Inhalation delivery of therapeutic peptides and proteins

著者

• Adjei, Akete Lex
• Gupta, Pramod K.

書誌事項

Inhalation delivery of therapeutic peptides and proteins

edited by Akwete Lex Adjei, Pramod K. Gupta

（Lung biology in health and disease, v. 107）

M. Dekker, c1997

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This exhaustive reference-the first book of its kind to describe in detail the functionality of the human respiratory tract and its impact on both local and systemic delivery of biotherapeutic and macromolecular drug systems-offers comprehensive analyses of peptide and protein drug delivery through the lung. Summarizes over 130 patents granted worldwide on alternative systems for pulmonary delivery of therapeutic drugs-especially peptides and proteins! Examining macromolecular drug delivery as an efficient, patient-friendly, and cost-effective method of treatment, Inhalation Delivery of Therapeutic Peptides and Proteins discusses airway physiology and biomechanics the pharmaceutical concerns associated with the respiratory tract as a viable port of drug entry to the body key peptide drugs under development and in use to treat local lung disease, including cyclosporines, interferons, antitrypsins, protease inhibitors, and deoxyribonucleases the systemic delivery of peptide and protein drugs using fine-particle technology gene therapy employing gene delivery through the airways new developments in pulmonary delivery technologies emphasizing inhaled peptide and protein drugs guidelines for the successful introduction of peptide inhalation aerosol products into the marketplace and much more!

目次

The Human Respiratory Tract: Biophysical Issues in Peptide Drug Delivery, Pramod K. Gupta Physiological and Biomechanical Factors Relevant to Inhaled Drug Delivery, Chong S. Kim and Lawrence J. Folinsbee Biophysics of Inhaled Drug Particles, Ananth Annapragada, Paul Swanson, and Fernando Muzzio Chemical and Physical Properties of Peptide and Protein Drugs, William R. Porter Absorption and Bioavailability of Inhaled Peptides and Proteins, Yihong Qiu, Pramod K. Gupta, and Akwete Lex Adjei The Human Respiratory Tract: Pharmaceutical Issues in Peptide Drug Delivery, Akwete Lex Adjei Intranasal Delivery of Peptides and Proteins, Lisbeth Illum and Anthony Neil Fisher Therapeutic Inhalation Aerosols, Pramod K. Gupta and Akwete Lex Adjei Generation and Characterization of Aerosols for Drug Delivery to the Lungs, Cecily B. Lalor and Anthony J. Hickey Localized Delivery of Peptides and Proteins to the Lung: Case Studies, Akwete Lex Adjei Cyclosporine, Gilbert J. Burckart, Robert Keenan, Bartley P. Griffith, and Aldo T. Iacono Inhalational Interferon, Nico van Zandwijk Alpha-1 Antitrypsin, Richard C. Hubbard Aerosol Delivery of Alpha1 Proteinase Inhibitor: A Paradigm for Delivery of Therapeutic Proteins to the Lung, Robert M. Smith Deoxyribonuclease Inhalation, Igor Gonda Systemic Delivery of Peptides and Proteins by Inhalation: Case Studies, Akwete Lex Adjei and Pramod K. Gupta Insulin Inhalation: Its Potential as a Nonparenteral Method of Administration, Stephen J. Farr and Glyn Taylor LH-RH Analongs, Akwete Lex Adjei and Mou-ying Fu Lu Feasibility Studies with Recombinant Human Granulocyte Colony-Stimulating Factor, Ralph W. Niven Inhalation Therapy for Growth Hormone Deficiency, Doris A. Wall and Philip L. Smith Gene Delivery and Transfer via the Lung, Akwete Lex Adjei General Issues in Gene Delivery via the Lung, Marsha M. Thompson and Jeanine P. Wiener-Kronish Inhalation Delivery and Formulation Issues in Gene Therapy in the Respiratory Tract, Thomas W. Patapoff and Igor Gonda Gene Therapy for Lung Disease: Molecular and Clinical Therapeutic Issues, Larry G. Johnson and Richard C. Boucher The Cell Biology of Gene Therapy for Cystic Fibrosis, Kenneth Crook and David J. Porteous Alternate Technologies in Pulmonary Delivery, Akwete Lex Adjei and Pramod K. Gupta Non-Ozone-Depleting Propellants, Pramod K. Gupta and Akwete Lex Adjei Dry Powder Inhalation Aerosols, Akwete Lex Adjei and Pramod K. Gupta Modulated-Release Aerosol, Pramod K. Gupta and Akwete Lex Adjei Novel Aerosol Peptide Drug Delivery Systems, Reid Rubsamen Guidelines for Development of Aerosolized Peptides, Akwete Lex Adjei Developmental Pharmaceutics of Inhaled Peptides and Proteins, Akwete Lex Adjei and Pramod K. Gupta Clinical Development of Inhaled Peptides and Proteins, Akwete Lex Adjei Key Worldwide Patents on Pulmonary Drug Delivery, Pramod K. Gupta Key Worldwide Patents in Pulmonary Drug Delivery, Pramod K. Gupta and Akwete Lex Adjei

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詳細情報

• NII書誌ID(NCID): BA31639555
• ISBN:
  • 0824797809
• LCCN: 97015722
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: xxxii, 913 p.
• 大きさ: 24 cm
• 分類:
  • LCC : RS431.P75
  • NLM : W1 LU62 v.107 1997
  • NLM : WB 342 I545 1997
  • DC21 : 615/.6
• 件名:
  • LCSH : Protein drugs -- Dosage forms
  • LCSH : Peptide drugs -- Dosage forms
  • LCSH : Aerosol therapy
  • MESH : Administration, Inhalation
  • MESH : Drug Delivery Systems
  • MESH : Aerosols
  • MESH : Peptides -- therapeutic use
  • MESH : Proteins -- therapeutic use
• 親書誌ID:
  • BA00563007