Oncogenes and tumour suppressors
Author(s)
Bibliographic Information
Oncogenes and tumour suppressors
（Frontiers in molecular biology, 19）
IRL Press at Oxford University Press, c1997
- hbk
- pbk
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Note
Includes bibliographical references and index
Description and Table of Contents
- Volume
-
pbk ISBN 9780199635948
Description
Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present and critically assess our current knowledge. The book covers two major areas of interest: oncogenes and signal transduction, and tumour supressors and cell cycle control. Topics covered
include the mechanisms of oncogene perturbation; growth factors and their receptors in cell transformation; oncogenic cytoplasmic protein tyrosine kinases; the RAS/RAP/ERK signal transduction pathway; oncogenic transcription factors; mammalian cell cycle control; the retinoblastoma gene product and its
relatives; the tumour suppressor gene p53; tumour suppressors and the inheritance of cancer; the clinical relevance of oncogenes. Oncogenes and Tumour Suppressors is a major review work that provides an unparalleled summary of our current understanding of this field as viewed by some of its leading researchers. It is of interest to all those involved in research on the cell cycle, signal transduction, and cancer biology. The book is also an excellent reference source with over 1800 selected
citations to the primary literature.
Table of Contents
- PART I ONCOGENES AND SIGNAL TRANSDUCTION
- 1. Mechanisms of oncogene preturbation
- 2. Growth factors
- 3. Growth factor receptors in cell transformation
- 4. Oncogenic cytoplasmic tyrosine kinases
- 5. The RAS/RAF/ERK signal transduction pathway
- 6. Oncogenic transcription factors: FOS, JUN, MYC, MYB, and ETS
- PART II TUMOUR SUPPRESSORS AND CELL CYCLE CONTROL
- 7. Mammalian cell cycle control
- 8. The retinoblastoma gene product and its relatives
- 9. The tumour suppressor gene p53
- 10. Tumour suppressor genes and inheritance of cancer
- 11. Clinical relavance of oncogenes
- Volume
-
hbk ISBN 9780199635955
Description
Oncogenes and tumour suppressor genes have been the focus of much research because of their role not only in cancer but also in normal cell growth and differentiation. Oncogenes and Tumour Suppressors is a unique volume that brings together a team of leading researchers to present and critically assess our current knowledge. The book covers two major areas of interest: oncogenes and signal transduction, and tumour supressors and cell cycle control. Topics covered include the mechanisms of oncogene perturbation; growth factors and their receptors in cell transformation; oncogenic cytoplasmic protein tyrosine kinases; the RAS/RAP/ERK signal transduction pathway; oncogenic transcription factors; mammalian cell cycle control; the retinoblastoma gene product and its relatives; the tumour suppressor gene p53; tumour suppressors and the inheritance of cancer; the clinical relevance of oncogenes. Oncogenes and Tumour Suppressors is a major review work that provides an unparalleled summary of our current understanding of this field as viewed by some of its leading researchers. It is of interest to all those involved in research on the cell cycle, signal transduction, and cancer biology.
This book is intended for graduates, post-doctoral researchers, and academic staff.
Table of Contents
Part I Oncogenes and Signal Transduction. 1: Mechanisms of oncogene preturbation. 2: Growth factors. 3: Growth factor receptors in cell transformation. 4: Oncogenic cytoplasmic tyrosine kinases. 5: The RAS/RAF/ERK signal transduction pathway. 6: Oncogenic transcription factors: FOS, JUN, MYC, MYB, and ETS. Part II Tumour suppressors and cell cycle control. 7: Mammalian cell cycle control. 8: The retinoblastoma gene product and its relatives. 9: The tumour suppressor gene p53. 10: Tumour suppressor genes and inheritance of cancer. 11: Clinical relavance of oncogenes
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