Statistics in human genetics
著者
書誌事項
Statistics in human genetics
（Arnold applications of statistics series）
Arnold , J. Wiley, 1998
- :: uk
- :: us
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注記
Includes bubliographical references (p. [269]-280) and indexes
内容説明・目次
- 巻冊次
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:: uk ISBN 9780340662410
内容説明
In human genetic research, sophisticated statistical methods are increasingly being used to analyse results. Until now there has been no book to introduce and explain these methods. The methods are based on both biology and statistics and are likely to contribute to major scientific and medical advances in the next century. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis. An understanding of elementary statistical concepts is assumed, but the objectives, principles and limitations of the methods are discussed in detail. The book will interest scientists engaged in human genetic research and advanced students of genetics and statistics.
目次
- Basic population genetics
- components of variance and structural equation models
- linkage analysis
- associate analysis
- statistical issues in genetic probability calculations
- overview.
- 巻冊次
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:: us ISBN 9780471194880
内容説明
This is the first book to introduce and explain the sophisticated statistical methods used in human genetics research. It assumes an understanding of elementary statistical concepts and discusses the objectives, principles and limitations of these methods in detail.Systematic, balanced treatment of the subject.
-- Reference to recent researched in the field.
-- Numerical examples illustrate methods.
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