CiNii Books - Principles of medical pharmacology

This is the Sixth Edition of a teaching text that has undergone continuous evolution and improvement since 1975. It has been extensively revised, enlarged and updated to reflect the latest research. The authors have "pre-tested" it in their own courses to ensure accessibility and clarity of presentation. Though aimed primarily at medical students, the text has also found wide acceptance in pharmacology courses for students in biological sciences, pharmacy and dentistry, and among practicing pharmacists and physicians. The text covers all aspects of medical pharmacology, including a comprehensive discussion of the clinically important features of pharmacokinetics. It also provides a detailed treatment of topics that are often given less attention in similar texts, such as drug abuse and dependence, behavioral pharmacology, drug interactions, neonatal and geriatric pharmacology, and new drug development. This new edition features a number of improvements over its predecessors. Each chapter in the systems pharmacology section now begins with a brief case history that is meant to stimulate the reader's interest by demonstrating the clinical relevance of basic pharmacology. New overview chapters and sections have been added on second messenger systems, and on the functional organization of the nervous, cardiovascular, gastrointestinal, and immune systems. The chapter on antiparasitic agents has been expanded to include organisms and drugs with relevance to many parts of the world. Extensive sections on current chemotherapy of HIV infection and AIDS along with discussions of new agents for drug-resistant tuberculosis, malaria and cancer; inflammatory bowel disease; and genetics of drug metabolism appear for the first time in the Sixth Edition. Due attention has been paid to new drugs being tested in North America and Europe that will probably be on the market soon.

Table of Contents

I. GENERAL PRINCIPLES OF PHARMACOLOGY
1. Introduction to General Pharmacology
2. Drug Solubility, Absorption, and Movement Across Body Membranes
3. Drug Distribution
4. Drug Biotransformation
5. Pharmacokinetics
6. Clearance: The Quantitative Basis of Dosage
7. Drug Clearance by Specific Organs
8. Dose-Response Relationships
9. Drug Receptors
10. Signal Transduction and Second Messengers
11. Selectivity of Drug Action
12. Human Pharmacogenetics
II. AUTONOMIC NERVOUS SYSTEM AND NEUROMUSCULAR JUNCTION
13. Autonomic Nervous System Neurotransmitters
14. Autonomic Cholinergic Agonists
15. Autonomic Cholinergic Antagonists
16. Adrenoceptor Agonists
17. Adrenoceptor Antagonists
18. Drugs Acting on Adrenergic Neurons (Adrenergic Neuronal Blocking Drugs)
19. Neuromuscular Transmission and Drugs (Muscle Relaxants)
III. CENTRAL NERVOUS SYSTEM
20. Functional Organization of the Central Nervous System
21. Agents Modifying Movement Control
22. Antiseizure Drugs
23. Opioid Analgesics and Antagonists
24. General Anesthetics
25. Local Anesthetics
26. The Alcohols
27. Anxiolytics and Hypnotics
28. Antipsychotics
29. Antidepressant and Mood Stabilizing Agents
30. Hallucinogens and Psychotomimetics
IV. MEDIATORS AND MODIFIERS OF TISSUE RESPONSES
31. The Eicosanoids
32. Autacoids
33. Histamine and Antihistamines
34. Anti-Inflammatory Analgesics
V. CARDIOVASCULAR SYSTEM
35. Cardiovascular System Overview and Organization
36. Digitalis Glycosides and Other Positive Inotropic Agents
37. Antiarrhythmic Drugs
38. Vasodilators
39. Hyperlipoproteinemias and Antihyperlipidemic Drugs
VI. RESPIRATORY, RENAL, AND BLOOD SYSTEMS
40. Drugs and the Respiratory System
41. Diuretics
42. Drugs Affecting Hemostasis
43. Drugs Affecting Erythropoiesis
VII. GASTROINTESTINAL SYSTEM
44. Pharmacotherapy of Acid-Peptic Disorders
45. Drugs Used in the Treatment of Intestinal Motility Disorders and Inflammatory Disease
46. Drugs, Alcohol and the Liver
VIII. ENDOCRINE SYSTEMS
47. Vasopressin, Oxytocin, and Uterotonic Drugs
48. Thyroid Hormones and Antihyperthyroid Drugs
49. Gonadotropic and Gonadal Hormones
50. Insulin and Oral Hypoglycemic Drugs
51. Adrenocortical Steroid Hormones
IX. ANTI-INFECTIVE CHEMOTHERAPY
52. Principles of Antimicrobial Therapy
53. Antimicrobial Agents That Act upon Bacterial Cell Wall Formation
54. Antimicrobial and Antifungal Agents That Act upon Cell Membranes
55. Antimicrobial Agents That Affect the Synthesis of Cellular Proteins
56. Drugs Affecting Cellular Nucleic Acid Synthesis
57. Chemotherapy of Common Parasitic Infections
58. Antiviral Agents
59. Antiseptics, Disinfectants, and Sterilization
X. ANTINEOPLASTIC CHEMOTHERAPY, IMMUNOPHARMACOLOGY
60. Antineoplastic Drugs
61. Immune System Organization, Modulation, and Pharmacology
XI. SPECIAL TOPICS OF PHARMACOLOGY
62. Sources of Individual Variation in Drug Response
63. Adverse Drug Reactions
64. Drug Interactions
65. Perinatal Pharmacology
66. Geriatric Clinical Pharmacology
67. Vitamins
68. Drugs Altering Bone Metabolism
69. Chemical Carcinogenesis
70. Chemical Teratogenesis
71. Behavioral Pharmacology
72. Drug Abuse and Drug Dependence
73. Principles of Toxicology
74. Poisonings and Antidotal Therapy
75. Drug Development and Regulations
INDEX

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Principles of medical pharmacology

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