書誌事項

Serotoninergic neurons and 5-HT receptors in the CNS

editors, H.G. Baumgarten and M. Gothert ; contributors, G.K. Aghajanian ... [et al.]

(Handbook of experimental pharmacology, v. 129)

Springer, c1997

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume provides an comprehensive overview of the anatomy, physiology and basic and applied pharmacology of CNS serotonin neurons and serotonin receptor subtypes required for understanding of the role(s) of serotonin in brain function and in behaviour. The book comprises 28 chapters on various aspects of CNS serotonin neurons, such as their development, plasticity and transduction mechanisms, their structural and functional components involved in synaptic transmission, their physiological properties and their role in behaviour, their putative involvement in neuropsychiatric diseases, and their role as target of drugs used in the treatment of CNS disorders.

目次

- Development and Adult Plasticity of Serotoninergic Neurons and Their Target Cells - Anatomy of Central Serotoninergic Projection Systems - Physiology and Pharmacology of Brain S.N. - Tryptophan Hydroxylase: Molecular Biology and Regulation - Molecular Analysis of Serotonin Packaging into Secretory Vesicles - Regulation of the Environment of the Interior of Serotonin-Storing Vesicles - Molecular Biology and Transductional Characteristics of 5-HT Receptors - 5-Hydrotryptamine Receptor Histochemistry: Comparison of Receptor mRNA Distribution and Radioligand Autoradiography in the Brain - The Main Features of Central 5-HT1A Receptors - Functional Neuropharmacology of Compounds Acting at 5-HT 1B/D Receptors - 5-HT-Moduline, an Endogenous Peptide Modulating Serotoninergic Activity via a Direct Interaction of 5-HT 1B/1D Receptors - Regulation of 5-HT Release in the CNS by Presynaptic 5-HT Autoreceptors and by 5-HT Heteroreceptors - Behavioral Consequences of 5-HT1B Receptors Gene Deletion - Pharmacology of 5-HT2 Receptors - Regulation of 5-HT2A Receptor at the Molecular Level

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