Quinolone antibacterials
著者
書誌事項
Quinolone antibacterials
（Handbook of experimental pharmacology, v. 127）
Springer, 1997
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The quinolones continue to make a significant contribution in the fight against community or hospital-acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of quinolones. A lot of effort has been undertaken to optimize structure-activity relationships with the aim of producing more potent drugs with an optimal therapeutic index.
目次
- History and introduction
- the chemistry of the quinolones - methods of synthesizing the quinolone ring system
- chemistry in the periphery of the quinolones
- mode of action
- the in vitro antibacterial activity of quinolones - a review
- pharmacokinetics of fluoroquinolones in experimental animals
- pharmacodynamics of fluoroquinolones in experimental animals
- interaction of quinolones with host-parasite-relationships
- mechanisms of resistance to fluoro-quinolones
- toxicology and safety pharmacology of quinolones
- clinical pharmacology
- concentration-effect relationship of the fluoroquinolones
- clinical use of quinolones
- future aspects.
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