyte Cell surface proteins
- Monoclonal antibodies to human, mouse and rat cluster of differentiation (CD) antigens
- CD45: A family of leukocyte specific cell surface glycoproteins
- FACS analysis of Murine B cell populations
- The CD28 and CD40 receptors contral lymphocyte activation during T cell interactions with B cells
- Natural killer cells and NK cell gene complex
- Hematopoeitic cells
- Section 11: Mammalian Cell Adhesion Receptors and Interaction Molecules:
- Overview: Cell Adhesion Receptors in the Immune System
- Integrin Activation in Lymphocyte Adhesion
- Methods for in vitro Analysis of Leukocyte Adhesion under Flow Conditions
- In vitro Assays of Leukocyte Endotheial Adhesion
- Assays of Selection Function and Specificity
- Chemokine-Induced Lymphocyte Migration: Analysis by Filter-based Bioassays
- Section 12: Cytokine and Cytokine Receptors:
- Overview: Cytokine receptors and signal transduction
- Section 13: Complement and Complement Receptors:
- Overview: Complement and Complement Receptors
- Purification, Assay and Characterization of Complement Proteins from Plasma
- Complement Receptors and Membrane Regulatory Proteins
- Complement Genetics
- Analysis of in vitro Complement Activation
- Production and Analysis of Complement Proteins Using Recombinant Techniques
- Volume 3: The Lymphoid System: Section 14: B-Cell Development:
- Overview: B-Cell development
- Growth and differentiation factors that regulate B Lymphocyte development
- Murine B Cell differentiation in Fetal liver and adult marrow bone
- Self Antigen-Mediated selection in mouse B-Cell development
- Mouse mutants with alterations of genes expressed in the Haematopoietic System
- The early B lymphocyte differentiatiom pathway in humans
- Section 15: Antibody Responses and Affinity Maturation:
- Overview: Antibody responses and affinity maturation
- Use of Adjuvants for enhancement of antibody responses
- Molecular mechanisms of signal transduction by B-Cell receptors
- Methods of polyclonal B lymphocyte activation to proliferation and Ig Secretion in vitro
- Accessory cells in antibody responses
- Lymphocyte dynamics and the application of specific mRNA detection in situ
- Cellular pathways to antibody formation and immunologic memory
- Human peripheral B Cell Subsets
- Control points and affinity maturation in antibody formation
- Section 16: Autoimmunity:
- Overview: Autoimmunity
- Animal models of autoimmunity
- Identification of autoantibodies and the antigens they bind
- Identification of autoantigens recognized by T-Cells
- Transgenic and knockout mice in the analysis of autoimmune disease
- Manipulation of Autoimmune Diseases
- Section 17: Natural Antibodies and Networks:
- Overview: Natural Antibodies and Networks
- The technical and experimental approaches of anti-idiotype antibodies as vaccines
- The design of biologically active small molecular forms derived from functional antireceptor antibodies
- Multiparametric analysis of antibody repetoires
- Antibodies as probes for Epitobe Mapping
- Section 18: Suppression, Cytoxicity and Anergy
- Overview T Cell development in the Thymus
- T Cell development and TCR signalling
- Selective immunosuppression by Class II MHC-binding peptides
- Signal Transduction changes in T Cell from patients with cancer
- Antigen-specific supressor T Cells Generated by Oral Tolerance surpress autoimmune diseases by secretion of TGF-B and TH2 Cytokines
- Epitope-specific regulation of antibody responses
- Analysis of Cytolytic lymphocyte functions
- Section 19: Help Hypersensitivity and Anergy
- Overview: Helper T Cells
- CD4 T Cells and the development of immediate hypersensitivity
- T Cell Anergy
- Section 20: Antigen Presentation:
- Overview: Antigen Processing and presentation of T Cells
- Denditric Cells from human and mouse systems
- Antigen processing and presentation to T Cells
- Eosinophils as antigen presenting cells
- Human monocytes as macrophages antigen presenting cells
- B Cell as antigen presenting cells for T Cells
- Section 21: Apoptosis:
- Overview: Methods in apoptosis
- Morphological features of apoptosis
- Analysis of chromatin Cleavage in apoptotic cells
- The isolation and characterization of cell death genes
- Analysis of apoptotic events using a cell-free system based on Xenopus Laevis eggs
- Methods of measuring BCL-2 gene expression
- Section 22: Classical techniques for autoimmunity:
- Overview: Classical techniques for autoimmunity
- Methods for analysis of autoimmune mice and tolerance loss
- Autoantibodies, idiotypes and immunoglobin genes: Assays and significance
- Viruses and autoimmunity
- Molecular analysis in immunopathology
- Lymphocytes, cytokines and surface markers
- Chemical-induced autoimmunity
- Section 23: Classical techniques for cellular immunology
- Overview
- Contact and delay hypersensitivity
- Adoptive transfer
- Analysis of allograft responses in vivo and in vitro
- Cytotoxic T lymphocytes
- Analysis of in vivo cell migration using flourescent probes
- Lymphocyte migration in vivo assessed with radioisotopes
- Cellular immunity in cattle
- Volume 4: The Integrated Immune System: Section 24: Transgenic, Knockout and gene targeted mice
- Overview: Second generation transgenics
- Recently developed techniques for manipulating the mouse germline and analysing mutant phenotypes
- Overview: Immunologically humanized transgenic mice
- In vitro differentiation of embryonal stem cells as a tool for the study of hematopoieses
- Gene therapy in the lympho-haematopoietic system
- Section 25: Congenic and recombinant inbred mice:
- Overview: Inbred, Congenic and Recombinant Strains
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