Carbohydrates in drug design
著者
書誌事項
Carbohydrates in drug design
M. Dekker, c1997
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注記
Includes index
内容説明・目次
内容説明
Emphasizes the role of carbohydrates as anti-inflammatory, anticancer, antidiabetic, anticonvulsant, antibiotic and antiviral agents. The text covers chemical properties, biological functions, methodologies for synthesizing model compounds, conformational and steric effects, synthetic and enzymatic approaches, and the discovery and development of leads in emerging fields.
目次
- Carbohydrates as new and old targets for future drug design
- sialic acid analogues as potential antimicrobial agents
- sialoside mimetics and conjugates as anti-inflammatory agents and inhibitors of flu virus infections
- design and synthesis of cell adhesion carbohydrate ligands/inhibitors
- polysulfates - chemistry and potential as antiviral drugs
- carbohydrates with anticoagulant and antithrombotic properties
- heparin oligosaccharides - new analogues development and applications
- chemoenzymatic synthesis of optically active myo-inositol polyphosphate
- phosphatidylinositol-specific phospholipase C as target of rational drug design
- carba-sugars as indispensable units of aminocyclitol antibiotics and related biologically active compounds
- asazugars - chemistry and their biological activity as potential anti-HIV drugs
- sugar-modified pyrimidine nucleoside analogues with potential antiviral activity
- carbohydrate templates for the synthesis of 3'-hetero-nucleosides
- sugar-modified anthracyclines - a search for drugs able to overcome multidrug resistance
- lincomycin - an organic chemistry perspective
- fungal (1-3)-D-glucans - chemistry and antitumor activity.
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